random Endocrine Flashcards

1
Q

what is kleinfelters syndrome

A

when boys have an extra X chromosome XXY

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2
Q

what are the hormone profile results of premature ovarian failure

A

high FSH and LH and low oestrogen

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3
Q

hormone profile in type 1 hypothalamic failure

A

low FSH, LH and low oestrogen

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4
Q

chocolate cysts on ovary

A

endometriosis

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5
Q

name some causes of male infertility

A
hypogonadotrophic hypogonadism 
kallmans syndrome, kleinfelters syndrome, chemotherapy, radiotherapy, undescended testes, idiopathic
hyperprolactinaemia 
acromegaly
cushings disease
hyper or hypothyroidisim
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6
Q

what are the intrinsic muscles of the larynx supplied by

A

all intrinsic muscles of the larynx, posterior cricoartytenoid, lateral crico artenoid, arytenoids and thyroidarytenoids are supplied by inferior laryngeal nerve (branch of CNX)
cricothyroid muscle is innervated by the external laryngeal nerve

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7
Q

what does the inferior laryngeal nerve supply

A

posterior and lateral cricoartyenoid muscles, arytenoids and throarytenoid muscles

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8
Q

what does the external laryngeal nerve innervate

A

cricothyroid muscle

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9
Q

what is mucosa above the fold supplied by

A

internal laryngeal nerve

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10
Q

what is mucosa below the fold supplied by

A

inferior laryngeal nerve

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11
Q

where does the left recurrent laryngeal nerve become the inferior laryngeal nerve

A

at the level of the cricothyroid joint

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12
Q

where does the left recurrent laryngeal nerve travel

A

under the aortic arch

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13
Q

where does the right recurrent laryngeal nerve pass

A

under the right subclavian artery

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14
Q

where does the vagus nerve pass though in the base of the skull

A

the jugular foramen

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15
Q

what are the otic placodes and what do they give rise to

A

they are thickenings of the ectoderm, one on each side overlapping the hindbrain (rhoboencephalon)
they give rise to the otic capsule which give rise to the inner ear

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16
Q

what does the first pharyngeal cleft give rise to

A

the external auditory meatus

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17
Q

what does the first pharyngeal pouch give rise to

A

Eustachian tube, tympanic membrane and middle ear

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18
Q

what does the second pharyngeal pouch give rise to

A

PALATINE tonsil

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19
Q

what gives rise to the inferior parathyroid glands and thymus

A

3rd pharyngeal pouch

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20
Q

what is formed from the 4th pharyngeal pouch

A

superior parathyroid glands

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21
Q

what gives rise to the inner ear

A

otic placodes which form otic capsule

22
Q

how is neurofibromatosis inheritied

A

autosomal dominant

23
Q

what are the features of neurofibromatosis type 1

A

café au lait spots more than 6/7, widespread neurofibromas, bony defects, axillary frecking and lisch nodules

24
Q

features of neurofibromatosis 2

A

bilateral vestibular schwannoma, multiple menigiomas, gliomas, café au lait, may have hearing loss, cataracts and muscle wasting

25
what is the protein defect in NF2
merlin
26
are nasal polyps common in children
no if found consider cystic fibrosis
27
what are the pathological features of nasal polyps
oedema of lamina propria, inflammatory change often including eosinophils scattered stroma atypia
28
what is Wegeners caused by
autoimmune
29
what can wegeners cause
pulmonary, renal disease and septal perforation
30
where is nasopharyngeal carcinoma common and why
far east due to greater prevalence of EBV and volatile nitrosamines in food
31
what else is EBV associated with
burkitts lymphoma, other B cell lymphomas and hodgkins lymphoma
32
how does EBV cause the cancer
hi jacks and mimicks helper T cell responses leading to proliferation and survival of B cells LMP-1 latent membrane protein 1 and EBV encodes EBNA-2 which promotes transiton form G0-G1
33
difference in nodules and polyps
nodule are usually seen in younger women and are bilateral on middle 1/3 to posterior 1/3 on vocal cord polyps are unilateral and pedunculated
34
what is a papilloma
benign epithelial tumour that grows with fronds associated with HPV viruses types 6 and 11 in head and neck
35
what is a paraganglioma
tumours arising in clusters of neuroendocrine cells
36
name some chromaffin positive ells
sympathetic nervous system and can secrete catecholamines, usually adrenal medulla or paravertebral-organ of zuckerkandle
37
non chromaffin cells
neuroendocrine cells eg carotid and aortic bodies, lots more
38
causes of squamous cell carcinoma
smoking and alcohol | and in oropharynx HPV
39
what type of HPV is associated with squamous cell carcinoma
type 16
40
how does HPV cause SCC
produces proteins E6 and E7 which disrupt Rb and P53 pathways leading to cellular immortality
41
what is sialolithiasis
stones in the salivary glands
42
tumours in large glands are more likely to be
BENIGN
43
tumours in smaller glands are more likely to be
MALIGNANT
44
which salivary gland is most common for tumour
PAROTID
45
what is a pleomorphic adenoma
BENIGN tumour, most common in parotid and in females greater than 50 varying morphology epithelial and myoepithelial cells present in chondromyxoid stroma require wide excision small risk of malignant transformation
46
what type of tumour is a Warthins tumour
BENIGN
47
where is a Warthins tumour found
most commonly in the parotid
48
what is a warthins tumour made up of cellularly
mixture of bilayer oncocytic epithelium with dense lymphoid infiltrate
49
what type of cancer is a mucoepidermoid carcinoma
a malignant
50
what type of cells is a mucoepidermoid carcinoma made up of
mixture of squamous, intermediate and mucinous epithelium | varying grade