Quiz 5

Question 1

The gut immune system doesn’t respond with inflammation but antigen-specific _____________

Answer 1

tolerance

Question 2

What cell aid in tolerance?

Answer 2

Tregs

Question 3

What are the 3 non-inflamamtory/tolerant cytokines that direct DCs?

Answer 3

retinoid acid
TSLP
TGF-B

Question 4

Lymphocytes are primed in _________________ of the mucosal tissue

Answer 4

inductive compartments

Question 4

What are the inductive compartments of the gut?

Answer 4

peyer’s patch
ILF
mesenteric lymph nodes

Question 5

What chemokine recruits naive T cells to the inductive compartments?

Answer 5

CCR7

Question 6

What does CCR7 on lymphocytes recognize?

Answer 6

CCL21

Question 7

What highly expressed CCL21?

Answer 7

HEV on inductive sites

Question 8

What makes entering the MALT v. peripheral lymph nodes is what?

Answer 8

adhesion receptors

Question 9

L-PAM-1 expressed by T cells that recognizes ___________ expressed on endothelium mucosal

Answer 9

MAdCAM-1

Question 10

Can DCs express CCR7 like T cells?

Answer 10

yes

Question 11

Effector T cells squeeze through inflamed endothelial cells. What causes the inflamamtion?

Answer 11

IL-1B

Question 12

What controls the exit of activated effector T cells from T cell zone?

Answer 12

S1P gradient

Question 13

Is S1PR highly expressed on naive or effector T cells?

Answer 13

effector

Question 14

What does S1PR allow T cells to do?

Answer 14

see the S1P gradient and leave the lymphatics

Question 15

What expresses S1P?

Answer 15

endothelial cells of lymph nodes

Question 16

What creates the graident of S1P?

Answer 16

stromal cells that produce S1P lyase

Question 17

Where is the S1P gradient to strongest and weakest?

Answer 17

strong: efferent vessels
weak: T cell zone

Question 18

If T cells are not activated by thier antigen in the T cell zone they upregulate _______ on them

Answer 18

CD69

Question 19

What does CD69 do when highly expressed on T cells?

Answer 19

helps sequester and internalize S1PR, keeping T cell inside the lymph nodes
* cannot see S1P gradient anymore

Question 20

Activated effector T cells have what 2 fates?

Answer 20

1. return to lamina propria
2. migrate to intraepithelial compartment

** both rely on chemokines

Question 21

Small intestines express CCL___ which is recognized by CCR__ on T cells

Answer 21

CCL25
CCR9

Question 22

Large intestines express CCL___ which is recognized by CCR__ and GPR___ on T cells

Answer 22

CCL 28
CCR10 and GPR15

Question 23

Lungs/skin express CCL___ which is recognized by CCR__ on T cells

Answer 23

CCL17
CCR4

Question 24

TFH cells up regulate _______ which allows them to leave T cell zone and migrate to B cell follicles

Answer 24

CXCR5

Question 25

_______ is produced by stromal cells in the B cell follicle and attracts T cells

Answer 25

CXCL13

Question 26

CD103 interacts with ______________ to aid in intraepithelial lymphocyte trafficking

Answer 26

E-cadherins

Question 27

What does E-cadherins do?

Answer 27

expressed below adherens junctions on intestinal epithelial cells to allow intraepithelial lymphocytes to reside between epithelial cells