Reproductive Pharm EC Flashcards Preview

ZPharmacology > Reproductive Pharm EC > Flashcards

Flashcards in Reproductive Pharm EC Deck (18):
1

Leuprolide (MOA, Use, Tox)

GnRH analog (agonist if pulsatile, antagonist if continuous)

Infertility (pulsatile)
Prostate cancer (continuous-used w/ flutamide)
Uterine fibroids (continuous)
Precocious puberty (continuous)

Antiandrogen effects, N/V

2

Testosterone, Methyltestosterone (MOA, Use, Tox)

Androgen agonist

Hypogonadism (promote secondary sex characteristics)
Burn or injury (stimulates anabolism)

Masculinization in females,
Reduces intratesticular testosterone in males by inhibiting release of LH - gonadal atrophy
Premature closure of epiphyseal plates
Increase LDL, decrease HDL

3

Finasteride (MOA, Use)

Antiandrogen
5-a-reductase inhibitor (inhibit conversion to DHT)

BPH
Promotes hair growth

4

Flutamide (MOA, Use)

Antiandrogen
Nonsteroidal testosterone receptor antagonist

Prostate carcinoma

5

Ketoconazole (MOA, Use, Tox)

Inhibits steroid synthesis (17,20 desmolase)

PCOS to prevent hirsutism

Gynecomastia
Amenorrhea

6

Spironolactone (MOA, Use, Tox)

Inhibits steroid binding (antiandrogen)

Treats hirsutism in PCOS

Gynecomastia
Amenorrhea

7

Ethinyl, Estradiol, DES, Mestranol (MOA, Use, Tox)

Bind estrogen receptors (estrogens)

Hypogonadism or ovarian failure
Menstrual abnormalities
HRT in postmenopausal women
Use in men w/ andro dependent prostate cancer

Increase endometrial cancer risk, bleeding in postmenopausal women, increased risk of thrombi,

CONTRAINDICATED IN ER+ BREAST CANCER AND HISTORY OF DVTs

8

Clomiphene (MOA, Use, Tox)

SERM
Partial estrogen receptor agonist in hypothalamus

Stimulates ovulation (treats infertility and PCOS)

Hot flashes, ovarian enlargement, multiple pregnancies, visual disturbances

9

Tamoxifen (MOA, Use)

SERM
Antagonist at breast,

ER+ breast cancer

10

Raloxifene (MOA, Use)

SERM
Antagonist at breast, agonist at bone

Osteoporosis
ER+ breast cancer

11

Anastrozole/Exemestane

Aromatase inhibitors used in postmenopausal women with breast cancer

12

Progestins (MOA, Use)

Bind progesterone receptors and reduce growth and increased vascularization of endometrium

Used in oral contraceptives
Endometrial cancer
Abnormal uterine bleeding

13

Mifepristone/RU-486 (MOA, Use, Tox)

Progestin antagonist

Abortion (w/ misoprostol (PGE1)

Heavy bleeding, GI effects, Abdominal pain

14

Oral contraception (Synthetic progestins, estrogen)

Inhibit LD/FSH and prevent estrogen surge (no ovulation)

Progestins cause thickening of cervical mucus and inhibit endometrial proliferation

CONTRAINDICATIONS: Smokers >35, Hx of thromboembolism/stoke, or history of estrogen-dependent tumor

15

Terbutaline (MOA, Use)

Beta-2 agonist that relaxes the uterus

Reduces premature uterine contractions

16

Tamsulosin (MOA, Use)

alpha-1a,d antagonist (inhibit SM contraction)

BPH

17

Sildenafil, Vardenafil (MOA, Use, Tox)

Inhibit PDE5, increase cGMP, SM relaxation in corpus cavernosum, increased blood flow

Erectile dysfunction

Headache, flushing, dyspepsia, vision changes
LIFE THREATENING HYPOTENSION W/ NITRATES

18

Danazol (MOA, Use, Tox)

Synthetic androgen that acts as partial agonist

Endometriosis and hereditary angioedema

Weight cain, edema, acne, hirsutism, masculinization
Decrease HDL levels, hepatotoxicity