Polycystic kidney diease

Question 1

are cysts common

Answer 1

50% of people >50 have them. usually discovered incidentally. occassionally cause pain/haematuria

Question 2

types of polycystic kidney disease

Answer 2

ADPKD (most common)

ARPKD v rare

Question 3

when does ADPKD present

Answer 3

adult life (even though it is inherited)

Question 4

ADPK due to mutation in what gene

Answer 4

PKD1 ( codes for polycysten)

also can be PKD2 or PKD3

Question 5

presentation of ADPKD causes by kidney dysfunction

Answer 5

• acute loin pain
• cyst bleeds -> haematuria
• infected cyst

Question 6

presentation of ADPKD due to associated idseases

Answer 6

• HTN (early and v common feature)
• liver cysts
• SAH due to berry aneurysm
• uraemia/anaemia associated with CKD

Question 7

ix ADPKD

Answer 7

USS
urinalysis
fbc (

Question 8

rx ADPKD

Answer 8

no rx
control BP
treat renal pain
usually require renal replacement therapy (accounts for 10% dialysis pts)

Question 9

ARPKD - what age does it present

Answer 9

used to be called infantile PKD as presents in childhood

Question 10

PKD associated with

Answer 10

cerebral aneurysm
mitral valve prolapse
inguinal hernia
(bc there is a problem with collagen)