Psychosis - Schizophrenia Flashcards
(84 cards)
What are 1st line antipsychotics for schizophrenia?
TYPICAL antipsychotics
Aripiprazole + quetiapine
Then consider stronger + more S/E:
Olanzapine + Risperidone
How to treat schizoaffective disorder
Antipsychotic e.g. resperidone
AND
Mood stabiliser e.g. Lithium
Delusional disorder management?
Admission if risk
Limited evidence for use of medications
consider CBT and social skills training
A patients haloperidol is stopped and clozapine is started, what is the next line of investigation?
FULL BLOOD COUNT
Clozapine is used when all else has failed, it is atypical but can cause neutropenia and agranulocytosis
What is alogia?
Poverty of speech
What is flight of ideas?
leaps from one topic to another but with links between them.
Speech at a fast rate. More commonly associated with mania.
How to treat tardive dyskinesia?
occurs in taking typical antipsych prolonged period of time
Tetrabenazine
What happens when antipsychotics act on the Tuberoinfundibular pathway?
Hyperprolactinaemia
Which antipsychotic can cause antimuscuranic S/E
(dry mouth, blurred vision, urinary retention)
Atypical:
Aripiprazole
Quetiapine
Risperidone
Olanzapine
What is parkinsonism? (caused by typical Antipsychotics) + treatment
Parkinsonism
tremor, rigid, slow movement
- switch to lower dose of antipsychotic
- give procyclidine (anticholinergic)
‘give procyclidine to make a pro cyclist’
Clozapine is a atypical antipsychotic - what are the S/E?
SCAM:
Seizure (+hypersalivtion -> tx hyoscine)
Constipation
Agranulocytosis
Myocarditis
Delusional disorder subtype:
- Capgras?
Belief that a familiar person has been replaced by an exact double imposter
’ thats cap ‘
What is Tardive dyskinesia (caused by typical Antipsychotics) + treatment
epetetive, involuntary movements such as grimacing, tongue protrusion or rapid blinking.
Develop after years of antipsychotic use.
Tx: switch medication, tetrabenazine.
Clozapine and smoking?
Smoking cessation can cause a rise in clozapine blood levels actually
The mesocortical pathway is relevant to the physiology of?
Cognition and executive function
Emotions and affect
- hypofunction of this dopamine pathway might cause the negative symptoms of schizophrenia
What does the mesolimbic dopamine pathway do physologically?
This dopamine pathway regulatives incentive, motivation, reinforcement and fear
What is 2nd line medication for schiziphrenia if 1st line atypical didnt work?
Typical:
Haloperidol
Chlorpromazine
= extrapyrdamidal side-effects and hyperproloactinaemia
Which antipsychotics effect QTc the most?
Quetiapine (atypical)
Haloperidol (typ)
Chlorpromazine (typ)
Treatment for akathisia - Severe restlessness (Caused by typical antipsychotic)
Propranolol BDZ
What is Echolalia
repetition of someone else’s speech, including the question that was asked.
What are first rank symptoms?
specifically indicative of the disorder.
thought disorders (insertion, withdrawal, broadcasting)
passivity phenomena (being controlled by external influence)
delusional perceptions
auditory hallucinations (thought echo, third person voices, narration).
Which typical antispychotics are available and how do they work?
Dopamine D2 receptor antagonists - block dopaminergic transmission in the mesolimbic pathway
However they also have extrapyramidal S/E and hyperprolactinaemia
What is neuroleptic malignant syndrome? (CRANK)
After treatment with dopamine antagonists e.g. TYPICAL antipsych:
CRANK
C - confusion
R - rhabdomyolysis
A - autonomic instability
N - nephrotoxicity
K - hyperKalaemia
hypothermia, confusion, autonomic instability (sweating, tachycardia, hypertension), raised creatine kinase
Can lead to life threatening:
Rhabdomyolysis
AKI
Hyperkalaemia
What does the mesolimbic dopamine pathway do physologically?
This dopamine pathway regulatives incentive, motivation, reinforcement and fear