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Flashcards in PharmII_Exam1_pract Deck (57):
1

What is the drug of choice for gas gangrene?

Penicillin G

2

What do PCNs combine with and inactivate?

Transpeptidase
A PCN binding protein

3

Are PCNs bacteriostatic or bactericidal?

Bacteriocidal

4

What simultaneous administration prolongs duration of PCN?

Probenecid

5

99% of PCN G and V are eliminated via where?

Kidney

6

Which antistaph PCN has poor oral adsorption?

Methicillin

7

What is the drug of choice for Listeria?

Ampicillin

8

Which drug is employed prophylactically by patients with abnormal heart valves, who are to undergo oral surgery?

Amoxicillin

9

Are ampicillin and amoxicillin resistant to penicillinase?

No

10

Which 3 drugs are effective against indole-positive proteus?

Carbenicillin
Ticarcillin
Piperacillin

11

What antipseudomonal drug can cause platelet dysfunction?

Piperacillin

12

Name the most potent ureido-penicillin?

Piperacillin

13

How does penicillin penetrate CSF?

Only with inflammation

14

The highest incidence of hypersensitivity to PCN occurs with which?

Ampicillin

15

Are cephalosporins effective against penicillinase producing bacteria?

Yes.
Due to increase in resistance

16

What class of antimicrobials are drug of choice for Klebsiella?

Cephalosporin

17

What are 1st gen cephalosporins active against?

PEcK
Proteus
E. coli
Klebsiella

18

Name the alternative to anti-staph PCN in penicillin allergic patients?

Cefazolin

19

Name the drug of choice in surgical prophylaxis?

Cefazolin

20

What are 2nd generation cephalosporins active against?

HEN PEcK

21

Name the 1st line of drugs for N. Gonorrheae?

Ceftriaxone - IV
Cefixime-oral

22

Name the cephalosporins that are useful against P. aerugionsa?
What generation

Ceftazidime
Cefoperazone
3rd generation

23

What are Cetizoxime and Moxalactam active against?

Bacteroides fragilis
(3rd gen staph)

24

Name two cephalosporins that are excreted through the biliary tract?

Cefoperazone
Ceftriaxone

25

What cephalosporin group are used to treat meningitis?

3rd generation

26

Which drug is active against MRSA?

Vancomycin

27

Which beta lactam antibiotic has the broadest spectrum and what is it used for?

Imipenem/cilastatin
Used in empiric therapy.

28

How is bacitracin administered?
Why?

Look up

29

What drug is used for corneal ulcers and external otitis?

Polymyxin B

30

What is Polymyxin restricted to treating?

Gram - bacteria.

31

Is polymyxin Bacteriostatic or bacteriocidal?

Bacteriocidal

32

What is cycloserine mainly used for?

TB

33

Which beta lactam is used in umbrella therapy?

Imipenem

34

What is the MOA of beta lactams?

Inhibit cell wall synthesis

35

Which antibiotic is highly active against Treponema pallidum(syphilis)?

PCN

36

Name two beta lactams that are not excreted via the kidney?

Cefoperazone and Ceftriaxone

37

Which drug is it safe to treat UTI in prego chicks?

Fosfomycin
one dose

38

Increased resistance to hydrolysis of chromosomal beta lactamse is specific to what generation cephalosporin?

4th generation

39

Which drug is used in carriers of meningococcal infxns?

Minocycline

40

What is effective against ROcky Mountain Spotted Fever(Ricksettia)?

All tetracyclines
Chloramphenicol

41

Which of the following is the most imp mech of resistance to tetracyclines?

Reduced permeability or increased efflux by an active transport protein pump.

42

What is the tetracycline of choice for SIADH?

Demeciocycline

43

What is the tetracycline of choice in renal insufficiency?

Doxycycline (excreted via bile).

44

A skin rash is a type of what........

Hypersensitivity rxn

45

Which drug is resistant to staphy beta-lactamases?

Oxacillin

46

Which group of drugs are Effective against pseudomonas aeruginosa (gram neg)

Carbenicillin,
Ticarcillin,
Azlocillin,
Piperacillin,
Mezlocillin

47

Which drug is eliminated in the bile?

Nafcillin
(good for renal dysfunction patients)

48

Which is the drug of choice for bacterial meningitis?

Ceftriaxone

49

Does Probenecide help with NAfcillin?

NO!!! Bcaz Nafcillin is eliminated in the bile.

50

Which drug is used for empiric therapy?

Impenem

51

MOA of monobactam?

Inhibits bacterial cell wall synthesis

52

Trt for respiratory tract infections?

Aztreonam
This is the only monobactem

53

Vancomycin is given slowly through IV to treat what condition?

Endocarditis

54

What is the name of the structure on the test?

Cephalospoprin

55

What is used to treat Pseudomonas causing corneal ulcers?

Polymyxin B

56

What is used to treat atypical pneumonia caused by Mycoplasm?

Doxycycline

57

What is an AE of flucytosine?

Reverse bone marrow suppression