Pulmonary Pharmacology Flashcards Preview

Cardio Pulm > Pulmonary Pharmacology > Flashcards

Flashcards in Pulmonary Pharmacology Deck (36):
1

4 types of bronchodilators

-sympathomimetics
-sympatholytics
-parasympatholytics
-methylxanthines

2

Bronchial diameter Controlled by:

SNS and PNS

3

Parasympatholytic Drug Endings

-tropium

4

Sympathomimetic Drug Endings

-erol
-enol
-olol

5

Sympathomimetics

-Beta Agonists
-Bronchodilators
-Selective (short/long acting)
-Nonselective

6

SNS releases ____ which bind to _____ which act on ____

-Norepinephrine

-alpha1, alpha2, beta1, beta2 receptors

-Smooth Muscle of Lungs (through cAMP 2nd messenger)

7

LRB's

-leukotriene receptor blocker

(no side effects)

8

-erol
-enol
-olol

-sympathomimetics

9

PNS releases ____ which binds to _____ which act on_____

-Acetylcholine

-nicotinic, muscarinic receptors

-smooth muscle in lungs (through cAMP 2nd Messenger)

10

Methyxanthines

-bronchodilation
-Therapeutic level close to toxic level

11

Methylxanthines work by:

-inhibiting phosphodiesterase to increase cAMP
-antag to adenosine
-inhibit intracellular Ca++ release
-inhibit prostaglandins

(increase diaphragm's ability to contract and resist fatigue)

12

-phylline

-methyxanthines

13

-lukast

LRBs

14

Selective Drug Side Effects
(sympathomimetics)

-nervousness
-headaches
-tremors

15

Corticosteroids on ANS

-enhance Beta2 effect
-inhibit Alpha effect

16

mucolytics

-thin secretions by breaking disulfide bonds of mucus

17

Mechanism of Chromolyn and Nedocromil

-(prophylactic)
-inhibit release of inflammatory mediators (histamines & leukotrienes)

18

Non-selective drug side effects
(sympathomimetics)

-nervousness, headaches, tremors
-Beta: tachycardia, angina, cardiac dysrhythmias
-Alpha: peripheral vasoconstriction

19

Parasympatholytics

-anti-cholinergics
-tropium
-bronchodilation

20

Cholinergic input=

-bronchoconstriction

(cholinergic=acetylcholine on muscarinic/nicotinic rec)

21

SNS Beta2 Receptor

-Bronchodilation
-via cAMP 2nd messenger

22

Stimulation of Muscarinic Receptor-->

-increased guanyl cyclase-->
-convert GTP to GMP-->
-Cyclic GMP cause bronchoconstriction

(cGMP broken down by phosphodiesterase)

23

LRB drug Endings

-lukast

24

SNS Alpha1 Receptor

-bronchoconstriction
-via cAMP/cGMP
-usually in diseased lungs only

25

-tropium

parasympatholytics

26

-asone

-corticosteroids

27

Signs of Methyxanthine Toxicity

-Heart Arrhythmias
-Seizures
-Nausea
-Restlessness
-Irritability
-Confusion

28

Methylxanthine Drug Endings

-phylline

29

Anti-inflammatory drugs

-corticosteroids
-cromolyn & nedocromil
-leukotriene synthesis inhibitors
-leukotriene receptor blockers

30

Corticosteroid Drug Endings

-asone

31

Beta1 receptors are also located in:

-the heart
(increase HR)

32

Alpha1 receptors are also located in:

-Arteries
-(increase vasoconstriction)

33

Side effects of Corticosteroids

-osteoporosis
-muscle wasting
-skin break down
-hyperglycemia
-cataracts

34

Side Effects of Cromolyn & Nedocromil

-irritation of nasal & upper respiratory passages

35

Sympatholytics

-Alpha antagonists-->bronchodilation

36

Corticosteroid Mechanism of Action

-inhibits production of prostaglandins & leukotrienes
-inhibit neutraphils & monocyte migration
-reverse decrease in vascular permeability
-bronchodilation through ANS (increase Beta2 effect, decrease Alpha effect