QFR 5 Flashcards
(62 cards)
●
are excellent antigens because of their:
○
High molecular weight
○
Structural complexity
Protein-based antigens
are inferior antigens because of their
relative simplicity and lack of structural
stability.
Lipids
are poor antigens because of relative
simplicity, molecular flexibility, and their
rapid degradation.
Nucleic acids
the more that your antigens
would
come
from
different
species of certain animals or
plants and they are introduced
to our system, the more that
they are likely to produce an
immune response within our
body
Foreigness
____________ or your own
antigens will not induce an
immune response within your body.
Because
it
will
be
contained
within your body
naturally
Autoantigens
a. the higher resistance an antigen is when
it comes to the different processes
within our body,then there is a chance
that that antigen could become an
immunogen.
b. But the higher the chances that your
antigen would be easily degraded, then
it is more likely that it will not induce an
immune response.
Degradability
a. the higher the molecular weight, the
better the molecule will function as an
antigen.
Molecular weight
a. If a molecule is an effective antigen,
__________________ is mandatory.
b. If a structure is unstable,the molecule
will be a poor antigen.
Structural stability
________________ are poor antigens
because they would not interact with our
immune system
Totally inert molecules
a. the more complex an antigen, the
greater is its effectiveness.
b. Proteins are better antigens compared
to the polymers of carbohydrates, your
polysaccharides, and even the different
polymers of lipids and nucleic acids.
Complexity
substances that are
presented into our
body, which is not
typically there.
Antigen
composed of different
biomolecules like
proteins,
polysaccharides,
lipids, and even
nucleic acids
Antigen
antigens that could
induce an immune
reaction within our
body mostly made up of
proteins and even
polysaccharides
Immunogen
substances that are non-immunogenic
but it can react with the products of a
specific immune response, even with no
antibody formation.
-
low molecular weight of less than
10,000 daltons that could never induce
an
immune
response
when
administered on their own.
-
But if it is coupled to a carrier molecule,
there is a higher chance that these
happens could be considered as an
immunogen.
-
property of antigenicity
Haptens
are derived from your own body or they
are derived from the same individua
Autoantigens
are antigens that are derived from a
different individual of the same species
Alloantigens
these are
antigens that are derived from different
species.
Xenogenic / heteroantigens
antigens that are found in unrelated
plants and animals, which can actually
cross-react with an antibody of another
that had induced the said immune
response or the induction of the
antibody production.
Heterophile antigens
These antigens are not seen by
the developing immune system
and
will
not
induce
self-tolerance
Sequestered
these are antigens that are
characteristic of one tissue or
cell only.
Tissue-specific antigens
do not directly stimulate the
production of Ab without the
help of T-cells
T-dependent
can directly stimulate without
T-cells
T-independent
able
to
elicit
T-lymphocyte
responses
by
circumventing
normal antigen processing and
presentation functions.
Super antigens
Proteins that have the ability to bind to an
invariant region of the class II MHC on an APC
and to crosslink this receptor to a T-cell through
binding to the variable region of the beta-chain
of the T-cell antigen receptor
Super antigens
