Primary Biliary Cholangitis (PBC)

Question 1

Primary biliary cirrhosis (PBC) =

Answer 1

Long-term liver disease in which thebile ducts in the liver become damaged. This gradually leads to a build-up of bile in the liver, which can damageit and eventually lead to cirrhosis. This is more common in females.

Question 2

Primary biliary cirrhosis (PBC) = Male or Females?

Answer 2

This is more common in females.

Question 3

Primary biliary cirrhosis Pathology

Answer 3

Granulomatous Inflammation involving the bile ducts, Loss of intra-hepatic bile ducts, Progression to cirrhosis.

Question 4

Primary biliary cirrhosis Complications:

Answer 4

Complications: Sjogren/Sicca Syndrome (in 70% of people)

Hepatocellular Cancer (20x fold increase)

Portal hypertension

Malabsorption.

Question 5

Primary biliary cirrhosis - M Rule:

Answer 5

M Rule: IgM elevated, Middle aged females, anti-Mitochondrial antibodies +ve, M2 subtype

Question 6

Primary biliary cirrhosis - Symptoms:

Answer 6

usually asymptomatic
may be Fatigue
Itchy Skin
Dry eyes
Dry mouth
Abdominal Pain (Right upper quadrant)

Question 7

Primary biliary cirrhosis -Treatment:

Answer 7

UDCA (Ursodeoxycholic Acid)

Liver Transplant for end-stage liver disease