Quiz 4 - Abdominal Embryology Flashcards Preview

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Flashcards in Quiz 4 - Abdominal Embryology Deck (67):
1

during lateral and longitudinal folding, the endoderm is incorporated into the embryo as the _____

gut tube

2

the gut tube will form...

epithelial lining of the gut and its associated organs

3

once the gut tube is incorporated into the body of the embryo, it can be subdivided into 3 regions...

1. foregut: cranial blind-ended portion that is capped by oropharyngeal membrane
2. midgut: portion that remains temporarily connected to the yolk sac thru the vitelline duct
3. hindgut: caudal blind-ended portion that is capped by the cloacal membrane.

4

allantois

-a small diverticulum of the hindgut that extends into the connecting stalk

5

gut tube is surrounded by the ________

visceral layer of lateral plate mesoderm, which will form the smooth muscle, connective tissue, and visceral peritoneum of the gut and its associated organs

6

as the gut tube is being incorporated into the body of the embryo, it moves away from the ____ body wall and becomes "suspended" into the intraembryonic coelem

dorsal

7

initially, the gut tube is suspended from the dorsal body wall by a ______

mesentary; a mesentary is a double layer of visceral peritoneum that connects an organ to the body wall. Vessels and nerves travel to the gut tube between these layers of visceral peritoneum.

8

dorsal mesentary

-remains in the regions of the abdominal portion of the foregut, midgut, and hindgut
-regions of the dorsal mesentary are named according to the organs they connect to the posterior body wall

9

ventral mesentary

-develops in the region of the abdominal portion of the foregut as a caudal downgrowth from the septum transversum

10

what does the ventral mesentery form?

-falciform ligament (formed by the division of the ventral mesentery by the growing liver)
-lesser omentum

11

organs that are suspended in the abdominal cavity by a mesentery are referred to clinically as _____

intraperitoneal

12

organs that lie against the posterior body wall and are covered by peritoneum only on their anterior surface are considered _____

retroperitoneal

13

primarily retroperitoneal

-an organ that is never suspended by a mesentery

14

secondarily retroperitoneal

-an organ that is initially suspended by a mesentery, but is pushed against the body wall during development
-visceral and parietal layers of the peritoneum meet, fuse, and be reabsorbed
-the organs are now only covered by peritoneum on their anterior surface

15

which structures/organs are primarily retroperitoneal?

-aorta
-iliac arteries
-IVC
adrenal glands
-kidneys
-ureter
-rectum (technically SUBperitoneal)

16

which structures/organs are secondarily retroperitoneal?

-duodenum
-pancreas
-ascending colon
-descending colon

17

which structures/organs are intraperitoneal?

-liver & gallbladder
-distal esophagus
-stomach
-proximal duodenum
-small intestine
-cecum
-transverse colon
-sigmoid colon
-spleen

18

general features of gut development

-MOST organs develop as outgrowths of the gut tube
-gut tube rotations force some organs to change orientation
-each region of the gut tube is associated with particular vessels and nerves

19

blood supply of gut tube

3 major branches (celiac trunk, superior mesenteric artery, inferior mesenteric artery) of the abdominal aorta supply the gut tube. In general, an organ derived from a particular region of the gut tube will be supplied by the artery that was associated with it in the embryo.

20

celiac trunk supplies ___

embryonic foregut

21

superior mesenteric artery (SMA) supplies ___

embryonic midgut

22

inferior mesenteric artery (IMA) supplies ___

embryonic hindgut

23

which nerve supplies embryonic foregut?

Sympathetic: greater splanchnic nerve (T5-T9) via celiac ganglion

Parasympathetic: vagus nerve (CN X)

24

which nerve supplies embryonic midgut?

Sympathetic: lesser and least splanchnic nerves (T10-T12) via superior mesenteric ganglion

Parasympathetic: vagus nerve (CN X)

25

which nerve supplies embryonic hindgut?

Sympathetic: lumbar splanchnic nerves (L1-L2) via inferior mesenteric ganglion

Parasympathetic: pelvic splanchnic nerves (S2-S4)

26

derivatives of the foregut

-pharynx and derivatives
-trachea, bronchi, lungs (lower resp system)
-esophagus
-stomach
-proximal 1/3 of duodenum
-liver & gallbladder
-pancreas

27

how does the stomach form?

-as an expansion of the caudal portion of the foregut
-the dorsal border of the stomach grows faster than the ventral border, creating the greater curvature of the stomach
-the stomach rotates 90* clockwise around its longitudinal (AP) axis, moving the ventral border (lesser curvature) to the right, and the dorsal border (greater curvature) to the left. Rotation also pulls fundus left & inferior, and pylorus right & superior.

28

what produces the spaces of the peritoneal cavity?

-rotation of the stomach and development of the greater and lesser omenta

29

from where does the spleen develop?

-mesoderm in the dorsal mesentery in the stomach
-swings to the left with the rotation of the stomach

30

what divides the ventral mesentary into the falciform ligament and the lesser omentum?

-the developing liver

31

what divides the dorsal mesentery of the stomach (dorsal mesogastrium) into the splenorenal ligament and the gastrosplenic ligament?

-the developing spleen

32

lesser sac (omental bursa)

-a portion of the peritoneal cavity that is "walled off" posterior to the stomach after the rotation of the stomach and the development of the omenta.

(the remaining peritoneal cavity is the greater sac)

33

how do the greater and lesser sacs communicate?

-thru a small opening near the hilum of the liver called the epiploic foramen

34

greater omentum

-the portion of the dorsal mesentery that "hangs down" from the greater curvature of the stomach following rotation

35

lesser omentum

-formerly a part of the ventral mesentery, but after rotation extends between the stomach/1st part of the duodenum and the developing liver

36

where does the dorsal mesentery hang from after rotation of the stomach?

-from the greater curvature of the stomach, where it becomes enlarged to form the greater omentum

37

initially, the lesser sac is continuous with ____

-the space between the layers of the greater omentum (it's like a pouch within a pouch kind of)
-but eventually, the two layers of the greater omentum fuse, leaving 4 total layers of peritoneum and limiting the inferior extent of the lesser sac.
-the mesentery of the transverse colon also fuses with a portion of the greater omentum

38

development of duodenum

-also due to rotation of stomach
-proximal (1st) part of duodenum develops from the terminal portion of the foregut
-the foregut ends just caudal to the origin of the common bile duct at the apex of the duodenal loop
-the rotations of the stomach pull the duodenum into a C-shape around the head of the developing pancreas
-the duodenum becomes pressed against the dorsal body wall, becoming secondarily retroperitoneal

39

the pancreas forms from 2 different outgrowths of the foregut. what are they?

-ventral pancreatic bud (in the ventral mesentery, which is an outgrowth of the bile duct)
-dorsal pancreatic bud (in the dorsal mesentery, which is an outgrowth of the foregut)
-with rotation of the stomach and duodenum, the ventral bud rotates dorsally behind the duodenum and fuses to the dorsal bud. The ducts of the pancreatic buds also fuse, normally forming one pancreatic duct which opens into the duodenum at the major duodenal papilla
-pressed against the dorsal body wall, so secondarily retroperitoneal

40

what does the ventral pancreatic bud give rise to?

-uncinate processes of the pancreas

41

what does the dorsal pancreatic bud give rise to?

-tail of the pancreas

42

formation of liver and gallbladder

-form as outgrowths of the ventral foregut in the region of the developing duodenum

43

liver bud

=hepatic diverticulum
-arises cranial to the developing pancreas
-grows into the septum transversum
-differentiates into the liver parenchyma (liver cells)
-as the liver bud grows, its connection to the foregut narrows, forming the bile duct

44

from what are the connective tissue, hematopoietic cells, and Kupffer cells of the liver derived?

-mesoderm of the septum transversum

45

gallbladder forms...

...as an outgrowth of the bile duct

46

what does the growing liver divide the ventral mesentery into?

-hepatogastric ligament
-hepatoduodenal ligament
-falciform ligament

47

annular pancreas (AP)

-rare congenital abnormality; usu non-symptomatic
-results in a ring of pancreatic tissue that can partially or completely constrict the descending duodenum
-if symptoms do occur, they can do so at any age
-typical symptoms: abdominal pain, nausea, lack of appetite, vomiting
-surgical intervention = treatment

48

derivatives of the midgut

-small intestines (EXCEPT for 1st and 2nd parts of duodenum = foregut)
-cecum & appendix
-ascending colon
-proximal 2/3 of transverse colon

49

when does the midgut elongate?

-5th week, forming a U-shaped midgut loop

50

cranial limb of the midgut loop

-will form most of the small intestine

51

caudal limb of the midgut loop

-will form most of the large intestine

52

how is the apex of the midgut loop connected to the yolk sac?

-by the vitelline duct, which lies within the umbilical cord

53

what happens in the 6th week, when the midgut loops grows faster than the abdominal cavity?

-the midgut loop herniates into the abdominal cord
-as herniation occurs, the loop undergoes a 90* CCW rotation around the superior mesenteric artery
-this rotation brings the cranial limb (small intestine) to the right side of the body, and the caudal limb (large intestine) to the left side of the body
-the loop continues to elongate and the caudal limb (large intestine) develops an enlarged cecal bud (future cecum)

54

what happens in re: to the midgut by the 11th week, when the abdominal cavity has increased in size?

-the cavity can reincorporate the intestines
-as the loop is retracting, it undergoes an additional 180* CCW rotation
-the cranial limb (small intestine) retracts first, and as it does so, it becomes located more towards the left side of the abdominal cavity.
-the caudal limb (large intestine) becomes situated to the right

55

initially the cecum and the ascending colon rest under the liver. how do they move to their final positions?

-the ascending colon elongates and the cecum descends until the cecum and appendix lie in the LRQ.

56

when does the vitelline duct disappear?

once the final position of the intestines is attained

**results in the ascending colon and descending colon becoming secondarily retroperitoneal

57

derivatives of the hindgut

-distal 1/3 of transverse colon
-descending colon
-sigmoid colon
-rectum
-superior part of anal canal
-urinary bladder and urethra

58

endoderm --> embryonic folding --> ?? --> ??

--> gut tube --> foregut, midgut, hindgut

59

foregut --> ??

--> esophagus, stomach, liver, gallbladder, pancreas, proximal duodenum

60

stomach --> rotations --> ??

--> greater & lesser sacs & spleen swing left; distal duodenum and pancreas become secondarily retroperitoneal

61

growth of dorsal mesentery of stomach --> ??

--> greater omentum

62

hepatic diverticulum --> ??

--> bile duct + liver

63

bile duct --> ?? --> ??

--> cystic diverticulum --> gallbladder

64

ventral pancreatic bud + dorsal pancreatic bud --> dorsal rotation of ventral pancreatic bud --> ??

--> secondarily retroperitoneal pancreas

65

midgut --> midgut loop --> herniation into umbilical cord --> 270* total CCW rotation --> ??

--> small intestines + ascending t/v colon; ascending colon and descending colon become secondarily retroperitoneal

66

hindgut --> ??

--> descending colon + sigmoid colon + rectum + proximal anus

67

visceral layer of lateral plate mesoderm -->

--> serous membranes + dorsal mesentery + spleen