Quiz 9 Flashcards Preview

Pharmacology III > Quiz 9 > Flashcards

Flashcards in Quiz 9 Deck (25):
1

How do alkylating agents work?

1. Cross-linkage of DNA
2. Breaks DNA
3. Activator of cell cycle checkpoints resulting in apoptosis

2

How do abx CA agents work?

Bind to DNA
1. Produce free radicals
2. Damage DNA as single-strand breaks or cross-links

3

How do mitotic spindle inhibitors work?

inhibit kinetochores causing improper attachment to spindle microtubules
Cells exit mitosis or dies

4

How do antimetabolites work?

Structurally similar to purine/pyrimidines
1. Misincorporation into DNA
2. Abnormal timing or progression through DNA synthesis
3. Altered function of purine/pyrimidine biosynthetic enzymes

5

Stimulate WBC

Colony stimulating factors
1. Filgrastin - Neupogem - G-CSF
2. Sargramostim - Leukine - GM-CSF

6

What onco drugs can cause severe diarrhea?

1. 5-fluorouracil
2. Irinotecan

Tx - Hydration, electrolytes, Loperamide, Octreotide if resistant

7

Which onco drugs cause ~100% hair loss?

1. Anthracyclines
2. Alkylating inhibitors
3. Topoisomerase inhibitors

8

Tx advanced prostate CA

1. Elimination of testosterone production
2. LHRH w/ antiandrogen

9

Where do LHRH agonists work?

Hypothalamus sit on receptors inc. T but then it shuts down

Causes same T levels as surgical castration
Sx get worse, then good!

10

What are the LHRH agonists?

1. Goserelin - Zoladex
2. Histrelin - Vantas
3. Leuprolide - Lupron
4. Triptorelin - Telstar

11

What are the antiandrogens?

1. Abiraterone - Zytiga
2. Bicalutamide - Casodex
3. Enzalutamide - Xtandi
4. Flutamide
5. Nilutamide - Nilandron

**Used in combination therapy
CYP3A4 & 2C19

12

Tx closed angle glaucoma

Laser surgery

13

Tx open angle glaucoma

1. Prostaglandin analogs
2. Beta-blockers
3. Miotics
4. Carbonic anhydrase inhibitors
5. Adrenergics

14

Prostaglandin analogs

1st line Tx for open angle glaucoma
1. Travoprost - Travatan Z
2. Bimatoprost - Lumigan
3. Latanoprost - Xalatan

Causes eyelashes to grow

15

Beta lockers for open angle glaucoma

Timolo - Timoptic

Avoid in asthma, COPD, advanced cardiac disease

16

Miotics

Open angle glaucoma
1. Carbachol
2. Pilocarpine

Causes visual changes - dec. vision at night

17

Carbonic anhydrase inhibitors

Open angle glaucoma
1. Dorzolamide - Trusopt
2. Brizolamide - Azopt
3. Acetazolamide - Diamox (PO)

Weird taste, superficial punctate keratitis

18

Andrenergics for open angle glaucoma

Brimonidine - Alphagan P

Macular edema, redness, irritation

19

What drugs might inc. IOP?

1. Antihistamines
2. Anticholinergics - oxybutynin, tolterodine, benztropine, trihexylphenidine, TCAs
3. Chronic steroids
4. Topiramate

20

Antihistamines for allergic conjunctivitis

1. Naphazoline & Pheniramine
Use for 72h due to rebound vasodilation
2. Ketotifen

21

Tx bacterial conjunctivitis

1. Erythromycin (ointment)
2. Polymyxin-trimethoprim (drops)

22

AREDS formulation

Prevent progression of Dry AMD
1. Vit C
2. Vit E
3. Zinc oxide
4. Copper oxide
5. Beta-carotene or Lutein/Zeaxanthin

23

Tx Wet AMD

VEGF - Vascular endothelial growth factor inhibitors

1. Pegaptanib - Macugen
2. Bevacizumab - Avastin
3. Afilbercept - Elyea
4. Ranibizumab - Lucentis

ADRs
1. Retinal detachment
2. Hypersensitivity
3. Inc. IOP
4. Thromboembolic events
5. Visual disturbances

24

No tears due to ocular inflammation?

Cyclosporin - Restasis
Immunomodulator

25

Tx claudication

1. Cilostazol - Pletal
2. Clopidogrel/Aspirin
3. Pentoxyfylline - Trental