Neonatal sepsis

Question 1

What are the perinatal risk factors to neonatal sepsis?

Answer 1

GBS colonization 
PROM >18 hrs 
Significant GBC bacteriuria during pregnancy
Maternal temp >38 in labour
Chorioamnionitis
Sustained intrapartum foetal tachycardia

Question 2

Physical appearance of a neonate with sepsis?

Answer 2

Resp distress; grunting, retractions, pallor, cyanosis
Hypotension
Delayed CRT
Hypoxia
Lethargy
Poor feeding
Indifferent to pain

Question 3

What can be seen on vital signs of a neonate with sepsis?

Answer 3

Tachypnoea
Tachycardia
Hypotension
Temp; high, normal or low

Question 4

What Ix should be performed in suspected neonatal sepsis

Answer 4

Blood culture, LP, urine culture
BG
FBC
CRP
U+Es

Question 5

What bugs cause neonatal sepsis?

Answer 5

GBS
E,coli
S.aureus/ epi
Enterococcus
Klebsiella

Question 6

Tx of neonatal sepsis?

Answer 6

Benzylpenicillin
Gentamicin
If due to staph infection lines; vancomycin/ fluclox