Pro and Anti-Inflammatory Drugs

Question 1

Are prostaglandins anti-inflammatory or pro-inflammatory?

Answer 1

pro-inflammatory

Question 2

What prostaglandin is an Agonist at prostaglandin E1 receptors on parietal cells (GI system)?

Answer 2

Misoprostol

Question 3

What prostaglandin is an agonist at prostacyclin receptors, where binding increases cAMP production and causes pulmonary vasodilation?

Answer 3

Iloprost

Question 4

What prostaglandin binds to prostaglandin FP receptors?

Answer 4

Latanoprost, Travoprost, Bimatoprost

Question 5

Main effects for misoprostol (2)

Answer 5

1) Reduces gastric acid secretion
2) Stimulates mucus and bicarbonate production

Question 6

Main effects for Iloprostol

Answer 6

Pulmonary vasodilation

Question 7

Main effects for Latanoprost, Travoprost, Bimatoprost (2)

Answer 7

1) Increase uveoscleral outflow (not trabecular)
2) Reduce IOP

Question 8

When would you use misoprostol?

Answer 8

Labor induction because it protects the Gi system and mucosal lining during chronic NSAID treatment

Question 9

What drug would you take for pulmonary hypertension?

Answer 9

Iloprost

Question 10

What drugs would you take for glaucoma treatment?

Answer 10

Latanoprost, travoprost, bimatoprost

Question 11

How is Iloprost administered?

Answer 11

Inhalation

Question 12

What drug may causes Diarrhea, abdominal pain, headache, and may induce abortion?

Answer 12

Misoprostol

Question 13

What pro-inflammatory drug causes headache, dizziness, flushing?

Answer 13

iloprost

Question 14

What drug causes blurred vision, increase iris pigmentation, increased pigment of eyelashes, and eye redness?

Answer 14

Latanoprost, travoprost, bimatoprost

Question 15

Is aspirin pro or anti-inflammatory?

Answer 15

Anti-inflammatory

Question 16

What are the main effects of aspirin? (5)

Answer 16

1) Analgesic, anti-inflammatory, anti-pyretic

2) Increased alveolar ventilation/respiration

3) Increased gastric acid production (bad)

4) Decrease in protective GI mucous (bad)

5) Inhibits platelet aggregation

Question 17

When would you use aspirin?

Answer 17

treat pain, anti-inflammatory, and reduce fever

Question 18

What is the only irreversible NSAID?

Answer 18

aspirin

Question 19

Adverse effects of aspirin

Answer 19

Gi issues
Potential risk of serious CV thrombosis, MI, and stroke
Prolong bleeding
Hypersensitivity
Drug interactions

Question 20

When should you avoid taking aspirin?

Answer 20

In children and teenagers with viral infection

Question 21

A child has Reye syndrome (hepatitis with edema), what would you give them?

Answer 21

NSAID other than aspirin

Question 22

Are COX-2 NSAIDS anti-inflammatory or pro-inflammatory?

Answer 22

anti-inflammatory

Question 23

What are COX-2 NSAIDS main effects?

Answer 23

• Analgesic, anti-inflammatory, anti-pyretic
• Increased alveolar ventilation/respiration
• Inhibits platelet aggregation

Question 24

Do COX-2 NSAIDS have more or less side effects?

Answer 24

Less side effects but can still cause GI issues

Question 25

What drug is a DMARD and is used in cancer treatment?

Answer 25

Methotrexate

Question 26

What DMARD has subQ/IV administration and cannot be used with IL-1 antagonists (anakinra)?

Answer 26

TNF inhibitors

Question 27

What DMARD has a subQ injection once a day and can't be combined with TNF inhibitors?

Answer 27

Anakinra

Question 28

What do DMARDS treat?

Answer 28

Rheumatoid arthritis and other chronic inflammatory diseases

Question 29

What kind of adverse effects does hydroxychloroquine have?

Answer 29

GI upset Skin rash HA Bull's eye maculopathy ○ Unknown cause ○ Permanent vision loss ○ Requires yearly exam with central VF/OCT

Question 30

What drug can cause Bull's eye maculopathy?

Answer 30

Hydroxychloroquine

Question 31

Adverse effects of TNF inhibitors (4)

Answer 31

1) Increased infection risk 2) Cannot administer with live vaccines 3) Can worsen pre-existing HF 4) Increased risk of cancer/lymphoma