Quiz 2

Question 1

What is the systemic immune system made of?

Answer 1

Bone marrow
Spleen
Lymph nodes

Question 2

Pathogen enters —> DC takes up antigen —> DC migrates to nearest lymph node —> DC presents to T cell —> T cell activates and goes into circulation

What is the inductive site?

Answer 2

Lymph nodes

Question 3

Pathogen enters —> DC takes up antigen —> DC migrates to nearest lymph node —> DC presents to T cell —> T cell activates and goes into circulation

What is the effector site?

Answer 3

Infected tissue

Question 4

Was the systemic or mucosal immune system discovered first?

Answer 4

Systemic

Question 5

What is special about mucosal inductive sites?

Answer 5

They lack afferent lymphatics because they sample antigens directly from mucosal surface

Question 6

What are the 4 types of MALT?

Answer 6

GALT (gut)
NALT (nasal)
BALT (bronchus)
TALT (tear-duct)

Question 7

What is the GALT made up of?

Answer 7

Peyer’s patch
Isolated lymphoid follicles (ILF)
Appendix

Question 8

What MALT is MLN (mesentric lymph nodes) associated with?

Answer 8

GALT

Question 9

What are MLN (mesentric lymph nodes)?

Answer 9

Draining lymph nods of GALT

Question 10

What is the NALT made up of?

Answer 10

Waldeyer’s ring (adenoid and palatine tonsils)

Question 11

What are CLN (cervical lymph nodes)?

Answer 11

Draining lymph nodes of NALT

Question 12

What MALT is typically not found in adults?

Answer 12

BALT

Question 13

What are effective sites?

Answer 13

Where effector cells perform thier action

Question 14

What’s are the 3 effector sites of the mucosal immune system?

Answer 14

Lamina propria
Surface epithelium
Stroma of exocrine glands

Question 15

What are some examples of innate immune cells?

Answer 15

macrophages
DC
Granulocytes

Question 16

What are some examples of adaptive immune cells?

Answer 16

All B and T cells
Plasma cells

Question 17

Where are most innate immune cells located in mucosal immunity?

Answer 17

Lamina propria

Question 18

What are some of the cell types in Peyer’s patch?

Answer 18

Macrophages
DC
Naive T cells
Naive B cells

Question 19

In systemic immunity, __________ act as the cellular messengers by delivering degraded pathogens to lymphoid organs

Answer 19

Dendritic cells

Question 20

Which of the following is most likely to be found in the inductive compartment of the GALT?

Naive T cells
Effector CD4+ T cells
Eosinophils
Plasma cells
Innate lymphoid cells

Answer 20

Naive CD4+ T cells

Question 21

What kinds of cells are found in inductive sites?

Answer 21

APCs
Naive B and T cells

Question 22

What does the NALT drain into?

Answer 22

Cervical lymph nodes

Question 23

What are the 2 primary lymphoid tissues?

Answer 23

Thymus
Bone marrow

Question 24

What are primary lymphoid tissues?

Answer 24

Site of lymphocyte development

Question 25

What are the 3 secondary lymphoid tissues?

Answer 25

Spleen Lymph nodes MALT (Peyer’s patch, ILT, spleen)

Question 26

What are secondary lymphoid tissues?

Answer 26

Induction of adaptive immune response

Question 27

What allows enter of fluids and lymphocytes unto lymph nodes?

Answer 27

Lymphatic capillaries (afferent vessel)

Question 28

When fluid/lyphocytes enter the lymph nodes via afferent vessels where does it go next?

Answer 28

Outer cortex (contains germinal centers)

Question 29

Where do DCs go to present to T cells in the lymph nodes?

Answer 29

Paracritical area

Question 30

How do lymphocytes leave the lymph nodes?

Answer 30

Efferent vessels

Question 31

How do lymphocytes enter the Peyer’s patch?

Answer 31

Across endothelial venues on M cells (no afferent vessels)

Question 32

How do lymphocytes leave the Peyer’s patch?

Answer 32

Efferent vessels

Question 33

T/F lymph nodes and Peyer’s patch both contain DCs that present antigens to T cells in T cell areas

Answer 33

True

Question 34

T/F lymph nodes and Peyer’s patch both have B cell follicles where T cells can active naive B cells

Answer 34

True

Question 35

T/F lymph nodes and Peyer’s patch both have germinal centers that give rise to plasma cells

Answer 35

True

Question 36

T/F lymph nodes and Peyer’s patch both allow naive lymphocytes in via high endothelial venules from circulation

Answer 36

True

Question 37

T/F lymph nodes and Peyer’s patch both allow activated lymphocytes to leave via efferent lymphatics

Answer 37

True

Question 38

T/F lymph nodes and Peyer’s patch both have afferent lymphatics

Answer 38

False (only lymph nodes have afferent)

Question 39

T/F lymph nodes and Peyer’s patch both have efferent lymphatics

Answer 39

True

Question 40

T/F lymph nodes and Peyer’s patch both sample antigens directly from mucosal surface

Answer 40

False Peyer’s patch only does this

Question 41

Does vascular diameter increase or decrease in inflammatory response and why?

Answer 41

Increase = more blood flow

Question 42

Does permeability increase or decrease in the inflammatory response?

Answer 42

Increase

Question 43

Why does adhesion receptors increase expression on endothelial cells during inflammatory response?

Answer 43

Tells lymphocytes where to go

Question 44

What does clotting increase during the inflammatory response?

Answer 44

Stop spread of infection

Question 45

What 2 things cause tissue damage during inflammatory response?

Answer 45

Fluid leaking Influx of immune cells

Question 46

Systemic immunity inflammatory response is _________ while mucosal immunity inflammatory response is _________ to invading microbes

Answer 46

Reactionary Proactive

Question 47

Why does the mucosal immune system use a proactive response to invading microbes?

Answer 47

Constant exposure to microbes

Question 48

What is the most important thing to maintain in mucosal immunity?

Answer 48

Barrier integrity

Question 49

Why is it important to maintain the barrier integrity of the mucosal immune system?

Answer 49

Fluid leakage between two different compartments can cause complications and tissue damage

Question 50

What mechanisms does the mucosal membrane use in the proactive approach?

Answer 50

Thick mucus and IgA to prevent microbes from ever reaching the epithelium

Question 51

______ are important in preventing epithelial damage because they deliver antigens past the epithelial layer to Peyer’s patch

Answer 51

M cells