Psychopharmacology

Question 1

Selective Serotonin Reuptake Inhibitors (SSRI)

Answer 1

Fluoxetine
Paroxetine
Sertraline
Citalopram
Escitalopram

Question 2

Side effects of SSRIs

Answer 2

Sexual dysfunction, drowsiness, weight gain, insomnia

Question 3

Side effect specific to citalopram

Answer 3

QT prolongation

At high doses

Question 4

Uses for SSRIs?

Answer 4

Antidepressant
Anxiolytic
OCD
Frontotemporal dementia (even without depression)

Question 5

Serotonin-Norepinephrine Reuptake Inhibitors (SNRI)

Answer 5

Venlafaxine
Duloxetine

Question 6

Side effects of SNRIs

Answer 6

Less sexual dysfunction and weight gain than SSRIs
Stomach issues

Question 7

What disease can duloxetine be used for?

Answer 7

Diabetic peripheral neuropathy

Question 8

Tricyclic antidepressants (TCA)

Answer 8

Imipramine
Amitriptyline
Nortriptyline

Question 9

Side effects of TCAs

Answer 9

Anticholinergic effects (dry mouth)
Anti-histaminergic effect (sedation, weight gain)
Insomnia
QT prolongation
Sexual dysfunction

Question 10

Which TCA is least likely to cause weight gain and sedation?

Answer 10

Nortriptyline

Relatively weak H1 receptor blockade

Question 11

Atypical antidepressants

Answer 11

Bupropion
Trazodone
Mirtazapine

Question 12

Side effects of bupropion

Answer 12

Insomnia, headache, tremor, weight loss
Does have a risk to abuse

Question 13

What is a major concern for bupropion in a neurologic setting?

Answer 13

Can increase risk of seizures
Lower seizure threshold

Question 14

Besides depression, what else can bupropion be used for?

Answer 14

Smoking cessation

Question 15

Side effects of trazadone

Answer 15

Drowsiness, sexual disfunction, dizziness with minimal anticholinergic effects

Question 16

What is trazadone generally used for?

Answer 16

Insomnia

Question 17

What is mirtazepine?

Answer 17

Defined as a noradrenergic and specific serotonergic antidepressant (NaSSA)

Question 18

Side effects of mirtazepine

Answer 18

Increased appetite
Drowsiness

May be helpful for those with insomnia

Question 19

What is the MOA of lithium?

Answer 19

Unknown

Question 20

What is lithium used for?

Answer 20

Bipolar disorder

Question 21

Side effects of lithium

Answer 21

Tremor
Sedation
Weight gain
Acne
Heart block
Polyuria
Decreased cognition
Incoordination

Question 22

What can increase the risk of lithium toxicity?

Answer 22

Dehydration
High salt diet,
Certain medications (NSAIDs, thiazides, ACE inhibitors)

Question 23

How does lithium toxicity present?

Answer 23

AMS
Seizures
Acute renal failure

Question 24

Which meds are the typical antipsychotics?

Answer 24

Haloperidol
Thioridazine
Fluphenazine
Chlorpromazine

Question 25

Which meds are the atypical antipsychotics?

Answer 25

Olanzapine Clozapine Quetiapine Risperidone Ziprasidone

Question 26

All antipsychotics have a small increased risk of death when used in patients with ___.​

Answer 26

Dementia

Question 27

MOA of typical antipsychotics

Answer 27

Antagonism of the D2 receptor in the mesolimbic pathway ## Footnote Also acts on a1 adrenergic, cholinergic and histaminergic receptors

Question 28

Side effects of typical antipsychotics

Answer 28

Hypotension, dizziness and drowsiness, dry mouth, constipation, and weight gain Higher risk of developing extrapyramidal symptoms