Physiology Flashcards

(58 cards)

1
Q

Location of I cells

A

duodenum, jejunum

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2
Q

I cells secrete

A

CCK in response to FA and AA

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3
Q

Action of CCK

A

increase pancreatic secretion, GB contraction
relaxes sphincter of Oddi
decreases gastric emptying

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4
Q

Location of G cells

A

antrum of stomach

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5
Q

G cells secrete

A

gastrin in response to stomach distention/alkalinization, AA, peptides, vagal stimulation

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6
Q

Action of Gastrin

A

Increase H+, increase gastric mucosa and gastric motility

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7
Q

Zollinger-Ellison Syndrome

A

increases gastrin immensely

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8
Q

2 Amino acids the stimulate gastrin the most

A

Phenylalanine and Tryptophan

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9
Q

Location of K cells

A

Duodenum and Jejunum

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10
Q

K cells secrete

A

Glucose-dependent insulinotropic peptide

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11
Q

Exocrine action of Glucose-dependent insulinotropic peptide

A

decrease H+ in stomach

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12
Q

Endocrine action of Glucose-dependent insulinotropic peptide

A

Increase insulin release

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13
Q

Increase release from FA, AA, and ORAL glucose

A

Glucose-dependent insulinotropic peptide (GIP)

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14
Q

Produces migrating motor complexes

A

Motilin

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15
Q

Motilin receptor agonist

A

Erythomycin

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16
Q

Where motilin is secreted from

A

Small Intestine

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17
Q

Location of S cells

A

Duodenum

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18
Q

Secreted from S cells

A

Secretin

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19
Q

Action of Secretin

A

increase HCO3 from pancreas, decrease gastric acid secretion, increases bile secretion

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20
Q

Cause of Sercetin release

A

Increased acid and FA in lumen of duodenum

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21
Q

Location of D cell

A

Pancreatic Islets and GI mucosa

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22
Q

Secreted from D cells

A

Somatostatin, released in response to increased acid or decreased by vagal stimulation

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23
Q

Inhibits digestion and absorptionof substances needed for growth

A

Somatostatin

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24
Q

Action of Somatostatin

A

decrease H+ and pepsinogen secretion, decrease pancreatic and sm intestine fluid, decrease GB contraction, decreases insulin and glucagon release

25
Copious Watery Diarrhea, Hypokalemia and Achlorhydria
VIPoma
26
Increases intestinal water and electrolyte secretion, increases relaxation of intestinal smooth muscle and sphincters
VIP
27
Loss of this secretion will lead to achalasia (increase LES tone)
Nitric Oxide
28
Parietal cells
Intrinsic factor req vitB12 binding and uptake into ileum | decrease pH
29
Pernicious anemia
autoimmune destruction of parietal cells (B12 deficiency)
30
Gastrinoma
gastrin-secreting tumor that causes high levels of acid secretion and ulcers refractory to medical therapy
31
Chief Cells of Stomach
release pepsinogen made into pepsin
32
Pepsin action
protein digestion
33
Activation of pepsinogen
Pensin and acid (H+)
34
Released from ECL
Histamine Release
35
Activates Parietal Cells
histamine, gastrin, ACh
36
Brunner Glands
Located at duodenal submucosa, secretes alkaline mucus, hypertrophy in peptic ulcer disease
37
Pancreatic secretion - Low Flow
high chloride
38
Pancreatic secretion - High Flow
high HCO3-
39
alpha-amylase
starch digestion
40
lipase, phospholipase A and colipase
fat digestion
41
trypsin, chymotrypsin, elastase, carboxypeptidases
Proteases from Pancreas (secreted as zymogens)
42
Trypsinogen
converted to trypsin by enterokinase/enteropeptidase (positive feedback loop)
43
Carbohydrate Absorption
only monosaccharides are absorbed by enterocytes
44
SGLT1
Sodium dependent glucose and galactose uptake
45
G:UT5
Fructose transportor (facilitated diffusion)
46
GLUT2
all monosaccharides transporter to blood
47
D-xylose absorption test
Distinguishes mucosal damage vs other causes of malabsorption of carbohydrates
48
Area for Iron Absorption
Duodenum
49
Area for Folate absorption
Jejunum and ileum
50
Absorbed in terminal Ileum
B12 along with bile acids
51
Specialized M cells
In Peyers Patches (ileum) and sample and present Ag to immune cells
52
Peyers Patches
IgA secretory
53
Water soluble Bile salts
Those conjugated with glycine or taurine
54
Rate limiting step in bile synthesis
Cholesterol 7alpha-hydroxylase
55
Product of heme metabolism
Bilirubin
56
Removal of bilirubin
conjugated with glucuronate and excreted in bile
57
Direct bilirubin
conjugated with glucuronic acid; water soluble
58
Indirect Bilirubin
Unconjugated; water insoluble