PUD medications

Question 1

PPI adr?

Answer 1

D, HA, B12 deficiency, gastric polyps

**omeprazole is P450 inhibitor

Question 2

H2 blocker moa

Answer 2

reduces acid/pepsin secretion

Question 3

adr of cimetidine?

Answer 3

P450 inhibition, gynecomastia, impotence, dec libido

Question 4

what must you think of w/ H2 blockers?

Answer 4

renal/hepatic dysfunction

Question 5

moa of misoprostol?

Answer 5

Prostoglandin analog  inc bicarb and mucus secretion

• Good for prevention, but not tx of active ulcers
• CI: premenopausal women because it is abortifacent

Question 6

bismuth compounds moa

Answer 6

antibacterial and cytoprotective

Question 7

what are adr of bismuth compounds?

Answer 7

darkening of tongue/stool, constipation

Question 8

what is the moa of sucralfate?

Answer 8

cytoportective, more prophylactic than tx

Question 9

what are some DI of sucralfate?

Answer 9

may reduce H2, PPI, FQ

Question 10

what are causative factors of DU?

Answer 10

increasing damaging: acid, pepsin, H, pyloir

Question 11

what is the incidence of DU?

Answer 11

4x more common; normally benign; MC in duodenal bulb

Question 12

what age do pple normally present with DU?

Answer 12

younger, 30-55 yo

Question 13

what are causative factors of GU?

Answer 13

decrease protective: mucus, bicarb, prostaglandins, NSAIDs

Question 14

incidence of GU?

Answer 14

4% malignant, MC in antrum of stomach

Question 15

age of Gu?

Answer 15

older, 55-70 yo