To penetrate the cumulus oophorus, sperm cells:
have hyaluronidase to break up the extracellular environs of the cells.
To penetrate the zona pellucida, sperm cells…
-Undergo an acrosome reaction
-Have receptors for ZP3
Syncytial trophoblasts:
-have no plasma membrane between them, with communicating cytoplasm
-secrete protease to break down cells of endometrium
One possible reason maternal immune cells do not attack implanting blastocysts is:
syncytial trophoblasts, which surround the blastocyst, largely lack human leukocyte antigens, except for HLA-G