ANTIGEN

Question 1

Macromolecules that is capable triggering an adaptive
immune response by inducing formation of antibodies or
sensitized T- cells of an immunocompetent host

Answer 1

Immunogen

Question 2

Can evoke an immune response

Answer 2

Immunigen

Question 3

• Substance that reacts with antibody or sensitized T cells but
may not evoke an immune response
• Can only bind sensitized T cells or antibody, not capable of sensitizing T and B cells (no reaction)

Answer 3

Antigen

Question 4

Ability to induce a humoral and/or cell-mediated immune
response

Answer 4

Immunoginecity

Question 5

Ability to combine specifically with the final products of the
immune response

Answer 5

Antigenicity

Question 6

What are the final products of antigenicity?

Answer 6

secreted antibodies and/or surface
receptors on T-cell

Question 7

What are the factors influencing the immune response?

Answer 7

Size
Foreignness
Chemical composition and molecular complexity
Adjuvants
Route, Dose, Timing

Question 8

This is the ability of the person to mount an immune response

Answer 8

Immunocompetent

Question 9

Coupled with a certain receptor

Answer 9

Antigenicity

Question 10

their immune system is not completely developed

Answer 10

Neonates

Question 11

Pediatricians monitor closely neonates that get sick from ___________ old

Answer 11

0-3
months

Question 12

the immune system won’t work well if the body
does not receive the enough nutrition that it needs (especially
here in the Philippines and children

Answer 12

Malnutrition

Question 13

What are the routes of inoculation?

Answer 13

Intravenous
Intradermal
Subcutaneous
Oral contact

Question 14

This is inoculated into the vein.The fastest route of entry of an immunogen because it will
enter directly into the bloodstream

Answer 14

Intravenous

Question 15

This is inoculated into the skin.

Answer 15

Intradermal

Question 16

This is inoculated beneath the skin / tissue.

Answer 16

Subcutaneous

Question 17

What is the primary organ to fight off the immunogen in an intravenous route?

Answer 17

Spleen

Question 18

What is the example of subcutaneous?

Answer 18

Local lymph nodes

Question 19

Linked to MHC (Major Histocompatibility Complex) and to
receptors generated during T and B lymphocyte development

Answer 19

Genetic capacity

Question 20

system of genes that code for cell surface molecules that
play an important role in antigen recognition

Answer 20

MHC (Major Histocompatibility Complex)

Question 21

What is the MW of the best immunogens?

Answer 21

100,000 Daltons

Question 22

This route of inoculation has a stronger stimuli than subcutaneous.

Answer 22

Intradermal

Question 23

What is the rule of thumb of macromolecular size?

Answer 23

the greater the molecular weight, the more
potent the molecule to induce an immune response

Question 24

Lymphocyte capable of reacting with self- antigen is normally eliminated. Will determine if the antigen foreign or self
. Should be eliminated because it is a self-antigen

Answer 24

Foreignness

Question 25

Which are the best immunogens?

Answer 25

Proteins

Question 26

Which is the 2nd best immunogen?

Answer 26

Polysaccharides

Question 27

This is the least immunogenic and must be attached to a carrier particle before being an immunogen.

Answer 27

Lipid and nucleic acids

Question 28

These are antigenic determinants and are molecular shapes or configurations that are recognized by B or T cells

Answer 28

Epitopes

Question 29

Immunologically active regions of an immunogen that bind to antigen-specific membrane receptors on lymphocytes or to secreted antibodies

Answer 29

Epitopes

Question 30

amino acids following one another on a single chain

Answer 30

SEQUENTIAL OR LINEAR EPITOPES

Question 31

results from the folding of one chain or multiple chains, bringing certain amino acids from different segments of a linear sequence or sequences into close proximity with each other so they can be recognized together

Answer 31

CONFORMATIONAL OR DISCONTINUOUS EPITOPE

Question 32

Small organic compound that are antigenic but not immunogenic

Answer 32

Haptens

Question 33

reactions that we observe in the serology laboratory indicating an antigen-antibody reaction

Answer 33

Precipitation/ agglutination

Question 34

What should a hapten do to become a complete antigen/immunogen?

Answer 34

they should be coupled to a carrier

Question 35

Who wrote the specificity of the serological reaction?

Answer 35

Karl Landsteiner

Question 36

He discovered that antibodies not only recognize chemical features such as polarity, hydrophobicity, and ionic charge, but the overall three-dimensional configuration is also important. Immunized rabbits with haptens attached to a carrier molecule.

Answer 36

Karl Landsteiner

Question 37

• Substances that are administered with an immunogen that increase the immune response in order to provide immunity to a particular disease • Used to make vaccine

Answer 37

Adjuvants

Question 38

This is an example of Adjuvants used to complex with the immunogen to increase its size and to prevent a rapid escape from the tissues

Answer 38

Aluminum salts

Question 39

• Antigens that belong to the host • Do not evoke an immune response under normal circumstances • The only problem that will occur is that if the lymphocytes don’t have the capability of discriminating self from non-self

Answer 39

Autoantigens

Question 40

• From other members of the host’s species • Human to human • Capable of eliciting an immune response

Answer 40

Alloantigens

Question 41

From other species such as other animals, plants or microorganisms

Answer 41

Heteroantigens

Question 42

• hetereoantigens that exist in unrelated plants or animals • Either identical or closely related in structure so that antibody to one will cross- react with antigen of the other

Answer 42

Heterophile antigens