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Hematology Module 1 and 2 > RBC Metabolism > Flashcards

Flashcards in RBC Metabolism Deck (36):
1

Identify the three areas of cel metabolism that are crucial for normal erythrocyte survival and function.

1) RBC membrane
2) Hemoglobin structure and funciona
3) RBC metabolic pathways

2

Is Glycophorin integral or peripheral? What is its function?

Integral, negative charge and location of antigens

3

Is Spectrin integral or peripheral? What is its function?

Peripheral, strengthen and perserve deformability

4

State the structural defects to produce Acanthocytes.

Increase in surface areas = Decrease in intracellular HGB

5

State the structural defects to produce Bite Cells

Decrease in Spectrin

6

State the structural defects to produce Sphereocytes

Decrease in Spectrin

7

State the structural defects to produce Target Cells

Increase in surface area = Decrease in intracellular HGB

8

What is the protein that delivers iron?

Transferrin

9

What are the two major tissues where heme synthesis occurs?

BM and liver

10

Draw Diagram of Heme synthesis! Begin with Succinyl Coenzyme A and glycine and end with heme

Back of PP

11

Describe the chemical structure of heme

2 Alpha Chains and 2 non alpha chains

12

What is the reason for "ringed sideroblasts?"

Mitochondrial Buildup of Iron

13

What is the reason for freshly voided urine from a patient with porphyria to not be red?

Has not oxidized yet

14

What are the three hemoglobins found in the embryo?

Grower 1, grower 2 and Portland

15

What is the composition and names of the 3 global chains and what are the percentages of each?

A = 2 alpha and 2 Beta, >95%
A2 = 2 Alpha and 2 Delta, 1.5-3%
F = 2 Alpha and 2 Gamma,

16

Characterize the oxygen affinity of R (relaxed) and T (tense) hemoglobin.

R is affinity for O2
T has a lower affinity for O2

17

What happens in a left shift and where does it occur?

Uptake of O2 , lung

18

What happens in a right shift and where does it occur?

Release of O2, Tissue

19

What happens to PH, 2-3 DPG levels, and Temperature in a shift to the left?

PH increases
2,3 DPG levels decreases
Temperature decreases

20

What happens to PH, 2-3 DPG levels, and Temperature in a shift to the right?

PH decreases
2,3 DPG levels increases
Temperature increases

21

List the three abnormal hemoglobins that are unable to transport or deliver oxygen.

Carboxyhemoglobin
Methemoglobin
Sulfahemoglobin

22

State the main source of ATP production in mature RBCs

Mitochondria

23

Name that metabolic pathway that generates most of the RBC ATP.

Emden meyerhof Pathway

24

State the major function of Eden Meyerhof pathway.

Anaerobic glycolysis = energy

25

State the major function of Hexose monophosphate shunt.

Protects RBCs from environmental oxidants

26

State the major function of Methemoglobin Reductase Pathway.

Maintains iron in the ferrous (2+) state

27

State the major function of Leubering-Rapport Shunt.

Synthesis of 3,3 DPG

28

State that changes in RCS leading to demise in 120 days

As enzymes break down, lose of energy production and deformability and can't not get through he cords of the spleen = phagocytize by RES cells.

29

Compare and contrast steps in extravascular Versus Intravascular breakdown of RBCs

(on back of objectives)
Extravascular = 90%, within RES cells, RES phagocytize, Iron is couples to transferrin, Bilirubin to Urobilinogen and excreted
Intravascular= 10%, within blood vessels, Haptoglobin pricks up free HGB, go to liver where Bilirubin to Urobilinogen and excreted

30

What is the level of Haptoglobin in the presence of intravascular hemolysis?

Decreased

31

State the main protein carrier for Bilirubin

Albumin

32

State the main protein carrier for Hemoglobin

Haptoglobin

33

State the main protein carrier for Iron

transferrin

34

Define Porphyria

Disorder of heme synthesis

35

Define Porphyrin

Oxidized porphyrinogen, stable, florescent pinkish-red "port wine"

36

Define Porphyrinogen

Precursor to Porphyrin, colorless, non fluorescent, highly unstable. Quickly oxidizes to porphyrin