Preterm Infant Flashcards

1
Q

What is a preterm birth?

A

Before 37 weeks gestation

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2
Q

What is a post term birth?

A

After 42 completed weeks of gestation

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3
Q

What is an extremely preterm birth?

A

<28 weeks

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4
Q

What is a very preterm birth?

A

<32 weeks

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5
Q

What is a preterm birth?

A

<37 weeks

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6
Q

What impact did the smoking ban have on premature birth?

A

Fell by 10%

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7
Q

When do over half the childhood deaths occur?

A

1st year of life; strongly influenced by preterm delivery and low birth weight (RF; maternal age, smoking, disadvantaged circumstances)

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8
Q

If you are born before 32 weeks; what times more likely are you to die?

A

10x

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9
Q

Which babies are most at risk for preterm birth?

A

Black or asian mothers
Teenage and geriatric mothers (>40)
Poverty

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10
Q

How many births are preterm?

A

1 in 10

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11
Q

What are the causes of preterm birth?

A
Spontaneous
Multiple pregnancy
Preterm prelabour rupture of membranes
Pregnancy assoc hypertension 
IUGR
Antepartum haemorrhage 
Cervical incompetence/ uterine malformation
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12
Q

What are risk factors for preterm birth?

A
> 2 preterm deliveries previously
Abnormally shaped uterus 
Multiple pregnancy
<6 month interval between pregnancies
Conceiving through IVF
Smoking, drinking alcohol, illicit drug use
Poor nutrition, high BP, diabetes
Multiple miscarriages or abortions
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13
Q

What extra support will all preterm babies require?

A
More help to stay warm 
More fragile lungs
Don't breathe effectively 
Fewer reserves
Delay cord clamping if possible
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14
Q

How can preterm babies be kept warm?

A

Plastic bag under a radiant heater
Skin to skin care
Transwarmer mattress
Prewarmed incubator

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15
Q

What are common problems of prematurity?

A
Temp control
Feeding/ nutrition 
Sepsis 
System immaturity/ dysfunction 
Metabolic
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16
Q

What system immaturity/ dysfunction affects premature babies?

A

Resp distress syndrome
Patent ductus arteriosus
Intraventricular haemorrhage
NEC

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17
Q

What is an independent risk factor for neonatal death?

A

Hypothermia

Increases severity of all preterm morbidities

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18
Q

Why is thermal regulation ineffective in neonates?

A

Low BMR
Minimal muscular activity
Subcut fat insulation is negligible
High ratio of surface area to body mass

19
Q

What is the triangle in terms of temp control in babies?

A

Hypothermia
Hypoglycemia
Hypoxia

20
Q

Why will hypoglycemia lead to hypoxia?

A

Decreased surfactant production
Pulmonary vasoconstriction
Increased work of breathing
Resp distress

21
Q

Why can hypothermia lead to hypoxia?

A
Increased metabolism
Decreased o2 consumption 
Increased RR
O2 demand greater than supply
Anaerobic metabolism 
Acidosis 
Hypoxia
22
Q

Why can hypothermia lead to hypoglycemia?

A
Increased metabolism
Increased glucose uptake
Increased use of glycogen stores
Depleted glycogen stores
Hypoglycaemia
23
Q

Why is there an increased risk of nutritional compromise in neonates?

A

Limited nutrient reserves
Gut immaturity
Immature metabolic pathways
Increased nutrient demands

24
Q

What is the best form of nutrition for preemies?

A

Breast milk; can use donor milk bank

25
What will early onset neonatal sepsis suggest?
Bacteria acquired before and during delivery
26
What will late onset neonatal sepsis suggest?
Acquired after delivery | Nosocomial or community
27
Which bugs can cause early onset neonatal sepsis?
GBS | Gram negs; e.coli
28
Which bugs can cause late onset neonatal sepsis?
Coagulase neg staph Gram negs Staph aureus
29
What are the risks of infection assoc with prematurity?
Immature immune system Intensive care environment Indwelling tubes and liens
30
How can infections in neonates be managed?
``` Prevention Hand washing Super vigilant and infection screening Judicious use of antibiotics Supportive measures ```
31
What are the respiratory complications of prematurity?
Resp distress syndrome Apnoea of prematurity Bronchopulmonary dysplasia
32
What can cause resp distress syndrome?
Primarily; surfactant deficiency, structural immaturity Secondary pathology Alveolar damage; formation of exudate from leaky capillaries
33
What are the clinical features of RDS?
Resp distress Tachypnoea; grunting, intercostal recessions, nasal flaring, cyanosis Worsens over min- hours
34
What is the management of RDS?
Maternal steroids when in utero Surfactant Ventilation; invasive/ non invasive
35
What is the imaging of choice to monitor interventricular haemorrhages in neonates?
Anterior fontanelle via USS
36
What are the classification/ grades of intraventricular haemorrhages?
Grade 1 and 2; neurodevelopmental delay up to 20%, mortality 10% Grade 3 and 4; neurodevelopmental delay up to 80%, mortality 50%
37
What are the consequences of NEC?
Gut is necrotic Can perforate Sepsis DIC
38
When will the retina of babies fully develop?
6-8 weeks after delivery
39
What are the early metabolic complications seen in preterms?
Hypoglycaemia | Hyponatraemia
40
What is the late metabolic complication seen in preterms?
Osteopenia of prematurity
41
Describe the survival in extreme preterms?
``` Survival without disability of admissions for neonatal care: 22 weeks; 5% 23 weeks; 14% 24 weeks; 28% 25 weeks; 47% 26 weeks; 61% ```
42
What are the short term complications of preterm birth?
Respi GIT CV complications
43
What are the long term sequelae of preterm birth?
Neurodevelopmental disabilities such as CP