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Rbc Flashcards

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1
Q

Extravascular Hemolytic anemia

A

Anemia splenomeg jaundixe

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2
Q

Anemia hb hburia hemosiderunria jaundice

A

Intravascular Hemolytic anemia

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3
Q

Hemolytic anemia

A

Normonlastss, reticulocytosis, cholelith

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4
Q

Morphology of Hemolytic anemia

A

Normochtic, normochromoic

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5
Q

Genetic of hereditary apherocytosis

A

Ad

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6
Q

Spheorid cell, less deformable

A

hereditary apherocytosis

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7
Q

Mutation of ankyrin band 3 /

Spectrin

A

hereditary apherocytosis

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8
Q

Congestion of cords of billroth inc # of cords of billroth, inc phagocytes in spleen

A

hereditary apherocytosis

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9
Q

Due to parvovirus b19

A

hereditary apherocytosis

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10
Q

Due to env mononuc

A

hereditary apherocytosis

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11
Q

Small dark nuclear remants preaent n rbc os asplenic pts

A

Howell jolly bodies in splenomegaly

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12
Q

Xnlinked recessive disorder, reduce ability rbc to protect themselves agaisnt oxidative ij and lead to hemolysis

A

G6pd

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13
Q

What infn causeG6pd

A

Biral hepa, pneumonia, typhoid fevery

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14
Q

Drugs cause G6pd

A

Antimalarial, sulfa, nitrofurantoin

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15
Q

Protective against malaria

A

G6pd

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16
Q

Rate lim of pp

A

G6pd

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17
Q

Reduce nadp to nadph

A

G6pd

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18
Q

Membrane bound precipitates in denatured globin chains

A

Heinz bodies

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19
Q

Rbcs wt damaged membranes

A

Bkte cells

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20
Q

Acute intravasculae hemolysis wrhin 2-3 days- anemia, hbnuria, hbnemia

A

G6pd

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21
Q

Recovery helarded by reticuloscytosis

A

G6pd

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22
Q

Autosomal recessive hemoglobinopathy, african

A

Sickle cell anemia

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23
Q

Small nuclear remannts in rbc dt asplenia

A

Howell jolly

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24
Q

Trapping of sickles cell leads to splenic fibrosis

A

Autosplenectomy

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25
Dehydrated rbcs wt bulls eye appearance
Trget cells
26
Rbc like curved blades
Sickled cellt
27
Episode of hupoxid inj and infarct
Vasooclusive crisis
28
Massive entrapment of sickles crll leads to rapud splenic enlargemnt hypovolemia
Sequestration crisi
29
Infection of rbc progenitors by parvo b19
aastoc anemia
30
Inability to con urine
Hypostjenuria
31
Inc susceptibility wr encapsulated organis
Sickle cell
32
Prom cheeckbones, crewvut skull appearnce
Sickle cell
33
Best initial dx for sickle cell
Pbs
34
Dx gold standard
hb electropheresis
35
Doc fir sickle crll ania
Hydroxyurea
36
Chipmunk facies, crew cut skull, splenomegaly, hemochromotasosi
Thalassemia
37
Codixytes
Thalassemia
38
Basophilic stippling
Thalassemia
39
Microcytic hupochrmoic
Thalassemia
40
1 tx for hemochromatosi
Phleb
41
Id nonresponsive
chelation wt deferoxamine
42
Intravasculat hemolysis dt inc complement mediated rbc lysis
Pnh
43
Dx of pnh
Flow cytometry
44
Low rbc during sleep
Pnh
45
Rm temp death of rbc
Warma agglutinin
46
Death rbc by col
Cold aglutinin seen wt mycoplasma pn
47
Ig cold hot
Igm igg
48
Igg ti bloodw
Direct coombs
49
Normal rbc to pts serum
Indirect coombs
50
Rbc damaged thru passing narrowed vessels
Microangiopathic
51
Microangiopathic seen in
Dic, ttp, hus, sle
52
Morpho microangiopathic
Sccjistocytes, blur cell
53
Impairment if dna synt leads to distinctive morphologic chanes
Megaloblastic anemia
54
Morph of megaloblastic
Macoovalocyte if rbc, hypersegmented neutr
55
Diff deficiency if vit b12 folate👻
Neurologic sx🎅
56
Parasituc infxn of megaloblastuc
Diphy🎣
57
Tx 🎣
Prai
58
Caused by autoimmune gastritis and fec if
Pernicious anemia
59
Atrophy of fundic glands, intestinaluziation
Pernicious anemia
60
Shiny glazed beefy tongue
Pernicious anemia
61
Demyelination of dirsala nd lat tracts of sc
Pernicious anemia
62
Stage 1 scholling
Vit b12
63
Schilling stage 2
If
64
Low stage 1 nirmal stage 2
Pernicious anemia
65
Parasitic infxn lead to microcytic hypochromic anemia
Hookworms
66
Doc for hookworlms
Albendazole
67
Morpho ida
Disappearance if stainable iron fr macrophages in marrow in prissiona blu
68
S/sx o ia
Pica, plummer vinson syndrome ( esophageal webs, atrophic glossitis
69
Stimulate hepcidin
6
70
Reduce iron transerfr stirage pool to bone marriw
Hepsidin
71
Syndrome of chronic primary hematopoietic failure and atendant pancytopenia
Aplastic anemia
72
Ab cause idiosyncratzic aplastic anemia
Chloram
73
Chemical causes aplastic anemia
Benzene
74
Morph aplastic anemia
Hypocellular bm wt fat cells dry tap
75
Diff aa and myelodysplastic anemia
Mds has hypercellular
76
Selective hypoplasia of marriw erythroid. Normal granulpoiesis and thrombopoiesus
Pure red cella palsia
77
Plt less than 100,00
Thrombocytopeniat
78
Spont blleed
79
Caused bu antipaletelet antibidy
Itp
80
Sec to viral infxn
Ito
81
Morfo itp
Congestionnof sinusoids enlargement of follicles, megathrombocytes
82
Mist feared complication of itp
Intracranial bleed
83
Tx ito
Glucocorticoid, splenectomy, rituxab
84
Spectrum of ttp and hus
Thrombotic microangiopathis
85
Pentad if ttp
Fever, thrombocytopenia, mha, neuro def, renal failure
86
Triad hus
Microangiopathic hemolytic anemia, thrombocytopenia, renal failure
87
Def of adamst13
Ttp
88
Causes by shiga like toxin ehec
Hus
89
Inc bleeding time
Platelet dysfxn
90
Defective plt adhesion
Bernard soulier
91
Dec gp 2b-3a
Glanzman
92
Sx of bleeding + normal platelet
Vwd
93
Tx of vwd
Desmoprrssin
94
Most common life threatening assoc wt life threatening bleeding
Hemophilia a
95
Chrisas disease
Heophilia b
96
Acute, subacute or chronic thrombohemorrhaguc disorder
Dic
97
Causes of dic
Sepsis, trauma, obstetric comp, pancreetitis, malig, mephrotic synd, transfusion
98
Fibrin thrombi lead to massive adrenal hemorrhages
Water friderichsen synd
99
Post partum pituitary necrosi
Sheehan synd
100
Widespread microtjrombi onnplacenta
Toxemia n preg
101
Tests for dic
Fibrinogen, plt, pt/ptt, fibrin, degradation products
102
Premature destruction of rbc, elev erythropoeitin level. Accumulation of hb pro
Hemolytic anemia

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