Primary Progressive Aphasia Flashcards Preview

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Flashcards in Primary Progressive Aphasia Deck (13):
1

PPA Variants

1. Progressive Non-Fluent Aphasia (PNFA)

2. Semantic Dementia (SD)

3. Logopenic Progressive Aphasia (LPA)

2

Progressive Non-Fluent Aphasia (PNFA)

- Most Common Deficits

- agrammatic output

• motor speech impairments
(apraxia of speech, dysarthria)

• impaired comprehension of
complex sentences

• anomia (particularly for verbs)

3

Progressive Non-Fluent Aphasia (PNFA)

- Preserved Behaviors

• semantic processing

• comprehension for
single-words and simple
sentences

• auditory-verbal shortterm
memory (AVSTM)

4

Progressive Non-Fluent Aphasia (PNFA)

- Neuroanatomy

Predominant left posterior frontoinsular
atrophy

5

Progressive Non-Fluent Aphasia (PNFA)

- Pathology

• Corticobasa degeneration

• Progressive supranuclear palsy

6

Semantic Dementia

- Most Common Deficits

• severe anomia

• poor single-word comprehension
(particularly for low-frequency
items)

• multi-modal semantic memory
impairment

• surface dyslexia

7

Semantic Dementia

- Preserved Behaviors

• motor speech

• expressive syntax
(fluency)

• sentence comprehension

8

Semantic Dementia

- Neuroanatomy

Predominant left anterior temporal lobe atrophy

9

Semantic Dementia

- Pathology

Frontotemporal dementia related
pathology

10

Logopenic Progressive Aphasia (LPA)

- Most common deficits

• anomia

• poor phase and sentence repetition
due to impaired AVSTM

• phonological errors in
spontaneous speech and naming

11

Logopenic Progressive Aphasia (LPA)

- Preserved Behaviors

• motor speech

• semantic processing

• single-word
comprehension

12

Logopenic Progressive Aphasia (LPA)

- Neuroanatomy

Predominant left posterior perisylvian or
parietal atrophy

13

Logopenic Progressive Aphasia (LPA)

- Pathology

Alzheimer’s disease