PharmII_Exam1_pract

Question 1

What is the drug of choice for gas gangrene?

Answer 1

Penicillin G

Question 2

What do PCNs combine with and inactivate?

Answer 2

Transpeptidase

A PCN binding protein

Question 3

Are PCNs bacteriostatic or bactericidal?

Answer 3

Bacteriocidal

Question 4

What simultaneous administration prolongs duration of PCN?

Answer 4

Probenecid

Question 5

99% of PCN G and V are eliminated via where?

Answer 5

Kidney

Question 6

Which antistaph PCN has poor oral adsorption?

Answer 6

Methicillin

Question 7

What is the drug of choice for Listeria?

Answer 7

Ampicillin

Question 8

Which drug is employed prophylactically by patients with abnormal heart valves, who are to undergo oral surgery?

Answer 8

Amoxicillin

Question 9

Are ampicillin and amoxicillin resistant to penicillinase?

Answer 9

No

Question 10

Which 3 drugs are effective against indole-positive proteus?

Answer 10

Carbenicillin
Ticarcillin
Piperacillin

Question 11

What antipseudomonal drug can cause platelet dysfunction?

Answer 11

Piperacillin

Question 12

Name the most potent ureido-penicillin?

Answer 12

Piperacillin

Question 13

How does penicillin penetrate CSF?

Answer 13

Only with inflammation

Question 14

The highest incidence of hypersensitivity to PCN occurs with which?

Answer 14

Ampicillin

Question 15

Are cephalosporins effective against penicillinase producing bacteria?

Answer 15

Yes.

Due to increase in resistance

Question 16

What class of antimicrobials are drug of choice for Klebsiella?

Answer 16

Cephalosporin

Question 17

What are 1st gen cephalosporins active against?

Answer 17

PEcK
Proteus
E. coli
Klebsiella

Question 18

Name the alternative to anti-staph PCN in penicillin allergic patients?

Answer 18

Cefazolin

Question 19

Name the drug of choice in surgical prophylaxis?

Answer 19

Cefazolin

Question 20

What are 2nd generation cephalosporins active against?

Answer 20

HEN PEcK

Question 21

Name the 1st line of drugs for N. Gonorrheae?

Answer 21

Ceftriaxone - IV

Cefixime-oral

Question 22

Name the cephalosporins that are useful against P. aerugionsa?
What generation

Answer 22

Ceftazidime
Cefoperazone
3rd generation

Question 23

What are Cetizoxime and Moxalactam active against?

Answer 23

Bacteroides fragilis

3rd gen staph

Question 24

Name two cephalosporins that are excreted through the biliary tract?

Answer 24

Cefoperazone

Ceftriaxone

Question 25

What cephalosporin group are used to treat meningitis?

Answer 25

3rd generation

Question 26

Which drug is active against MRSA?

Answer 26

Vancomycin

Question 27

Which beta lactam antibiotic has the broadest spectrum and what is it used for?

Answer 27

Imipenem/cilastatin | Used in empiric therapy.

Question 28

How is bacitracin administered? | Why?

Answer 28

Look up

Question 29

What drug is used for corneal ulcers and external otitis?

Answer 29

Polymyxin B

Question 30

What is Polymyxin restricted to treating?

Answer 30

Gram - bacteria.

Question 31

Is polymyxin Bacteriostatic or bacteriocidal?

Answer 31

Bacteriocidal

Question 32

What is cycloserine mainly used for?

Answer 32

TB

Question 33

Which beta lactam is used in umbrella therapy?

Answer 33

Imipenem

Question 34

What is the MOA of beta lactams?

Answer 34

Inhibit cell wall synthesis

Question 35

Which antibiotic is highly active against Treponema pallidum(syphilis)?

Answer 35

PCN

Question 36

Name two beta lactams that are not excreted via the kidney?

Answer 36

Cefoperazone and Ceftriaxone

Question 37

Which drug is it safe to treat UTI in prego chicks?

Answer 37

Fosfomycin | one dose

Question 38

Increased resistance to hydrolysis of chromosomal beta lactamse is specific to what generation cephalosporin?

Answer 38

4th generation

Question 39

Which drug is used in carriers of meningococcal infxns?

Answer 39

Minocycline

Question 40

What is effective against ROcky Mountain Spotted Fever(Ricksettia)?

Answer 40

All tetracyclines | Chloramphenicol

Question 41

Which of the following is the most imp mech of resistance to tetracyclines?

Answer 41

Reduced permeability or increased efflux by an active transport protein pump.

Question 42

What is the tetracycline of choice for SIADH?

Answer 42

Demeciocycline

Question 43

What is the tetracycline of choice in renal insufficiency?

Answer 43

Doxycycline (excreted via bile).

Question 44

A skin rash is a type of what........

Answer 44

Hypersensitivity rxn

Question 45

Which drug is resistant to staphy beta-lactamases?

Answer 45

Oxacillin

Question 46

Which group of drugs are Effective against pseudomonas aeruginosa (gram neg)

Answer 46

``` Carbenicillin, Ticarcillin, Azlocillin, Piperacillin, Mezlocillin ```

Question 47

Which drug is eliminated in the bile?

Answer 47

Nafcillin | good for renal dysfunction patients

Question 48

Which is the drug of choice for bacterial meningitis?

Answer 48

Ceftriaxone

Question 49

Does Probenecide help with NAfcillin?

Answer 49

NO!!! Bcaz Nafcillin is eliminated in the bile.

Question 50

Which drug is used for empiric therapy?

Answer 50

Impenem

Question 51

MOA of monobactam?

Answer 51

Inhibits bacterial cell wall synthesis

Question 52

Trt for respiratory tract infections?

Answer 52

Aztreonam | This is the only monobactem

Question 53

Vancomycin is given slowly through IV to treat what condition?

Answer 53

Endocarditis

Question 54

What is the name of the structure on the test?

Answer 54

Cephalospoprin

Question 55

What is used to treat Pseudomonas causing corneal ulcers?

Answer 55

Polymyxin B

Question 56

What is used to treat atypical pneumonia caused by Mycoplasm?

Answer 56

Doxycycline

Question 57

What is an AE of flucytosine?

Answer 57

Reverse bone marrow suppression