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Flashcards in Primary Bone tumors Deck (17):
1

Mutation in Achondroplasia

Constitutive activation of fibroblast growth factor receptor (FGFR3)

inhibits chondrocyte proliferation

2

Most common malignant primary bone tumor in children

Osteosarcoma
(Osteogenic sarcoma)

3

Most common benign bone tumor

Osteochondroma

4

11;22 translocation

Ewing sarcoma
causing fusion protein EWS- FLI 1

5

Rb mutation

Osteosarcoma

6

"sunburst" pattern on x-ray

Osteosarcoma

7

"soap bubble" appearance on x-ray

Giant Cell Tumor
Osteogenic sarcoma

"clean like soap"

8

"Onion skin" appearance of bone

Ewing Sarcoma

9

May actually be a hamartoma

Osteochondroma
"chunk of bone"

10

Codman's triangle on x-ray

Osteosarcoma
from elevation of periosteum

11

What causes short limbs in Achondroplasia

Failure of longitudinal bone growth (enchondral fusion

12

How is achondroplasia passed on

>85% of mutations occur sporadically
autosomal dominant with full penetrance (homozygosity lethal)

13

Males

Osteochondroma

14

20-40 years old

Giant Cell Tumor
Osteoclastoma

15

Multinucleated giant cells

Giant Cell tumor
Osteoclastoma

16

Bimodal distribution: 10-20 years (primary)
>65 (secondary)

Osteosarcoma (osteogenic sarcoma)

17

Boys

Ewing Saroma