Psychosis - Schizophrenia Flashcards

(84 cards)

1
Q

What are 1st line antipsychotics for schizophrenia?

A

TYPICAL antipsychotics

Aripiprazole + quetiapine

Then consider stronger + more S/E:

Olanzapine + Risperidone

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2
Q

How to treat schizoaffective disorder

A

Antipsychotic e.g. resperidone

AND

Mood stabiliser e.g. Lithium

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3
Q

Delusional disorder management?

A

Admission if risk

Limited evidence for use of medications

consider CBT and social skills training

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4
Q

A patients haloperidol is stopped and clozapine is started, what is the next line of investigation?

A

FULL BLOOD COUNT

Clozapine is used when all else has failed, it is atypical but can cause neutropenia and agranulocytosis

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5
Q

What is alogia?

A

Poverty of speech

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6
Q

What is flight of ideas?

A

leaps from one topic to another but with links between them.

Speech at a fast rate. More commonly associated with mania.

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7
Q

How to treat tardive dyskinesia?

occurs in taking typical antipsych prolonged period of time

A

Tetrabenazine

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8
Q

What happens when antipsychotics act on the Tuberoinfundibular pathway?

A

Hyperprolactinaemia

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9
Q

Which antipsychotic can cause antimuscuranic S/E

(dry mouth, blurred vision, urinary retention)

A

Atypical:

Aripiprazole
Quetiapine

Risperidone
Olanzapine

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10
Q

What is parkinsonism? (caused by typical Antipsychotics) + treatment

A

Parkinsonism
tremor, rigid, slow movement

  • switch to lower dose of antipsychotic
  • give procyclidine (anticholinergic)

‘give procyclidine to make a pro cyclist’

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11
Q

Clozapine is a atypical antipsychotic - what are the S/E?

A

SCAM:

Seizure (+hypersalivtion -> tx hyoscine)
Constipation
Agranulocytosis
Myocarditis

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12
Q

Delusional disorder subtype:

  • Capgras?
A

Belief that a familiar person has been replaced by an exact double imposter

’ thats cap ‘

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13
Q

What is Tardive dyskinesia (caused by typical Antipsychotics) + treatment

A

epetetive, involuntary movements such as grimacing, tongue protrusion or rapid blinking.

Develop after years of antipsychotic use.

Tx: switch medication, tetrabenazine.

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14
Q

Clozapine and smoking?

A

Smoking cessation can cause a rise in clozapine blood levels actually

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15
Q

The mesocortical pathway is relevant to the physiology of?

A

Cognition and executive function
Emotions and affect

  • hypofunction of this dopamine pathway might cause the negative symptoms of schizophrenia
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16
Q

What does the mesolimbic dopamine pathway do physologically?

A

This dopamine pathway regulatives incentive, motivation, reinforcement and fear

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17
Q

What is 2nd line medication for schiziphrenia if 1st line atypical didnt work?

A

Typical:

Haloperidol
Chlorpromazine

= extrapyrdamidal side-effects and hyperproloactinaemia

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18
Q

Which antipsychotics effect QTc the most?

A

Quetiapine (atypical)

Haloperidol (typ)
Chlorpromazine (typ)

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19
Q

Treatment for akathisia - Severe restlessness (Caused by typical antipsychotic)

A

Propranolol BDZ

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20
Q

What is Echolalia

A

repetition of someone else’s speech, including the question that was asked.

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21
Q

What are first rank symptoms?

A

specifically indicative of the disorder.

thought disorders (insertion, withdrawal, broadcasting)

passivity phenomena (being controlled by external influence)

delusional perceptions

auditory hallucinations (thought echo, third person voices, narration).

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22
Q

Which typical antispychotics are available and how do they work?

A

Dopamine D2 receptor antagonists - block dopaminergic transmission in the mesolimbic pathway

However they also have extrapyramidal S/E and hyperprolactinaemia

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23
Q

What is neuroleptic malignant syndrome? (CRANK)

A

After treatment with dopamine antagonists e.g. TYPICAL antipsych:
CRANK

C - confusion
R - rhabdomyolysis
A - autonomic instability
N - nephrotoxicity
K - hyperKalaemia

hypothermia, confusion, autonomic instability (sweating, tachycardia, hypertension), raised creatine kinase

Can lead to life threatening:
Rhabdomyolysis
AKI
Hyperkalaemia

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24
Q

What does the mesolimbic dopamine pathway do physologically?

A

This dopamine pathway regulatives incentive, motivation, reinforcement and fear

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25
What is neologisms?
new word formations (may combine two words). Sign of mania.
26
What is Perseveration
repetition of ideas or words despite an attempt to change the topic.
27
Specific side effects : Risperidone? (Atypical antipsychotic)
Hyperprolactinaemia | altho this is usually more common in typical antipsychotics
28
How to treat treatment resistant schizophrenia? (Which requires 3rd line meds)
Clozapine ‘Treatment-Resistant’ → failure to respond to two antipsychotics (at least one atypical), given at a therapeutic dose for at least six weeks.
29
Brief psychotic disorder?
lasts <1 month and subsequent return to baseline functioning.
30
What is posturing and when is this seen?
Catatonia (catatonic schizophrenia)
31
What is neuroleptic malignant syndrome treatment?
Management inovles stopping the offending drug, and supportive treatment (external cooling devices + rehydration with IV fluids). Dantrolene may also be used. (muscle relaxant)
32
What do antipsychotics do when acting on the mesolimbic pathway?
Improve symptoms (often for schizophrenia)
33
What is the role of the tuberofundibular pathway?
This dopamine pathway tonically inhibits prolactin release
34
What are grandiose delusions?
Unfounded or inaccurate beliefs that one has special powers, wealth, mission, or identity
35
What is Akathisia? (caused by typical Antipsychotics) + treatment
Severe restlessness treat: switch or lower dose of antipsychotic Give propranolol BDZ
36
What are the subtypes of schizophrenia? (4)
Paranoid (most common) Catatonic Hebephrenic Simple
37
What is it called when a patient senses sensations being imposed on them?
Somatic passivity
38
What may be seen on MRI (imaging) for schizophrenia?
Hypoactivity in the prefrontal cortex
39
What do you give for the first episode of psychosis acutely?
Oral lorazepam + midazolam (for sedation) Need to Early intervention in psychosis team start on atypical antipsychotics e.g. aripiprazol / quetiapine (start low go slow)
40
What are word salads
completely incoherent speech where real words are strung together into nonsense sentences.
41
What is Acute dystonia? (caused by typical Antipsychotics) + treatment
Sustained muscle contraction (eg. torticollis - deviation of neck, oculogyric crisis - upward deviation of eye and clenched jaw). Treat with procyclidine (anticholinergic)
42
Specific side effects : Of Quetiapine? (Atypical antipsychotic)
QT prolongation - do ECG prior to starting
43
What is avolition?
Poor motivation the inability to initiate or engage in goal-directed behaviors, as they cannot anticipate pleasurable experiences
44
Which typical antispychotics are available
Dopamine D2 receptor antagonists Haloperidol Chlorpromazine
45
Antipsychotics in the elderly cause an increased risk of?
STROKE + VTE
46
What is the physiological role of nigrostrial dopamine pathway?
Effects are brought around by D2 antagonists This dopamine system contains 80% of the brains dopamine. Involved with motor planning and purposeful movement
47
What is 'knights move'
unexpected and illogical leaps from one idea to another. More commonly associated with schizophrenia.
48
Which atypical antipsychotic is the best for negative symptoms
clozapine
49
What are some indications in a schizophrenia case which indicates poor prognosis?
- Strong family history - gradual onset - prodomal phase of social withdrawal - lack of obvious precipitant - low IQ
50
What is tangentiality?
wandering from a topic without returning to it, usually with loosely discernible links.
51
Auditory hallucinations: Thought Echo 3rd Person Voices Running Commentary Command
patient’s thoughts appear to be projected out loud people talking about you in 3rd person hear a running commentary out loud voices in 2nd person telling patient to do something
52
Delusional disorder subtype: Cotard syndrome?
Nihilistic delusion: o : Patient denies self-existence, is putrefying, or has lost blood or internal organs.
53
Which team is required for first episode psychosis or non urgent emergency?
Early intervention psychosis team
54
What is aripiprazole?
atypical antipsychotic
55
Delusional disorder subtype: Fregoli
o Belief that a complete stranger is actually a familiar person already known to one.
56
Family history, genetics and schizophrenia?
is the biggest risk factor for schizophrenia monozygotic twin has schizophrenia = {{c2::50%}} parent has schizophrenia = {{c3::10-15%}} sibling has schizophrenia = {{c4::10%}} no relatives with schizophrenia = {{c5::1%}}
57
What is circumstantiality?
inability to answer a question without giving excessive uneccessary detail (but person does eventually return to original point).
58
What is 1st line psychological intervention for schizophrenia?
CBT
59
What is seen in Hebephrenic schizophrenia?
Usually 15-25 years old. Disorganised speech (neoligisms, knight’s move thinking) and mood. I Inappropriate effect (eg. lauging at something sad).
60
Typical antipsychotics can cause extrapyramidal side effects such as? (PATA)
Parkinsonism Akathisia Tardive dyskinesia Acute dystonia
61
Delusional disorder subtype: - Erotomanic / De clereambault syndrome
The patient believes that another person is secretly in love with them – often associated with a celebrity/unattainable/not part of the patient’s social circle. Can lead to stalking / assultive behaviour Excessive sexual desire
62
What is delusional disorder?
Delusional disorder is characterised as the presence of one or more delusions of >1 month in a patient who is functionally intact.
63
Differentials for psychosis can be split into organic causes ? Psychotic disorders ? Affective disorders with pyschosis? Postpartum?
rganic causes : dementia, delirum, parkinsons, huntingtons, substance / steroid induced Psychotic disorders : Schizophrenia, acute psychosis, delusional disorder Affective disorders with pyschosis: depression with psychotic symptoms, BPAD/mania with psychotic symptoms Postpartum: Peurperal psychosis
64
What is seen in paranoid schizophrenia?
Paranoid (most common) -> main symptoms are prominent delusions and hallucinations.
65
What differentiates depression with psychosis from schizoaffective disorder?
Schizoaffective: presence of symptoms of schizophrenia (eg. delusions, heallucinations) for at least 1 month alongside features of a mood disorder (ie. mania or depression) [present together during one episode, or within two weeks of each other]. there should be a period of at least 2 weeks where psychosis is observed in the absence of mood symptoms
66
What are clang associations?
ideas are related only by the fact they sound similar or rhyme.
67
Most common S/E for atypical antipsychotic medications
Weight gain
68
What is seen in Simple schizophrenia?
Negative symptoms only
69
What is Knight's move thinking and when is this seen?
Hebephrenic schizophrenia Knight's move thinking (aka Derailment)- patient moves from one idea to another with strage illogical associations between the ideas.
70
Delusional disorder subtype: - Jealous type / orthello syndrome
he patient believes that a spouse or partner is unfaithful and finds ‘evidence’ to support the delusion. o Accuses the spouse - Aggressive, threatening and possibly violent behaviour (homicide and suicide). o Delusion of infidelity.
71
thought insertion
believe some of their thoughts are not their own but have been implanted by someone else}}
72
thought withdrawal
:believe someone else is accessing their thoughts
73
thought broadcasting
believe everyone can hear their thoughts}}
74
Delusional disorder subtype: - Somatic type
The patient believes that there is something wrong with their body. - Undiagnosed disease - Delusional parasitosis - Facitious disorder - Hyperchondriasis
75
What happens when antipsychotics block the nigrostriatal dopamine pathway?
Extrapyramidal symptoms (drug induced movement disorders)
76
which type of antipsychotic has less risk of EPSE and hyperprolactinaemia?
Atypical- duh
77
Delusional disorder subtype: Delusions of infestation / Ekbom syndrome
False belief that one is infested with small but visible organisms Secondary to tactile hallucinations.
78
What is factitious disorder?
A somantic delusion disorder belief
79
Which atypical antipsychotic has the best side effect profile?
Aripiprazole especially for prolactin elevation
80
Delusional disorder subtype: - persecutory type
Preoccupied by a delusion that they are being persecuted, conspired against or potentially harmed.
81
List the 4 dopamine pathways?
Mesolimbic pathway Mesocortical pathway Nigrostriatal Tuberoinfundibular
82
How do MOAs work?
act on a variety of receptors (D2, D3, D4, 5-HT) Can also block serotonin 5 HT2 receptors as well as dopamine receptors
83
What is schizophrenia?
Psychosis (hallucinations, delusions, lack of insight) → ≥1 positive symptoms for >1 month and generally lasting >6 months.
84
What is waxy flexibility and when is this seen?
Catatonia (Catatonic schizophrenia) If one were to move the arm of someone with waxy flexibility, the patient would keep that arm where it had been positioned until moved again as if positioning malleable wax