pre formulating drug solution Flashcards
(37 cards)
what is a solution?
‘a mixture of two or more components that form a homogonous molecular dispersion’
what are the units for solutions?
weight concentration or molarity
what phase is solution and what does it mean?
what is a saturated solution?
‘where the solute is at the limit of its solubility at a certain temperature or pressure’
phenol is 100 times mroe soluble in water than benzene
change to molecular structure effects solubility
what changes can effect the solubility?
structure of molecule
substituents on solutes
how do substituents effect the solubility?
change intermolecular forces
interactions between solutes and water
what are the properties of substituents?
either hydrophilic or hydrophobic
the position of substituents effects solubility
main types of solid in liquid solutions?
‘like dissolves like’
what is used to predict solubility
polarity
what are the factors involved in predicting solubility?
what is used to improve solubility?
examples of amphoteric drugs?
what do amphoteric drugs?
when do you use the base equation?
ph below isoelectric point
when do you use the acid equation?
ph above isoelectric point
what happens to the solubility of a weak base as ph increases?
what happesn t solubility to weak acid as ph increases?
what happens to isoelctric point as solubility increases?
what is the definition of solubility?
how does a solid drug get in systemic circulation?
