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Flashcards in Protein Structure And Function Deck (11)
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1

What is the definition of protein?

Long chain of covalently linked amino acids

Linked together via a polypeptide bond

2

What dictates the non-covalent bonds?

The different amino acid side chains

3

The covalent bonds gives the chain ______ and _____

Non covalent bonding _________ ______

Flexibility and rotation

Maintains shape

4

What pushes hydrophobic molecules together and arranges proteins into compact conformations?

Hydrophobic forces

5

What helps the protein fold correctly and bind to the correct proteins?

Molecular chaperones

6

Improperly folded proteins result in what?

Alzheimer’s ( protein aggregates that form beta amyloid plaques)

Huntington’s (inclusion bodies are formed)

Creuzfeld-Jakobs disease (infectious protein (prion disease))

Parkinson’s (lewey bodies formed, aggregate into amyloid fibrils)

7

What are the three folding patterns?

Alpha helix

Beta sheets

Hydrogen bonding

8

What are the four different levels of protein organization?

Primary

Secondary

Tertiary

Quaternary

9

What makes up a primary structure?

Amino acid sequence

10

What makes up a secondary structure of protein?

Alpha helix and beta sheets

11

What makes up a tertiary structure?

Polypeptide with alpha helixes, beta sheets and random coils

Folded proteins