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ZPharmacology > Psych Pharm EC > Flashcards

Psych Pharm EC Flashcards

1
Q

Alcohol withdrawal treatment

A

Benzodiazepines

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2
Q

Anxiety preferred treatment

A

SSRIs, SNRIs, Buspirone

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3
Q

ADHD preferred treatment

A

Methylphenidate, amphetamines

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4
Q

Bipolar disorder preferred drugs

A

Lithium
Valproic acid
Carbamazepine
Atypical antipsychotics

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5
Q

Bulimia preferred drugs

A

SSRIs

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6
Q

Depression preferred drugs

A 
SSRIs
SNRIs
TCAs
Buspirone
Mirtazapine (esp. w/ insomnia)
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7
Q

OCD preferred drugs

A

SSRI

Clomipramine

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8
Q

Panic disorder preferred drugs

A

SSRIs
Venlafaxine
Benzodiazepines

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9
Q

PTSD preferred drugs

A

SSRIs

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10
Q

Schizophrenia preferred drugs

A

Antipsychotics

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11
Q

Social phobias preferred drugs

A

SSRIs

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12
Q

Tourette’s syndrome preferred drugs

A

Antipsychotics (esp. haloperidol, risperidone)

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13
Q

Methylphenidate, Dextroamphetamine, Methamphetamine (MOA, Use)

A

CNS stimulants
Increase catecholamines at synaptic cleft, (NE and dopamine)

ADHD, narcolepsy, appetite control

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14
Q

Haloperidol, Fluphenazine, Thioridazine, Chlorpromazine (MOA, Use, Tox)

A

Antipsychotics
Block D2 receptors (increase cAMP)

Schizophrenia (positive symptoms)
Psychosis
Acute mania
Tourette’s

Causes dyskinesias, galactorrhea, dry mouth, constipation, hypotension, and sedation

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15
Q

Which antipsychotics are high potency? What kind of side effects do they primarily produce?

A

Trifluoperazine, Fluphenazine, and Haloperidol “Try to Fly High)

Neurologic side effects

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16
Q

Which antipsychotics are low potency? What kind of side effects do they primarily produce?

A

Chlorpromazine, Thioridazine (Cheating Thieves and Low)

Anticholinergic, Antihistamine, and a-1 blockade effects

17
Q

Rigidity, myoglobinuria, autonomic instability, hyperpyrexia,

A

Neuroleptic malignant syndrome

Treat w/ Dantrolene + Bromocriptine

18
Q

Stereotypic oral-facial movements as a result of long-term antipsychotic use.

A

Tardive dyskinesia

Often irreversible

19
Q

Antipsychotic causing corneal deposits

A

Chlorpromazine

20
Q

Antipsychotic causing retinal deposits

A

Thioridazine

21
Q

Olanzapine, Clozapine, Risperidone, Quetiapine, Aripiprazole, Ziprasidone (MOA, Use, Tox)

A

Atypical antipsychotics
5-HT2 and dopamine blockers

Schizophrenia (both positive and negative symptoms)
Bipolar disorder
OCD
Anxiety disorder
Depression
Mania
Tourette's

Fewer extrapyramidal and anticholinergic side effects

22
Q

Atypical antipsychotics causing weight gain/diabetes

A

Olanzapine/Clozapine

23
Q

Atypical antipsychotic that may cause agranulocytosis and seizure

A

Clozapine

24
Q

Atypical antipsychotic that may prolong QT interval

A

Ziprasidone

25
Q

Lithium (Use, Tox)

A

Mood stabilizer for bipolar disorder
Blocks relapse and acute manic events
Also treats SIADH

Movement (tremor)
Nephrogenic diabetes insipidus 
Hypothyroidism 
Pregnancy problems
Teratogen (Ebstein anomaly)
26
Q

Buspirone (MOA, Use)

A

Stimulates 5-HT1a receptors

Generalized anxiety disorder

  • does not cause sedation, addiction, or tolerance
  • takes 1-2 weeks to take effect
  • Does not interact with alcohol
27
Q

Fluoxetine, Paroxetine, Sertraline, Citalopram (MOA, Use, Tox)

A

SSRIs

Depression, GAD, Panic disorder, OCD, Bulimia, Social phobia, PTSD

GI distress, sexual dysfunction,
Can cause Serotonin syndrome with any drug that increases serotonin

28
Q

Serotonin syndrome (Cause, Findings, Treatment)

A

Caused by combo of SSRI w/ MAO inhibitors, SNRIs, or TCAs

Hyperthermia, Confusion, Myoclonus, CV collapse, Flushing, Diarrhea, Seizures

Treatment: Cyproheptadine (5-HT2 receptor antagonist)

29
Q

Venlafaxine, Duloxetine (MOA, Use, Tox)

A

SNRIs (5-HT and NE)

Depression
GAD (Venlafaxine)
Panic disorder (Venlafaxine)
Diabetic peripheral neuropathy (Duloxetine)

Increases BP, Stimulant effect, nausea

30
Q

Amitriptyline, Nortriptyline, Imipramine, Desipramine, Clomipramine, Doxepin, Amoxapine (MOA, Use, Tox)

A

TCAs (block NE and serotonin reuptake)

Major depression
Bedwetting (Imipramine)
OCD (Clomipramine)
Fibromyalgia

Sedation, a-1 blocking effects, anticholinergic effects,
CONVULSIONS, COMA, CARDIOTOXICITY

31
Q

Treatment for TCA induced cardio toxicity

A

NaHCO3

32
Q

Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline (MOA, Use, Tox, Contraindications)

A

Selective MAO-B inhibitors (MOA Takes Pride In Shanghai)
Increase NE, Serotonin, Dopamine

Atypical depression
Anxiety
Hypochondriasis

Hypertensive crisis (esp. w/ tyramine food ingestion) 
CNS stimulation

CONTRAINDICATED W/ SSRIs, TCAs, St. John’s Wort, MEPERIDINE, & DEXTROMETHORPHAN (to prevent serotonin syndrome)

33
Q

Bupropion (MOA, Use, Tox)

A

Atypical antidepressant
Increase NE and Dopamine (unknown MOA)

Depression
Smoking cessation

Stimulant effects, headache, seizure in bulimic
NO SEXUAL SIDE EFFECTS

34
Q

Mirtazapine (MOA, Use, Tox)

A

Atypical antidepressant
alpha-2 antagonist (increase NE/5HT release)

Depression (w/ insomnia, elderly, anorexic)

Sedation (used in insomnia), Increase appetite/weight gain (desirable in elderly and anorexic), Dry mouth

35
Q

Maprotiline (MOA, Use, Tox)

A

Atypical antidepressant
Blocks NE reuptake

Depression

Sedation, Orthostatic hypotension

36
Q

Trazodone (MOA, Use, Tox)

A

Atypical antidepressant
Inhibits 5-HT reuptake

Insomnia (primary use)
Depression (high doses)

Sedation, Nausea, PRIAPISM, Postural hypotension

ZPharmacology (23 decks)

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