Practical Exam 2 - AOIs and Muscles Flashcards

Question

Skeletal muscle components

Answer 1

Each muscle is made of individual muscle fibers (muscle cells) organized by fascicles; Epimysium surrounds muscle bundles of fascicles; Perimysium surrounds individual fascicles; Fascicles made of individual muscle fibers; Endomysium surrounds individual muscle fibers

Answer 2

Myofilament Sarcomere (series of myofilaments in a specific pattern) Myofibril (bundle of sarcomeres) Muscle fiber or myocyte (contains multiple myofibrils) Fascicle (bundle of muscle fibers) Skeletal muscle (composed of multiple fascicles)

Answer 3

Strokes damaging neurons in the brain leading to a loss of motor function

Answer 4

An electric charge differential which can be changed upon stimulation (such as through neurotransmitter binding) to ultimately produce an intracellular muscle response; All muscle cell membranes possess this

Answer 5

All muscle cells shorten when stimulated

Answer 6

All muscle cells can be stretched, sometimes more than their resting length

Answer 7

All muscle cells, after being stretched, can recoil to the resting cell length

Answer 8

An entire skeletal muscle (like the gastrocnemius) is an organ that contains nerves, blood vessels, and connective tissue, as well as muscle fibers

Answer 9

Blood vessels enter the muscle near its centre and then branch throughout the muscle running through the connective sheaths (epimysium, perimysium, and endomysium)

Answer 10

Connective tissues that attach muscle to bone; Connective tissue sheaths of muscle are continuous with each other and with tendons to transfer the force of contracting muscle fibers to the structure to be moved; Cylindrical shaped or rope-like

Answer 11

The bone or structure that is moving

Answer 12

The bone or structure that mostly does not move

Answer 13

If periosteum (membrane surrounding bones) or perichondrium (connective tissue surrounding cartilage of developing bone) is fused with the muscles epimysium

Answer 14

More durable, smaller, and more common; A tendon or aponeurosis

Answer 15

Flat, tendon-like connective tissue that connects muscles to other muscles, skin, or bones

Answer 16

Tendons: Mostly collagen; rope-like extensions of a muscles connective tissue Aponeurosis: Sheet-like extension that connects to other muscles

Answer 17

Two or more muscles usually work antagonistically; As one muscle contracts and shortens, its antagonist relaxes and elongates Ex: Curling a dumbbell towards you contracts your biceps as your triceps relax, and bringing your arm away from you contracts your triceps as your biceps relax

Answer 18

Large multinucleated cells; Contains sarcolemma, sarcoplasm, myoglobin, glycosomes

Answer 19

Plasma membrane of a muscle fiber

Answer 20

Cytoplasm of a muscle fiber

Answer 21

Myocyte Myofiber Skeletal muscle cell

Answer 22

Muscle cells contain a lot of myoglobin; Stores oxygen

Answer 23

Muscle cells contain a lot of glycosomes; Granules of glycogen that ca be broken down to supply ATP from glucose for energy

Answer 24

Repeating units of sarcomeres; Takes up most of the intracellular volume; Organelles of skeletal muscles

Answer 25

Smallest "atomic" contractile units of skeletal muscle fibers

Answer 26

Dark A bands and light I bands within sarcomeres that are perfectly lined beside one another

Answer 27

I-band A-band H-band Z-line M-line

Answer 28

Lightest areas of sarcomere; Only made of thin filaments composed of actin

Answer 29

Darkest areas of sarcomere; Composed of myosin and actin

Answer 30

Area within A-band; Composed of only thick filaments made of myosin

Answer 31

Defines boundary of sarcomere and bisects I-band and neighboring sarcomeres; Sarcomere runs from Z-line to Z-line

Answer 32

Center of sarcomere to which myosin bind

Answer 33

Contain protein myosin and run the length of the A band; M-line connects thick filaments; Thick filaments only have myosin heads in areas where actin proteins of the thin filament and the myosin heads of the thick filament overlap; Each thick filament contains over 300 myosin molecules

Answer 34

Myosin proteins contain protruding globular heads and each head associates with two light chains; When a muscle contracts, the globular myosin heads link the thick and thin filaments together making cross bridges and swivel as motors to create force that shortens the sarcomere

Answer 35

Consists of a helix of two actin subunit strands and the proteins tropomyosin and troponin; Each actin subunit is a globular actin and contains active sites where myosin heads attach

Answer 36

Each have a different function 1) Binds actin 2) Binds tropomyosin 3) Calcium ions bind with the last; Sandwiched between the other two troponin polypeptides

Answer 37

Composed of the protein titin; Run from the Z-line to the thick filaments to hold them in place and provide flexible recoil to the sarcomere as it contacts, relaxes, and stretches; When titin reaches its normal extension, it stiffens and resists further over-stretching of the muscle

Answer 38

Smooth endoplasmic reticulum; Interconnects and surrounds each myofibril; Forms terminal cisterns; Highly abundant mitochondria and glycogen granules found near; Controls calcium levels within the sarcoplasm and stores and releases calcium to control muscle fiber contraction

Answer 39

Large perpendicular cross channels formed by the sarcoplasmic reticulum at the A band I band junction; Always found in pairs

Answer 40

Elongated tubular extensions of the sarcolemma dive deeply into the cell; Found at A band I band junctions

Answer 41

T tubule with terminal cisterns on both sides

Answer 42

When a nerve stimulates a muscle, an electrical signal travels down the sarcolemma, and since T tubules are tubular extensions of the sarcolemma, the electrical signal can be carried deep into the muscle to every sarcomere; Electrical signal causes the release of calcium from the terminal cisterns which leads to contraction

Answer 43

Both t tubules and the terminal cisterns have integral membrane proteins that protrude into the space between these structures; Integral proteins of t tubules function as voltage sensors while the integral proteins of the terminal cisterns create gated channels for the release of calcium

Answer 44

Inside of the cell is more negative relative to the outside; All plasma membranes of all human cells carry this and resting charge

Answer 45

Acetylcholine binds to its receptor opening chemical ligand-gated ion channels for sodium; These events transiently make the inner surface of the sarcolemma less negative (depolarization) and is termed the End Plate Potential

Answer 46

Voltage-gated sodium channels on the surrounding sarcolemma respond to the change in charge and open allowing positive sodium to enter down its electrochemical gradient; Once a threshold potential is achieved, the voltage change in the membrane becomes sufficient to open further voltage-gated sodium channels and spread the signal in the form of depolarization wave along the sarcolemma termed a Muscle Action Potential

Answer 47

Once the voltage becomes sufficiently positive, the voltage-gated sodium channels close, and the voltage-gated potassium channels open; The membrane then becomes more negative (repolarizes) as positive potassium exits the cell down its concentration gradient; Once the membrane becomes sufficiently negative again, this change in charge closes the voltage-gated potassium channels

Answer 48

Gradient differences for sodium and potassium are restored by a sodium potassium ATPase pump that moves sodium out and potassium in

Answer 49

While repolarizing, the cell cannot be stimulated again until the membrane is sufficiently negative

Answer 50

The electrical events leading to muscle contraction happens in about 1 millisecond, but the consequential contraction may last for more than 100 times the duration of the electrical signal

Answer 51

Action potential travels down sarcolemma and down t tubules where depolarization causes voltage-sensitive tubule proteins to undergo a change in shape which leads to the opening of calcium release channels in the terminal cisterns Calcium moves into sarcoplasm where it removes inhibitory action of tropomyosin as calcium binds to troponin causing the troponin to change shape which moves tropomyosin away to expose the binding active sites for myosin on the actin thin filaments Myosin binds and cross-bridge cycling commences When the membrane repolarizes, the voltage sensitive tubule proteins regain their resting configuration which consequently closes the calcium release channels of the terminal cisterns Calcium is actively pumped back into the sarcoplasmic reticulum by ATP dependent calcium pumps embedded within the terminal cistern membrane Once calcium levels drop, the inhibitory effect of tropomyosin is restored such that actin and myosin no longer cross bridge, leading to muscle relaxation

Answer 52

A physiological process that links the electrical stimulation of a muscle fiber to its mechanical contraction; While muscle contraction is the ultimate outcome of ECC, the process itself involves a complex series of events that occur at the molecular and cellular levels; Events of the contraction of the muscle 1) Action potential generation 2) Electrical stimulation 3) Depolarization 4) Calcium release 5) Calcium binding to troponin 6) Cross-bridge cycling 7) Relaxation

Answer 53

Tropomyosin: Blocks binding active sites on actin so myosin cant bind Troponin: Calcium binds with troponin causing it to change shape and move tropomyosin away to expose binding sites

Answer 54

Depolarization: Calcium release channels open in terminal cisterns and calcium moves into sarcoplasm Binding: Calcium binds with troponin causing tropomyosin to expose actin binding sites for myosin heads Repolarization: Calcium release channels close and Calcium is pumped back into sarcoplasmic reticulum by ATP dependent calcium pumps within terminal cistern membrane Levels drop: Once calcium levels drop, inhibitory effect of tropomyosin is restored, halting cross bridging and leading to muscle relaxation

Answer 55

Occurs multiple times during a singular muscle contraction; 1) Binding: Tropomyosin physically blocks myosin binding active sites on actin when intracellular calcium is low; As calcium rises intracellularly, it binds to troponin; Once two calcium ions bind to troponin, it changes shape which forces tropomyosin to change position into actin helix groove thus unblocking the myosin binding sites on actin 2) Power Stroke: Power stroke occurs where inorganic phosphate and ADP are released from myosin head allowing myosin to switch to low energy state; This pulls actin filament towards M line 3) Detaching: ATP binds with myosin head causing myosin head to detach 4) Cocking: Hydrolysis of ATP into ADP and inorganic phosphate repositions myosin head in its high energy configuration When nerve impulses arrive at muscle in rapid succession, intracellular calcium quickly elevates and is sustained leading to another contraction before the muscle was completely relaxed; Next contraction will be stronger and/or more sustained

Answer 56

Phosphate and ADP are released from the myosin head when myosin binds to actin; Results in the myosin to swivel or stroke from its high energy configuration to a low energy state; This pulls the actin filament toward the M line

Answer 57

The force exerted by a contracting muscle on an object

Answer 58

The opposing force applied on the muscle by the mass of the object being moved

Answer 59

Each individual muscle fiber is innervated by a branch of a motor axon

Answer 60

Activates all of the muscle fibers innervated by the motor neuron and its axonal branches

Answer 61

The motor neuron combined with all of the individual muscle fibers it innervates; Smaller the motor unit, the finer the control of movement in that muscle; Thus, the muscles controlling the movements of fingers and eyes have small motor units, whereas those controlling the large limb muscles may have very large motor units

Answer 62

Regardless of the number of muscle fibers controlled within a motor unit, a specific motor unit contains only one neuron

Answer 63

The muscle fibers from a single motor unit are typically spread throughout the entire muscle (not clustered together) thus allowing graded control of the entire muscle and not just a small portion of it

Answer 64

The activation process of motor neurons involves the initiation of an action potential along with the axon of a neuron; The axon can branch many times, with each branch synapsing with each muscle fiber controlled by that particular neuron; This causes nearly simultaneous activation of all synapses and thus nearly simultaneous contraction of all muscle fibers

Answer 65

During a muscle contraction, the thick and thin filaments do not change length; Instead thin filaments are pulled past the stationary thick filaments by the power stroke; Since the thin filaments are directly attached to the z-lines, the z-lines of each sarcomere are pulled toward the M-line, thus shortening the sarcomere Occurs as myosin power strokes, releases, attaches again, and then repeats these steps

Answer 66

Relaxed muscle fiber: Thich and thin filaments overlap only at the ends of A bands Contraction: Overlap increases past the ends of A bands at the expense of the H zone and the I bands; This pulls Z lines towards M line, however the A bands do not change in length

Answer 67

Accomplished upon nervous stimulation of the muscle leading to increased sarcoplasmic calcium concentrations and latching of the thick filaments to myosin-binding sites of thin filament actin

Answer 68

Skeletal muscles contract when a motor nerve stimulates an electrical action potential that propagates along the sarcolemma leading to brief rises in intracellular calcium resulting in completion of excitation-contraction coupling

Answer 69

Activate skeletal muscle; Cell bodies are located in the brain or spinal cord; Axons are usually bundled together to form a nerve and extend to the muscle they innervate; Once an axon from a nerve enters a muscle, it divides into several axonal branches which service the muscle fibers

Answer 70

A chemical synapse between a motor neuron and a muscle fiber that allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction; Each muscle fiber has only one neuromuscular junction, or motor end plate, about halfway down the muscle fiber, where the nerve communicates to the muscle; Sarcolemma at neuromuscular junction is greatly folded to increase surface area for an abundance of acetylcholine receptors

Answer 71

Axon terminal; End of the axon; Contain an abundance of synaptic vesicles that are filled with the neurotransmitter (ACh)

Answer 72

The space between the axon terminal and the muscle fiber; Filled with extracellular fluid containing collagen fibers and glycoproteins

Answer 73

1) When a nerve action potential traverses the axon and reaches the axon terminal, depolarization of the axon terminal membrane leads to a calcium influx in the axon terminal which, in turn, leads to the synaptic vesicles fusing with the axon terminal membrane to release acetylcholine into the synaptic cleft; The electrical signal traveling down the nerve is converted to a chemical signal 2) The acetylcholine then diffuses across the synaptic cleft to bind to the acetylcholine receptors on the junctional folds of the sarcolemma; Activation of the acetylcholine receptors opens channels that allow sodium influx into the muscle fiber depolarizing the sarcolemma and causing a muscle action potential; The chemical signal is converted back to an electrical signal 3) The depolarization travels down the sarcolemma in all directions from the neuromuscular junction and down the t tubules leading to the calcium release from the sarcoplasmic reticulum causing muscle contraction

Answer 74

Found in synaptic cleft; Breaks down acetylcholine to acetic acid and choline to terminate the signal allowing for fine control of muscle activation

Answer 75

Refers to the activation of actin-myosin cross bridges; Does not always shorten the muscle; Can either be isotonic or isometric

Answer 76

During isotonic exercises, the muscles contract but joints do not move and muscle fibers maintain a constant length; Exercises are performed against an immovable surface; During isotonic exercises, a body part is moved and the muscle fibers shorten or lengthen; Isotonic contractions help to maintain an upright balanced posture and stabilize joints

Answer 77

In isometric contractions, the thin filaments do not move while the cross bridges form to generate force; Muscle tension remains constant but the muscle length changes

Answer 78

Isotonic contractions are concentric if the muscle length decreases; Example would be the biceps when curling a barbell

Answer 79

Isotonic contractions are eccentric if muscle length increases during contraction; Example would be uncurling the barbell by extending your arm from original curled position

Answer 80

Action potentials arriving at axon terminal trigger the release of acetylcholine into the synaptic cleft of the neuromuscular junction; Acetylcholine diffuses through junctional cleft and binds to acetylcholine gated receptors on motor end plate; Bound receptors open cation-selective ion channels, which depolarizes the muscle end plate and leads to the release of calcium from the sarcoplasmic reticulum; Increases cytosolic calcium sets in motion the biochemical events that underlie contraction

Answer 81

Rapidly hydrolyzed by acetylcholinesterase

Answer 82

Electromyogram; Extracellular recording of electrical activity in a whole muscle; Activation of one or more motor units in a muscle produces an electrical event that is often sufficiently large to be detectable with electrodes applied to the skin surface

Answer 83

Compound muscle potential; Observed in an EMG; The sum of the electrical activity of many individual muscle fibers, all firing at once

Answer 84

Reflects the number and size of motor units that are active

Answer 85

A motor units reaction to a single action potential of its motor neuron; Made of three parts or periods: Latent period, period of contraction, and period of relaxation

Answer 86

First part of of a muscle twitch; Excitation-coupling occurs; Cross bridges are beginning to form, but measurable tension is not yet achieved; The greater the load that is applied to a muscle, the longer the latent period will be

Answer 87

Lasts once tension is measurable until tension peaks; During this time, cross bridges are cycling; The muscle will shorter as the force is being generated by the contraction exceeds the resistance applied to the muscle

Answer 88

Occurs when calcium levels drop in the sarcoplasm; Number of cycling cross bridges decreases and tension declines; A muscle can contract rapidly but will relax more slowly in comparison

Answer 89

Due to differences in the enzyme composition and metabolic properties of different muscles in the body; Example: lateral rectus eye muscle twitches and relaxes more rapidly than the slower soleus muscle

Answer 90

A whole muscle is controlled by firing up to hundreds of motor axons; These axons control movement in a variety of ways to produce smooth strength graded muscle responses: Recruitment, Henneman's size principle, and frequency of action potentials

Answer 91

A way the nervous system controls a muscle; Adjusts the number of motor axons firing, thus controlling the number of twitching muscle fibers

Answer 92

Central nervous system signals small motor units to be recruited first followed by larger and larger motor units as the stimulus increases until all motor units are recruited; As stimulus strength increases so does the muscle contraction until a maximum contraction is reached at which a maximal stimulus stimulates the muscle to contract with as much force as possible and higher stimuli do not increase the strength of contraction; Explains how the same muscle can control fine delicate movements and also perform powerful heavy maneuvers

Answer 93

Henneman's size principle; Low threshold, easily excitable motor neurons control small motor units, and high threshold, least excitable motor neurons control large motor units

Answer 94

Nervous system controls muscle contraction by varying the frequency of action potentials in the motor axons; Stimulation intervals greater than 200ms, between 200 and 75ms, higher stimulation frequencies, and even higher stimulation frequencies

Answer 95

Intracellular calcium is restored to baseline levels between action potentials and contraction consists of separate twitches

Answer 96

Calcium in muscle is still above baseline levels when next action potential arrives; Muscle fiber is not completely relaxed and the next contraction is stronger than normal; Summation

Answer 97

Higher than 75ms; Degree of summation increases leading to sustained graded contractions that can increase in size and length

Answer 98

Even higher than 75ms; Muscle has no time to relax at all between successive stimuli leading to a smooth contraction many times stronger than a single twitch; Tetanic contraction

Answer 99

Skeletal muscle maintains a baseline tone where relaxed muscle will be in a state of higher contraction; This does not give rise to movements but keeps muscles healthy, firm, and primed to respond

Answer 100

A technique that measures the electrical activity of muscles and nerves controlling the muscles; Data recorded is an EMG; Size and shape of waveform measured provides information about ability of muscle to respond when nerves are stimulated; Used when people have symptoms of weakness and examination shows impaired muscle strength; Can also help to differentiate muscle weakness caused by neurological disorders from other conditions

Answer 101

Provides a depiction of the timing and pattern of muscle activity during complex movements; Raw surface EMG signal reflects the electrical activity of the muscle fibers active at that time; Motor units fire asynchronously and it is possible to detect the contributions of individual motor units to the EMG; As strength of muscle contraction increases, intensity of action potentials increase and the raw signal may represent the electrical activity of thousands of individual fibers

Answer 102

A phenomenon in which contraction of the muscle leads to some minor contractile activity in the antagonist muscle; Likely helps to stabilize the joint and generate smooth contractions and relaxations against the load on the muscle

Answer 103

1) Creatine phosphate directly phosphorylating ADP to ATP 2) Anaerobic glycolysis 3) Aerobic respiration

Answer 104

Interacts with ADP to transfer a phosphate and energy to the ADP to form ATP and creatine; Muscles store up to 3 times more creatine phosphate than ATP; Stored ATP and creatine phosphate can power a muscle for only about 10 seconds during very vigorous activity; Creatine pathway reaction is readily reversible so during periods of rest the muscle will regenerate creatine phosphate by reversing the reaction; Surges of intense activity rely on stored ATP and creatine phosphate

Answer 105

Glycogen from muscle stores will be broken down to glucose and further broken down with glucose from the blood to provide ATP; Glycolysis is first phase of glucose break-down; Does not require oxygen for completion; Glucose is broke down to pyruvate molecules and forms 2 ATP per glucose; At about 70% of maximal contraction, a muscle will become too bulged so it will compress blood vessels decreasing oxygen delivery; When this happens, pyruvate is converted back to lactic acid, which exits the muscle and can be converted by the liver back to glucose; Slightly longer duration but high intensity exercises are powered by mostly anaerobic glycolysis

Answer 106

If sufficient oxygen is available, the pyruvate from the glycolysis will enter the TCA cycle and oxidative phosphorylation in the mitochondria to produce more ATP; Completely breaks down glucose to produce carbon dioxide, water, and about 34 ATP per glucose; Slow because of all steps and intermediates required, but produces many ATP; As long as oxygen is available, muscles will perform aerobic pathways

Answer 107

Very fast but does not produce much ATP; Can power muscle for about 40 seconds; Fatty acids can be burned and are a major energy source, especially after 30 minutes of contractile activity; When activity in muscle creates a demand that exceeds the speed that oxidative pathways can be completed, metabolism will switch to anaerobic pathways

Answer 108

The amount of times a muscle can contract using aerobic pathways

Answer 109

The point at which metabolism in the muscle switches to anaerobic glycolysis

Answer 110

In isolated muscles, depletion of energy and metabolite stores result in fatigue; Ionic imbalances across the muscle cell membranes can also lead to fatigue; Example: potassium accumulation in t tubules can change the membrane potential and disturb calcium release from the terminal cisterns; lactic acid accumulation can also lead to fatigue; Fatigue occurs in muscles faster when have a lower capacity for oxidative metabolism; Fatigue can also occur because the motor drive from the brain is reduced, rather than as a result of an appreciable depletion of the muscle energy reserves

Answer 111

The more motor units recruited, the greater the force of contraction; The larger the size of a muscle fiber (greater diameter), the greater the force; Exercise can increase the force of contraction because exercise causes muscle fibers to hypertrophy (increase in size or volume due to enlargement of cells); Contraction summation due to increased stimulation frequency will also increase force of contraction; Extent of stretch to the muscle will also determine contractile strength

Answer 112

At the optimal length-tension relationship, the muscle will be slightly stretched so that the overlap of the thick and thin filaments is optimal; The body joints usually prevent a muscle from being stretched beyond degree at which the thick and thin filaments can overlap

Answer 113

Muscles vary in how fast and for how long they can contract before fatigue sets in; The difference between slow and fast fibers is partially determined by the responsiveness of their motor neurons but is largely due to the speed at which myosin ATPases can split ATP in the three muscle fiber types; Contraction duration will be influenced by how fast a muscle type can pump calcium back into the sarcoplasmic reticulum

Answer 114

Muscle fibers can be classified by the metabolic pathway they mainly use during contraction; Oxidative fibers rely mostly on aerobic pathways and glycolic fibers mainly rely on anaerobic glycolysis and creatine phosphate

Answer 115

Slow oxidative fibers, fast oxidative fibers, or fast glycolic fibers

Answer 116

Fatigue is correlated with depletion of ATP, nutrients, and oxygen in muscle fibers, but is also due to perception of conditions in the muscle by the brain; The perception of fatigue can be influenced by verbal encouragement

Practical Exam 2 - AOIs and Muscles Flashcards

(140 cards)