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Flashcards in PharmII_Final Deck (82):
1

What are the effects of endogenous histamine?

Decrease BP
Increase HTN

2

Which antihisamine generation have more sedating effects?

H1 antagonists 1st generation

3

Which antihistamine in the 2nd generation has the most sedating effects?

Zyrtec

4

Which receptor/mechanism does allergic rhinitis act on?

H1

5

What is the most rapid onset of the 5-HT1B agonist?

Rizatriptan
A newer drug and most effective for migraines

6

Which is a prophylactic drug for migraine headaches?

Beta blockers. Propranolol is effective in reducing frequency and intensity of headaches in 2/3 of patients.

7

What is the first option to treat acute(episodic) tension headaches?

OTC NSAIDs:
ibuprofen
aspirin
Naproxen
acetaminophen(remem this is not an NSAID)

8

Which drug potentiates GABA and has affinity for BZ1 and BZ2 receptors

Alprazolam.
I think any benzodiazepine would work.

9

Which non-benzodiazepine acts at the BZ1 receptor, given for insomnia?

Ambien and Sonata
Lunesta is nonselective

10

Which drug is given to treat only absence seizures?

Ethosuximide

11

Which drug is given for simple partial and myotonic seizures?

Valproate

12

Which is the drug of choice for partial seizures

Phenytoin
Carbamazepine

13

What is the action of Sinemet inhibit?

Peripheral decarboxylase reducing available L-Dopa

14

MAO-B?

Selegiline

15

Which drug cannot be used to treat Chorea?

Selegiline

16

Which drug is CI for Parkinsons?

Haloperidol

17

Name a high potent conventional antipsychotic?

Haloperidol

18

name a low potency antipsychotic?

Chlorpromazine
Thioridazine

19

What can't you use PPI in?

Non-ulcer dyspepsia

20

How long to wait to take PPI

One hour before a meal so it can get to canaliculus

21

Which drug act on mucosal recpetors to drecease acid secretions?

Misoprostol
It is a prostaglandin analog

22

What does misoprostol do to prego chicks?

It causes uterine contractions

23

Which drug has mixed receptor actions (both agonist and antagonist)?

Nubain

24

Which drug is used for treatment of opioid abuse?

BUprenex
Naloxone, Nalmefene, Naltrexone(longest actin)

25

Which is not an effect of an opioid on CNS?

Anti-inflammation

26

Which drug irreversibly binds to COX1?

Aspirin

27

Which drug is given for the prophylactic trt of coronary artery disease that also blocks platelet aggregation?

Aspirin

28

Which drug will cause Fatal Hepatic necrosis and acute renal failure?

Acetaminophen

29

What do you give a patient if they overdose on Acetaminophen?

N-acetylcysteine
-gastric lavage
-replenish glutathione

30

Which drugs were withdrawn due to its prothrombin effects?

Vioxx
Bextra

31

Which NSAID is a high potency propionic acid derivative?

Ketoprofen

32

Which drug increases the elimination of uric acid?

Probenecid/
Also Anturane

33

What condition can't you use SSRI for?

Mania

34

Which drug is precribed to help patients stop smoking?

Bupropion

35

Which drug is used to treat acute mania?

Lithium

36

If you can't use lithium to treat mania, what is another option?

Valproate

37

Which drug is a NRI?

Atomoxetine
Approved for ADHD

38

Which drug causes death at high doses?

Secobarbital

39

Which drug is gien IV for maintenance of general anesthesia along with Bupivicaine?

Fentanyl.
It is 100X more potent than morpine

40

Which drug is given for post-op pain after dental work has been done?

Methadone

41

Name an opioid with hihgh oral bioavailability?

Codeine

42

Midazolam

Short acting BDZ.
Used for anesthesia

43

Which anxiolytic takes about 1 week to take effect?

Buspar

44

T/F?
Phenytoin is not dependent on both
boltage and use dependent?

False!
It is dependent!!!

45

T/F?
Valproate can displace phenytoin from plasma proteins thus increasing its concentration?

True story

46

Which anti-epileptic causes irreversible visual impairment?

Vigabatrin

47

What is the name of the pre-cursor that precedes transport across the BBB?

L-dopa

48

Which Parkinsons drug does not cross the BB?

Carbidopa

49

Which medication is best used along with domperidone to treat the off phase in Parkinsons?

Apomorphine

50

Which drug is contraindicated with patients with cardio problems?

Thioridazine
Ziprasidone
Citalopram

51

If a patient Overdoses on Haloperidol, what do you give them?

Dantrolene and Bromocriptine

52

What is the first line agent for many psychoses?

Risperidone

53

What antidepressant also treats neuropathic pain

Amitriptyline(Nortriptyline)
-Methadone
Gabapentin
Opiods won't do jack

54

Are opioids good for neuropathic pain or nociceptive pain?

Nociceptive pain!!!

55

MOA of nortriptyline?

Post synaptic membrane suppression

56

Prozac + Olanzapine =

Symbyax
Treats bipolar

57

What acts as a Serotonin Norepinephrine Reuptake inhibitor (SNRI) and aids in more potent NE transport

Duloxetine

58

If giving a patient hydrocodone and increase more of it and give more doses and stilll nothing happens, what do you give?

Hydromorphone
U give a stronger agonist

59

What are the four things u never get tolerant to for opioids?

Bradycardia (moderate tolerance)

miosis (diagnostic)
Constipation
Convulsant

60

What is the most likely event of barbiturate overdose?

Respiratory failure

61

What can antagonize the effects of opiod overdose?

Naloxone

62

What can be used to aid in opioid withdrawal?

Methadone

63

Why is naloxone given with opioid drugs?

TO decrease abuse

64

Name the drug that is:
Full agonist at kappa
Antagonist at mew

Nubain

65

Name the drug that is:
full agonist at kappa
partial agonist at mew

Pentazocine

66

Name the drug that is
antagonist at kappa
partial agonist at mew

Buprenex

67

Name the drug that is
STRONG agonist at kappa
Partial agonist at mew

Butorphanol.
Matches with Pentazocine

68

Why does NSAIDs cause duodenal cancers in a patient being treated for ZOllinger Ellison Syndrome?

Bcaz it blocks prostaglandins

69

WHich drugs is not used for gout?

Aspirin and Tolectin

70

Febuxostat MOA?

Decreases Xanthine oxidase which decreases uric acid production

71

Name the topical antihistamine used for ocular pruritus?

Azelatine
Olopatadine

72

Name a COX 2 selective agent?

Celecoxib

73

Name the NSAID that is a potent analgesic used for short term trt of moderately severe acute pain such as post op pain used in place of morphine?

Ketorolac

74

What is the first line agent for chronic tension headaches?

Nortriptyline

75

What is effective before the start of a headache?

Aspirin
Acetaminophen
Caffeine

76

When can you absolutely not use the triptan class?

Vascular disease

77

T/F?
Acetaminophen can be used for the trt of reversible angioedema?

NOPE
U cannot use acetaminophen for edema!

78

Which patients can't you use bupropion in?

Patients with high seizures

79

Name the three MAOIs?
What happens if you mix with a sympahtomimetic?

Phenylzine
Tranycypromine
Moclomide

HTN crisis

80

Moclomide

Specific (MAO-A) and reversible. A newer class described as RIMAs (Reversible
inhibitors of MAO-A).

81

Bipolar disorder ptx takes thiazide duretics and expriences muscle twitching, dizziness, and blured vision.
What is the cause?

Decreased levels of sodium due to lithium accumulation

82

T/F?
It is OK to combine SSRI with MAOI?

FALSE
u will surely die