Structure and Function 1 Flashcards Preview

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Flashcards in Structure and Function 1 Deck (27):
1

How many GP consultations for skin?

I in 5

2

Which germ layer is the epidermis made from?

Ectoerm cells form single layer periderm
Gradual increase in layers of cells
Periderm cells cast off

3

Which germ layer forms the dermis?

The dermis is formed from the MESODERM (below ectoderm)

4

KGPBD

Keratin layer
Granular layer
Prickle cell layer
Basal layer
Dermis

5

Connective tissue, less cellular

Dermis

6

What is the sub-cutis mainly made from

Fat

7

The epidermis is 95% made from these cells

Keratinocytes

8

Epidermis is made of which type of cells?

Stratified squamous

9

How many layers in epidermis?

4
(KGPB)

10

Other cells found in the epidermis

Melanocytes
Langerhans cells
Merkel cells

11

Where do keratinocytes migrate from and what does this mean for the epidermis

Migrate from the basement membrane
Continous regeneration of epidermis
28 days from bottom to top

12

How many cells thick is the basal layer?

1 cell
Small cuboidal

13

Usually one cell thick
Small cuboidal
Lots of intermediate filaments (keratin)
Highly metabolically active

Basal layer

14

Lots of intermediate filaments in this layer

Basal layer

15

Larger polyhedral cells
Lots of desmosomes (connections)
Intermediate filaments connect to desmosomes

Prickle cell layer

16

2-3 layers of flatter cells
Large keratohyalin granules – contain structural filaggrin & involucrin proteins
Odland bodies (lamellar bodies)
High lipid content
Origin of “cornified envelope”
Cell nuclei lost

Granular layer

17

Which layer are nuclei lost in?

Granular layer

18

Which layer are odland bodies found?

Granular

19

Which layer are lamellar bodies found in?

Granular
(lamellar bodies = odland bodies)

20

Origin of "cornified envelope"

Granular layer

21

Layer with a high lipid content?

Granular layer

22

Where are corneocytes found?

Keratin layer

23

What are corneocytes?

Overlapping non-nucleated cell remnants

24

Where is the insoluble cornified envelope?

Keratin layer

25

What do lamellar granules release?

Release lipid (in the granular layer)

26

Which type of cell does HPV affect?

Keratinocytes

27

Mucosa that is keratinised to deal with friction/pressure

Masticatory