Teratogens EC Flashcards
Period most susceptible to teratogens.
3-8th weeks
Before week 3=all or none defects
After week 8=growth and function affected
ACE inhibitors effect on fetus
Renal damage
Alkylating agents effect on fetus
Absence of digits, multiple anomalies
Aminoglycosides effect on fetus
CN VIII toxicity
Carbamazepine effect on fetus
Neural tube defects Craniofacial defects Fingernail hypoplasia Developmental delay IUGR
Diethylstilbestrol (DES) effect on fetus
Vaginal clear cell adenocarcinoma
Congenital Mullerian anomalies
Folate antagonists effect on fetus
Neural tube defects
Lithium effect on fetus
Ebstein’s anomaly (Atrialized right ventricle)
Phenytoin effect on fetus
Fetal hydantoin syndrome; Microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, mental retardation
Tetracyclines effect on fetus
Discolored teeth/bone problems
Thalidomide effect on fetus
Limb defects (“flipper limbs”)
Valproate effect on fetus
Inhibition of maternal folate absorption (neural tube defects)
Warfarin effect on fetus
Bone deformities
Fetal hemorrhage
Abortion
Ophthalmologic abnormalities
(Use heparin in preg.)
Mental retardation, developmental retardation, microcephaly, holoprosencephaly, facial abnormalities, limb dislocation, and heart/lung fistulas.
Fetal alcohol syndrome
Cocaine effect on fetus
Abnormal placenta development/Abruption
Fetal addiction
