What is the most common cause of conjunctivitis
Adenovirus
What are the two most common causes of acute viral rhinitis?
Rhinovirus
Coronavirus
What are the different symptoms of a cold and flu
High fever in flu, no flu in cold
Extreme exhaustion in flu, none in cold
Flu happens quickly
Cold is gradual
Why was the causative agent of SARS a surprise to virologists?
It is coronoviris, which has always though to have been benign until then.
-coronovirus with serious attitude
Why is aspirin contraindicated in children
Reye’s syndrome
- rapid liver failure and encephlopathy
- occurs in children given ASA for viral infections
What are the orthomyxoviridae?
Influenza only
ORdinary flu
What are the paramyxoviruses?
PARAde of viruses
- parainfluenza
- mumps
- measles
- respiratory syncytial virus (RSV)
Symptoms of measles
High fever, conjunctivitis
What is influenza type A, B, C
- Flu A=widespread, multiple subtypes, found in many animal (humans pigs birds)
- flu B=less widespread
- Flu C=rare
Which types of flu are mild and found in humans
Flu B and C
What is genetic drift
Small mutations/ minor changes in the virion
What is genetic shifts
Abrupt/major reassortments of segments of animal and human H/N spikes that produce new strains
Facilitates and penetration of virus into host cells
Hemagglutinnin (H)
Assist the virion in entry and budding (escaping) from the cell
Neuraminindase (N)
What is the influenza hemagglutin subtype that poses the greatest threat for human pandemic and death
H5 and H7s
What are the two drugs discussed in class with the appropriate mode of administration
Relenza (inhaled) and tamiflu (PO)
What is the benefit of giving a neuramindase inhibitor within 2 days of a person becoming symptomatic
70-90% effective at diminishing symptoms and ending early as long as it is within 2 days, otherwise you looks the window of opportunity
