Rats

Question 1

Genus species of rats most commonly used for research

Answer 1

Rattus norvegicus (Brown Norway Rat)

Question 2

T or F. Rats do not have a gallbladder

Answer 2

T

Question 3

How many pairs of mammary glands to rats have?

Answer 3

6

Question 4

What laboratory animal species lack haversian canals in their bones?

Answer 4

Rats, mice and hamsters

Question 5

What is the range of appropriate light intensity at the cage level for rats?

Answer 5

130-325lux

Question 6

Which mutant strain of rat is a model for Diabetes insipidus?

Answer 6

Brattleboro

Question 7

What is the unique characteristic of the Gunn rat

Answer 7

-jaundice, kernicterus

Question 8

What is the the Zucker rat used to study?

Answer 8

obesity

Question 9

Which rat strain is used for National Tox Program’s Carcinogen Bioassay

Answer 9

Fischer 344

Question 10

Which inbred strain is useful as a model of autoimmune thyroiditis

Answer 10

Buffalo

Question 11

What is the Lewis rat commonly used to study?

Answer 11

multiple sclerosis and other autoimmune disease

Question 12

In what type of research is the SHR inbred strain of rat used?

Answer 12

spontaneous hypertensive rat

cardiovascular disease and hypertension research

Question 13

What are the 2 most commonly used outbred

stocks of rats.

Answer 13

Sprague-dawley

Wistar

Question 14

Is the harderian gland located medial or lateral to the orbit?

Answer 14

medial

Question 15

What is the term used to describe excessive secretions of the Hardarian gland

Answer 15

Chromodacryorrhea

Question 16

Name a frequently used purified diet for rats

Answer 16

AIN-76

Question 17

What is the diploid number of chromosomes for Rats

Answer 17

42

Question 18

What is the etiologic agent of Pseudotuberculosis in a rat

Answer 18

Corynebacterium kutscheri (gram positive)
-abscesses in the lungs, liver, kidneys, skin jones

Question 19

What is the hallmark lesion of Tizzer’s disease in the rat

Answer 19

coagulative necrosis of the liver

Question 20

What is the etiologic agent of rat-bite fever?

Answer 20

Streptobacillus moniliformis (gram neg bacillus)
non pathogenic in rats
rare in modern rat colonies

Question 21

Cilia-associated Respiratory Bacillus (CAR bacillus) are classified as what type of bacteria

Answer 21

“gliding

Question 22

What are common clinical signs of CAR bacillus in rats?

Answer 22

usually asymptomatic

Question 23

What is the classic lesion of Mycoplasma pulmonis infection in adult rats (which is rarely seen these days)

Answer 23

“cobblestone” lung

Question 24

What is the etiologic agent of Hemobartonellosis in a rat

Answer 24

Mycoplasma haemomuris

-gram negative bacteria that parasites rat erythrocytes

Question 25

How is M haemomuris transmitted

Answer 25

by the spiny rat louse

Question 26

Give the genus and species of the spiny rat louse

Answer 26

polyplax spinulosa

Question 27

To what family does Sendai virus belong? | RNA or DNA

Answer 27

Paramyxoviridae | RNA

Question 28

T or F. Sendai virus has a similar presentation in rats as mice

Answer 28

F. It is asymptomatic and self limiting in Rats

Question 29

Name the 2 prototypic coronaviruses of rats

Answer 29

Parker's Rat corona virus (RCV-P) Sialodacryoadenitis virus (RCV-SDA) (neutralizing antibody to one prototype, will not offer cross protection from the other) -enveloped RNA

Question 30

Name the parvoviruses that infect rats

Answer 30

RV- rat virus (Kilham's rat virus) H-1 virus (Toolan's) RPV-Rat parvovirus RMV- rat minute virus

Question 31

List some characteristic of parvoviruses in general

Answer 31

single stranded DNA virus | -infect rapidly dividing cells

Question 32

What is the inclusive species name that now includes all the mouse and rat parvoviruses

Answer 32

Rodent protoparvovirus 1

Question 33

T or F. RV has a tropism for T-cell lymphocytes

Answer 33

T

Question 34

What is the family and characteristics of hantavirus?

Answer 34

genus- hantavirus, family bunyviridae | -enveloped RNA

Question 35

For which Hantavirus is Rattus norvegicus natural host?

Answer 35

Seoul Hantavirus- agent of Hemorrhagic fever with renal syndrome (HFRS) in humans

Question 36

What is the most common oxyurid of the rat?

Answer 36

Syphacia muris

Question 37

What are the most common clinical signs and pathology associated with Syphacia muris in the Rat

Answer 37

None

Question 38

What tissue/organ does the nematode Trichosomoides crassicauda inhabit in the rat?

Answer 38

Urinary bladder

Question 39

Name the fur mite most likely to be encountered in rats

Answer 39

Radfordia ensifera

Question 40

How is Pneumocystis carnii transmitted to rats

Answer 40

airborne transmission | or possible through soiled bedding

Question 41

What is the hallmark histologic lesion noted in the lungs of rats infected with Pneumocystis carny

Answer 41

perivascular lymphocytic cuffing

Question 42

Which strain of rat has a high incidence (near 100%) at 3-4months of age of eosinophilic granulomatous pulmonary inflammation, with no determined etiology?

Answer 42

Brown Norway

Question 43

Which strains of rat are prone the polyarteritis?

Answer 43

Sprague-Dawley and SHR

Question 44

Which strain of rat is mostly likely to have a testicular tumor, and what type of tumor will it likely be?

Answer 44

F-344 | interstitial cell

Question 45

What type of pituitary tumors are most common aged rats?

Answer 45

chromophobe adenoma

Question 46

What strain of rat is likely to have a large granular lymphocytic leukemia?

Answer 46

F-344 - initial site of malignancy is spleen - splenomegaly common