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Flashcards in Photocarcinogenesis Deck (52)
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1

Bullous impetigo
(blistering at site of infection)

Caused by staphylococcus toxin A

2

Staphylococcal scalded skin syndrome

Caused by staphylococcus toxin B
Most common in children
Low mortality rates

3

Organism usually causing cellulitis

Beta haemolytic strep

4

Another name for basal cell papilloma

Seborrhoeic wart

5

Appear as firm, elevated pigmented nodules which may feel like a button in the skin
They are often found on the legs and commoner in females
There may be a history of trauma or insect bite

Dermatofibroma

6

Keratoacanthoma

Rapidly growing epidermal tumours which develop central necrosis and ulceration
They occur on sun exposed sites and can grow to 2-3cm across
Whilst they may resolve spontaneously, best to surgicaly remove as they can mimic squamous cell carcinoma

7

Where does Bowen's disease most commonly develop?

Lower womens legs

8

Where would you usually develop a pilar cyst?

The scalp

9

Key characteristics or "hallmarks" of cancer

1. Insensitivity to growth signals
2. Insensitivity to anti-growth signals
3. Evade death (apoptosis)
4. Limitless potential to divide
5. Angiogenesis
6. Invasion and metastasis

10

Basal cell carcinoma and exposure

Intermittent exposure

11

Squamous cell carcinoma and exposure

Chronic exposure

12

Melanoma and exposure

Intermittent exposure

13

Lattitude and skin cancer

Incidence increases closer to equator

14

Skin colour and eye colour and cancer

Red/fair haired individuals with blue eyes and freckling

15

Where would patients with Xeroderma pigmentosum (XP) develop skin cancer?

Skin exposed areas

16

UVC wavelength

200-280 nm

17

UVB wavelength

280-315 nm

18

UVA wavelength

315-400 nm

19

Visible light spectrum

400-700 nm

20

UV signature mutation

Cytosine to thymine (at dipyrimidine sites)

21

NER

Nucleotide excision repair

22

BER

Base excision repair

23

DSB

Double strand break repair

24

MMR

Mismatch repair

25

Which UV is mainly responsible for initiating mutations?

UVB

26

Which UVs are responsible for promoting mutations etc

UVB/UVA

27

Estiamted action spectrum for cancer in humans?

298nm

28

Age onset of MM?

<20 years

29

Merkel cell skin cancer exposure

?cumulative

30

HPV associated with which types of skin cancer?

BCC and SCC