PI

Question 1

What type of drug is Methylphenidate

Answer 1

Psychostimulants

Question 2

What is the mechanism of action of Methylphenidate

Answer 2

Increases firing rates of dopaminergic neurones, thus

increase in dopamine.
Methylphenidate inhibits dopamine reuptake transporters,
thus prolongs effect of dopamine in the synaptic cleft.

Question 3

What is Methylphenidate used to treat

Answer 3

ADHD

Question 4

What are the side effects of Methylphenidate

Answer 4

Potential for growth
retardation in children.
BP and HR irregularities
Insomnia, Anorexia.

Question 5

What type of drug is Dexamphetamine

Answer 5

Psychostimulants

Question 6

What is the mechanism of action of Dexamphetamine

Answer 6

Dexamphetamine facilitates the release of dopamine
from the presynaptic cytoplasmic storage vesicles. This
results in a net increase in dopamine levels.

Question 7

What is Dexamphetamine used to treat

Answer 7

ADHD

Question 8

What are the side effects of Dexamphetamine

Answer 8

Potential for growth
retardation in children.
BP and HR irregularities
Insomnia, Anorexia.

Question 9

What class of drug is Atomoxetine

Answer 9

Noradrenaline Reuptake Inhibitor (NRI)

Question 10

What is the mechanism of action of Atomoxetine

Answer 10

2nd line drug in ADHD. Enhances noradrenaline

transmission in the prefrontal cortex area

Question 11

What is Atomoxetine used to treat

Answer 11

ADHD

Question 12

What are the side effects of Atomoxetine

Answer 12

Dizziness, Sedation,

Hypotension

Question 13

What type of drug is Vemurafenib

Answer 13

BRAF Enzyme Inhibitor

Question 14

What is the mechanism of action of Vemurafenib

Answer 14

Vemurafenib is a reversible, ATP-competitive inhibitor of
the kinase domain of BRAF. This drug shrinks tumours in
about half of the people whose metastatic melanoma has a BRAF gene change.

Question 15

What is Vemurafenib used to treat?

Answer 15

Metastatic Tumours, BRAF

mutation.

Question 16

What type of drug is Ipilimumab

Answer 16

Anti-CTLA-4 monoclonal antibody

Question 17

What is the mechanism of action of Ipilimumab

Answer 17

Blocks CTLA-4 antigen on the T cell, which is normally
required as the “off switch” for cytotoxic T cells to prevent
it from activating an immune response.

Question 18

What is Ipilimumab used to treat?

Answer 18

Cancer, Metastasis

Question 19

What are the side effects of Ipilimumab

Answer 19

May result in loss of

peripheral tolerance.

Question 20

What class of drug is Nivolumab

Answer 20

Anti-PDL1

Question 21

What is the mechanism of action of Nivolumab

Answer 21

PD-L1 is expressed on cancer cells. PD1 is expressed on T cells. If they activate, the T cell will

Question 22

What is Nivolumab used to treat

Answer 22

Cancer, Metastasis

Question 23

What type of drug is Fluoxetine

Answer 23

Selective Serotonin
Reuptake Inhibitors
(SSRIs)

Question 24

What is Fluoxetine used to treat

Answer 24

Prevent the reuptake of serotonin at the post-synaptic

membrane.

Question 25

What is the mechanism of action of Fluoxetine

Answer 25

Depression

Question 26

what are the side effects of Fluoxetine

Answer 26

Nausea, vomiting, agitation, sexual dysfunction, hyponatremia, sweating

Question 27

What type of drug is Amitriptyline

Answer 27

Tricyclic Antidepressants (TCAs)

Question 28

What is the mechanism of action of Amitriptyline

Answer 28

Prevent the reuptake of serotonin at the post-synaptic | membrane.

Question 29

What is Amitriptyline used to treat

Answer 29

Depression

Question 30

What type of drug is Phenelzine

Answer 30

Anticholinergic effects, sedation, weight gain, hyponatremia, cardiotoxic effects, hallucinations

Question 31

What is the mechanism of action of Phenelzine

Answer 31

Monoamine Oxidase | Inhibitors (MAOIs)

Question 32

What is Phenelzine used to treat

Answer 32

Irreversible, non-competitive inhibitors of monoamine | oxidases.

Question 33

What are the side effects of Amitriptyline

Answer 33

Depression

Question 34

What type of drug is Imatinib

Answer 34

Tyrosine Kinase Inhibitor

Question 35

What is the mechanism of action of imatinib

Answer 35

Works by inhibiting the abl gene. Thus the mutated bcr- | abl composition is broken.

Question 36

What is imatinib used to treat

Answer 36

Chronic Myeloid Leukaemia

Question 37

What type of drugs are: Donepizil Rivastigmine Galantamine

Answer 37

Cholinesterase Inhibitors

Question 38

What is the mechanism of action of: Donepizil Rivastigmine Galantamine

Answer 38

These increase brain acetylcholine levels by inhibiting CNS acetylcholinesterase. Effective in DLB and Parkinson’s Dementia but not FTD/Vascular dementia Effective in mild/moderate AD

Question 39

What are the following used to treat: Donepizil Rivastigmine Galantamine

Answer 39

Dementia with Lewy Bodies (DLB) & Parkinson’s Dementia | Alzheimer’s Disease (mild/moderate)

Question 40

What class of drug is Memantine

Answer 40

NMDA Receptor Antagonist

Question 41

What is the mechanism of action of Memantine

Answer 41

Memantine blocks the NMDA channel, reducing the chance of a post-synaptic action potential. There is a buildup of glutamate in AD brains, thus Memantine is used to stop the overactivity of the glutaminergic system.

Question 42

What is Memantine used to treat?

Answer 42

Alzheimer’s Disease (moderate/severe)