Macrocytic anemia Flashcards Preview

Hematology Module 1 and 2 > Macrocytic anemia > Flashcards

Flashcards in Macrocytic anemia Deck (32):
1

What is the impaired component of megaloblastic anemia?

DNA

2

What are the three general causes for megaloblastic anemia?

B12 Deficiency, Folate Deficiency and Drugs that interfere with DNA metabolism

3

What are the megaloblastic changes in BM of RBCs, WBCs and Platelets?

RBCs, Large and asynchronous maturation
WBCs, Giant forms (metas/Bands) asynchronous maturation
Platelets = Giant platelets

4

What are the megaloblastic changes in PB of RBCs, WBCs and Platelets?

RBC= Oval macrocytes, teardrops, H-J, Cabot rings,
WBC = WBCs, Giant forms (metas/Bands) also Have HYPERsegs (>5 lobes
Platelets = Giant

5

What are the reasons for Cabot rings in megaloblastic anemia?

Ineffective hematopoiesis

6

What are the reasons DECREASED retic count in megaloblastic anemia?

Ineffective hematopoiesis

7

What are the reasons for H-J bodies in megaloblastic anemia?

Ineffective hematopoiesis

8

What are the reasons for hyperplastic BM and panocytopenic PB and in megaloblastic anemia?

Ineffective hematopoiesis

9

What are the reasons for hyper segmented neutrophils in megaloblastic anemia?

Ineffective hematopoiesis

10

What is the reason for increased MCV in megaloblastic anemia?

Fewer cell divisions

11

What is the reason for macroovalacytes in megaloblastic anemia?

Fewer cell divisions and asynchronous maturation

12

what is the reason for teardrop cells in megaloblastic anemia?

Crowding effect

13

What are the expected results for serum bilirubin in megaloblastic anemia?

Increased

14

What are the expected results for serum LDH in megaloblastic anemia?

Increased

15

What are the expected results for serum iron in megaloblastic anemia?

Increased

16

What is the function of intrinsic factor (IF) in B12 absorption?

Binds to it t for absorption

17

Where is the site of IF production?

Parietal cells of stomach

18

Where is the site of absorption of B12?

Ileum

19

Where is the site of storage for B12?

Liver

20

What are the clinical features of B12 deficiency?

Sore tongue (beefy red) and jaundice

21

What symptom is mostly unique to B12?

Neurological problems

22

What is the most common cause of B12 deficiency?

Impaired absorption

23

What is the defect in pernicious anemia which leased to impaired B12 absorption?

Inability of Mucosa to secrete IF

24

What does D. Latum or increased Bacteria flora cause B12 deficiency?

Competition

25

Where is the site of absorption of Folate?

Jejunum

26

What is the length of storage for folate?

4-5 months

27

What is the most common reason for flip acid deficiency?

Poor diet

28

What are the four reasons for increased folic acid?

Accelerate hematopoiesis
Pregnancy
Growth
Pregnancy

29

What are the three drugs that interfere with folate absorption?

Birth control, anti-TB drugs, dilantin and AZT

30

What RBC morphology do you expect with non-megaloblastic anemia?

round macrocytes, targets, stomatocytes and spur cells

31

What are the two causes for non-megaloblastic anemia?

Reticulocytosis, liver disease/alcoholism

32

What is the reason for targets in PB of a patient with Liver disease?

??????