Quiz 8 Reverse

Question 1

1. OTC cold meds2. Allergy meds3. Antihypertensives4. Antiarrhythmics Also - long periods of immobility

Answer 1

Drugs that may cause acute BPH

Question 2

1. Alpha-blockers2. 5 alpha-reductase inhibitors3. Phosphodiesterase-5 inhibitors

Answer 2

Classes of drugs to Tx BPH

Question 3

1. Flomax - Tamsulosin2. Uroxatral - Alfuzosin

Answer 3

Alpha blockers for BPH

Question 4

alpha 1A & 1D Avoids alpha 1B affect so doesn’t effect BPFor BPH

Answer 4

Which receptors does Flomax affect?

Question 5

Work only on prostate to dec. 5DHT

Answer 5

How do 5-alpha reductase inhibitors work?

Question 6

6-12 monthsResets PSA levels - get new baseline

Answer 6

How long does it take to see effects from 5-alpha reductase inhibitors?

Question 7

ex. Avodart - Dutasteride1. Dec. libido2. Ejaculatory disorder3. Gynecomastia4. ImpotenceMaybe1. Cardiac failure2. Inc. TSH levels3. Testicular swelling4. Rash, urticaria

Answer 7

ADRs 5-alpha reductase inhibitors

Question 8

1. Androgens - testosterone2. Phosphodiesterase inhibitors3. Andrenergic-receptor antagonists

Answer 8

Types of drugs for erectile dysfunction

Question 9

1. Nitrate therapyCaution w/ alpha-blockers

Answer 9

Contraindications to phoshodiesterase-5 inhibitors

Question 10

Increase cGMP so blood stays in penis

Answer 10

MOA phosphodiesterase-5 inhibitors

Question 11

Cialis - TadalafilUsed for ED & BPHMay cause back pain/myalgias

Answer 11

Which phosphodiesterase-5 inhibitor can be used every day?

Question 12

SSRIs

Answer 12

What drugs might cause female sexual dysfunction?

Question 13

Ospemifene - selective estrogen receptor modulator

Answer 13

Tx dyspareunia assoc. w/ vulvovaginal atrophy

Question 14

1. Estrogen - localNot good:2. Testosterone creams & gels3. Sildenafil - Viagra

Answer 14

Drugs to treat female sexual dysfunction

Question 15

Administration of therapeutic agents before a main Tx1. Reduce size or extent of CA2. Determine response or resistance to a given agent3. Try to make subsequent therapy easier & more likely to succeed

Answer 15

What is neoadjuvant therapy?

Question 16

Tamoxifen - NovaldexProdrug - CYP2D6 Drug interaction - antidepressantsADRs1. Inc. risk of stroke2. Flushing3. Nausea4. Fluid retention5. Vaginal bleeding & d/c6. Endometrial hyperplasia

Answer 16

Name a selective estrogen receptor modulator

Question 17

CYP19A1Prevent production of estrogen

Answer 17

How do aromatase inhibitors work?

Question 18

Women w/ intact ovaries - reactivation possible leading to inc. levels of estrogen Good in postmenopausal women

Answer 18

Who should avoid aromatase inhibitors?

Question 19

Ex. Anastrozole Higher incidence than Tamoxifen1. Osteoporosis2. Fx3. CV risk4. Hypercholesterolemia5. MSK issuesLower risk of 1. Venous thrombosis2. Endometrial CAADRs1. Vasodilation2. Fatigue3. Hot flashes4. GI distress5. Mood disorder

Answer 19

ADRs Aromatase inhibitors

Question 20

Lapatinib - Tykerb Oral - metabolized by CYP3A4Eat on empty stomach - adequate hydrationDon’t drink grapefruit juice! Can inc. drug levelsADRs1. GI2. Acneform rash3. Cardiac toxicity

Answer 20

What are the anti-her2 agents & ADRs?