Physiology: Haemoglobin and Gas Transport Flashcards Preview

System 1: Respiratory AM > Physiology: Haemoglobin and Gas Transport > Flashcards

Flashcards in Physiology: Haemoglobin and Gas Transport Deck (38)
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1

What does blood transport from lungs into tissues?

O2

2

What does blood transport as a waste product from tissues to the lungs?

CO2

3

How much O2 can be dissolved in a 1L of plasma?

3ml of oxygen

4

What aids the carrying of oxygen ability in blood?

Haemoglobin in red blood cells

5

How much O2 can be dissolve in blood with RBC containing Haemoglobin?

200ml/ L

6

Is arterial partial pressure of O2 = to arterial concentration/ content of O2?

No

7

Why is arterial partial pressure of O2 not = to arterial concentration/ content of O2?

Partial arterial pressure of O2 only refers to O2 in the plasma solution

8

Why do gases not travel in gaseous phase through blood?

As an air embolism may occur

9

How much much of the arterial O2 extracted by peripheral tissues at rest?

25%

10

What partial pressure of arterial blood equal too?

Oxygen pressure within the plasma solution

11

How much of the oxygen in blood bound to haemoglobin?

98%

12

How many oxygen molecules bind to 1 haemoglobin?

4

13

What is the most prevalent haemoglobin in RBC?

HbA

14

What are the types of haemoglobin in RBC?

HbA
HbF
HbA2
HbA1a
HbA1b
HbA1c

15

What is the fundamental determinant of how saturated haemoglobin is saturated with oxygen?

Partial Pressure of Oxygen in arterial blood

16

What allows oxygen to be extracted from alveoli into arterial blood?

Partial Pressure gradient between the alveoli and pulmonary capillaries

17

What maintains the partial pressure gradient in blood?

Hb taking O2 from the plasma and Hb is saturated

18

When does the haemoglobin saturation fall below 90%?

When PaO2 is under 60mmHg

19

What other forms of haemoglobin have a higher affinity of O2?

Myoglobin
Foetal Haemoglobin (HbF)

20

Why do myoglobin and HbF have a higher affinity for O2 than HbA?

As they need to extract O2 from maternal blood or require high amount of O2 due to high activity

21

Define the condition Anaemia?

Condition where oxygen carrying capacity of blood is compromised

22

What can cause anaemia?

Iron deficiency
Haemorrhage
Vitamin B12 deficiency

23

What Chemical factors affect Haemoglobin Affinity?

pH - more alkaline higher affinity, more acidic less affinity
PCO2 - less CO2 higher affinity for O2
Temp - lower temp higher affinity
DPG - binding fo 2,3-DPG decreases affinity

24

What is 2,3-diphosphoglycerate (2,3-DPG) produced by?

Erythrocytes

25

When does 2,3-DPG increase?

When low O2 supply

26

Why is Carbon Monoxide Toxic?

Haemoglobin has a higher affinity to CO than O2

27

What are the symptoms to carbon monoxide poisoning? (6)

Hypoxia and Anaemia
Nausea and Headaches
Cherry Red Skin
Mucous Membrane
RR not affected due to normal PCO2
Brain Damage and Death

28

What is the definition of Hypoxia?

Inadequate supply of O2 to tissues

29

What are the 5 main Types of Hypoxia?

Hypoxaemic - most common
Anaemic
Stagnant
Histotoxic
Metabolic

30

What is Hypoxaemic Hypoxia?

Reduced O2 diffusion at lungs due to decreased PO2atmos or tissue pathology