puberty

Question 1

in childhood, levels of GnRH, FSH, LH, and sex steroids are very what

Answer 1

low

Question 2

what is responsible for initiating puberty

Answer 2

hypothalamus

Question 3

what initiates the increase in GnRH production

Answer 3

KISSpeptin, GABA, NMDA

Question 4

why doesn’t menstruation coincide with ovulation

Answer 4

-endometrium thickened by bE2
-not enough E2 to stimulate AVPV and luteinization
-no LH surge = no ovulation = no P4 = endometrium sloughed off

Question 5

what is the purpose of the tanner scale

Answer 5

can compare patient’s secondary sex characteristics with established norms

Question 6

is there a role for genetics in puberty

Answer 6

yes

Question 7

what gene contributes to puberty

Answer 7

CYP3A4: accelerates breakdown of testosterone

Question 8

what happens if you have 2 copies of the high activity allele if you are an ovary-having person

Answer 8

begin puberty earlier

Question 9

what could cause precocious puberty (early)

Answer 9

low testosterone and early KISSpeptin receptors

Question 10

why are they changing the timeframe for precocious puberty for ovary people from 8 to 7

Answer 10

gain more adipose tissue from food we eat

more kisspeptin, more leptin from adipose tissue

Question 11

what is treatment for precocious puberty

Answer 11

GnRH agonists; internalizing receptors of GnRH

Question 12

what are some causes of delayed puberty

Answer 12

hypogonadism, lack of GnRH signaling, anorexia