Renal cell carcinoma Flashcards
1
Q
most common renal cancer
A
adenomacarcinoma of adrenal cortex arising from PCT
2
Q
most common histological subtype of renal cell carcinoma
A
clear cell RCC (renal cell carcinoma)
3
Q
RFs RCC
A
-genetic smoking, obesity, hypertension -renal fialure -PKD -horseshoe kidney
4
Q
what autosomal dominant disorder is associated with renal cell carcinoma
A
von hippel Lindau
5
Q
ix RCC
A
- urinalysis (rule out UTI)
- USS/CT (most diagnosed incidentally when being imaged for other reasons)
- cyctoscopy (exclude bladder turmours as cause)
- CT chest and abdo for mets
- CXR- lung mets
- biopsy
- FBC (anaemia)
- Ca2+
- LFT
- U&E (often normal bc kidney can still work)
- bone scan if mets suspected
6
Q
classic mets
A
cannonball mets. almost diagnostic. (multiple large well defined masses in both lungs, measuring up to 7 cm)
7
Q
rx RCC
A
nephrectomy
8
Q
classic triad of presentation (rarely seen now)
A
haematuria
loin pain
loin mass
9
Q
other presentations
A
- fatigue, weight loss, varicoele, ankle oedema
- 25-30% with mets
- paraneoplastic symptoms e.g. hypercal, abnormal LFTs, anaemia
10
Q
it is one of the cancers that metastasises to…
A
bone
bridney
11
Q
staging RCC
A
TNM
12
Q
rx RCC
A
(partial) nephrectomy depending on size.
