RBC Development

Question 0

What are the functions of platelets?

Answer 0

Cellular fragments from megakaryocyte
Adhere & aggregate to a wound
Initiate coagulation cascade

Question 1

What is the lifespan of a mature erythrocyte?

Answer 1

120 days

Question 2

What is erythropoiesis?

Answer 2

RBC production

Question 3

Where does erythropoiesis occur?

Answer 3

Axial skeleton

Question 4

What is erythropoietin?

Answer 4

A growth factor hormone produced in the kidney

Question 5

How are RBCs produced?

Answer 5

Red cell precursors divide into daughter cells that can also divide in 3 successive reductions

Question 6

What are the sites of erythropoiesis in regards to age?

Answer 6

Prenatal 0-6 weeks: Yolk Sac
Prenatal 6-18 weeks: Liver
Prenatal 18-36 weeks: Spleen
Birth: Bone marrow

Question 7

What is the ratio of myeloid cell precursors to erythroid cell precursors?

Answer 7

4:1

Question 8

Where is the site for bone marrow collection?

Answer 8

Posterior superior iliac crest

Question 9

Where does red cell maturation occur?

Answer 9

Bone marrow

Question 10

Where is the most appropriate site for bone marrow collection in newborns & infants?

Answer 10

Upper end of the tibia

Question 11

What cell do blood cells originate from?

Answer 11

Myeloid stem cell

Question 12

List the red cell maturation sequence (RBC precursors)

Answer 12

Pronormoblast
Basophilic Normoblast
Polychromatic Normoblast
Orthochromatic Normoblast
Polychromatic Erythrocyte
Erythrocyte

Question 13

What is the first cell in the RBC precursor series?

Answer 13

Pronormoblast

Question 14

What is the the size of a pronormoblast?

Answer 14

14-24 microns

Question 15

What are some features of the nucleus and cytoplasm of a pronormoblast?

Answer 15

Large round reddish blue nucleus

Blue cytoplasm

Question 16

What are two distinguishing features of a pronormoblast?

Answer 16

Prominent nucleoli

Perinuclear halo

Question 17

What is the second cell in the RBC precursor series?

Answer 17

Basophilic normoblast

Question 18

What is the size of a basophilic normoblast?

Answer 18

12-17 microns

Question 19

What are some features of a basophilic normoblast?

Answer 19

Coarsened chromatin
Nucleoli ill defined or absent
Mostly blue (RNA) cytoplasm

Question 20

What is the third RBC precursor in the series?

Answer 20

Polychromatic normoblast

Question 21

What is the size of a polychromatic normoblast?

Answer 21

10-15 microns

Question 22

What are some features of a polychromatic normoblast?

Answer 22

Cytoplasm has some pink due to hemaglobin presence & blue due to RNA

Question 23

What is special about a polychromatic normoblast?

Answer 23

It is the last precursor to be able to divide

Question 24

What is the fourth in the RBC precursor series?

Answer 24

Orthochromatic normoblast

Question 25

What are some features of an orthochromatic normoblast?

Answer 25

Solid blue black degenerated nucleus Cytoplasm mostly pink "Pkynotic"nucleus has no parachromatin Cell cannot divide

Question 26

What is the fifth cell in the RBC precursor series?

Answer 26

Polychromatophilic erythrocyte "retic"

Question 27

What size is a polychromatophilic erythrocyte?

Answer 27

8-10 microns

Question 28

What are some features of a polychromatophilic erythrocyte?

Answer 28

Cell has bluish tint, mostly pink Circulates 1-2 days while it matures Frequently seen in blood of newborns Increased number seen in hypoxia

Question 29

What are features of a mature erythrocyte?

Answer 29

7-8 microns, no nucleus | Pink cytoplasm

Question 30

What is a mature erythrocyte unable to synthesize?

Answer 30

Hemaglobin

Question 31

What is a reticulocyte?

Answer 31

Polychromatophilic erythrocyte

Question 32

What are two names for pronormoblast?

Answer 32

Proerythroblast | Rubriblast

Question 33

What are two names for basophilic normoblast?

Answer 33

Basophilic erythroblast | Prorubicyte

Question 34

What are two names for polychromatophilic normoblast?

Answer 34

Polychromatophilic erythroblast | Rubricyte

Question 35

What are two names for orthochromatic normoblast?

Answer 35

Orthochromatic erythroblast | Metarubricyte

Question 36

What are other names for a reticulocyte?

Answer 36

Polychromatophilic erythrocyte | Diffusely basophilic erythrocyte