Red Blood Cells And Bleeding Disorders

Question 0

Average content (mass) of hemoglobin per red cell expressed in picograms

Answer 0

Mean Cell Hemoglobin

Question 1

Average volume of a red cell expressed in femtoliters

Answer 1

Mean Cell Volume

Question 2

Average concentration of hemoglobin in a given volume of packed red cells expressed in grams per deciliter

Answer 2

Mean Cell Hemoglobin Concentration

Question 3

Coefficient of variation of red cell volume

Answer 3

Red Cell Distribution Width

Question 4

Inc RDW

Dec RDW

Answer 4

Iron deficiency

Thalassemia

Question 5

Hemolytic Anemias

Answer 5

Hereditary spherocytosis
G6PD deficiency
Sickle cell anemia
Thalassemia
Autoimmune HA
Microangiopathic HA
Macroangiopathic HA

Question 6

Mutations of ankyrin, spectrin, band 3 and band 4.2

Answer 6

Hereditary spherocytosis

Question 7

Hemolytic anemia
Aplastic crisis
Hemolytic crisis

Answer 7

Parvovirus B19

EBV mononucleosis

Question 8

Small dark nuclear remnants present in RBCs of asplenic patients

Answer 8

Howell Jolly bodies

Hereditary spherocytosis

Question 9

Symptoms of extravascular hemolysis

Answer 9

Anemia
Splenomegaly
Jaundice

Question 10

Symptoms of intravascular hemolysis

Answer 10

Anemia
Hemoglobinemia
Hemoglobinuria
Hemosiderinuria
Jaundice

Question 11

Episodic hemolysis

Answer 11

G6PD deficiency

Question 12

Triggers of G6PD deficiency

Answer 12

INFECTIONS
Drugs antimalarials sulfonamides
Fava beans

Question 13

Membrane bound precipitates on denatured globin chains

Answer 13

Heinz bodies

G6PD def

Question 14

RBCs with damaged membranes removed by splenic macrophages

Answer 14

Bite cells

Question 15

Recovery phase of G6PD deficiency heralded by

Answer 15

Reticulocytosis

Question 16

6th codon of B globin: glu to val

Answer 16

Sickle cell anemia

Question 17

RBCs shaped like curved blades

Answer 17

Sickled cells
Sickle cell anemia

Reticulocytosis
Howell Jolly bodies

Question 18

Trapping of sickled red s leading to splenic infarction

Answer 18

Autosplenectomy

Sickle cell anemia

Question 19

Types of crisis in Sickle cell anemia

Answer 19

Vasoocclusive
Sequestration
Aplastic

Question 20

Chronic tissue hypoxia
Hyposthenuria - cannot concentrate urine 
Infections
Prominent cheekbones
Crewcut skull appearace
Chronic hyperbilirubinemia

Answer 20

Sickle Cell Anemia

Question 21

Sickle cell anemia

Initial dx test

Answer 21

Periph blood smear

Question 22

Sickle cell anemia

Gold std

Answer 22

Hb electrophoresis

Question 23

Sickle cell anemia

DOC

Answer 23

Hydroxyurea

Question 24

``` Alpha thalassemia 1 2 3 4 ```

Answer 24

Silent carrier state A thalassemia trait Hemoglobin H disease Hydrops fetalis

Question 25

Beta thalassemias Transfusion dependence. HbF Severe but no transfusion Asx

Answer 25

Major cooley's anemia Intermedia Minor

Question 26

Dehydrated RBCs with bull's eye appearance

Answer 26

Target cells or codocytes | Thalassemia

Question 27

Basophilic stippling Anisocytosis Poikilocytosis Microcytic hypochromic anemia

Answer 27

Thalassemia

Question 28

Crew cut skull appearance Chipmunk facies Hemosiderosis Hemochromatosis

Answer 28

Thalassemia

Question 29

Treatment for hemochromatosis

Answer 29

Phlebotomy

Question 30

DOC for hemochromatosis

Answer 30

Deferoxamine chelation

Question 31

Leading cause of death in PNH

Answer 31

Thrombocytosis

Question 32

Warm agglutinin | Cold agglutinin

Answer 32

IgG | IgM

Question 33

Autoimmune HA seen in SLE, CLL or methyldopa

Answer 33

Warm agglutinin

Question 34

Autoimmune HA seen in Mycoplasma and mononucleosis

Answer 34

Cold agglutinin

Question 35

Anti Ig antibody added to patient's RBCs agglutinate if RBCs are coated with Ig

Answer 35

Direct Coombs' Test

Question 36

Normal RBCs added to serum agglutinate if serum has Ig

Answer 36

Indirect Coombs' Test

Question 37

Damaged RBCs upon passing through obstructed or narrowed vessel lumina Cardiac valve prosthesis

Answer 37

Microangiopathic HA

Question 38

RBCs with spikes

Answer 38

Burr cells or echinocytes | Microangiopathic HA

Question 39

Fragmented RBCs | Halved RBCs

Answer 39

Schistocytes Helmet cells Microangiopathic HA

Question 40

Intrinsic hemolysis | Extravascular site

Answer 40

Hereditary spherocytosis Sickle cell anemia Thalassemia

Question 41

Intrinsic hemolysis | Both intra and extravascular

Answer 41

G6PD deficiency

Question 42

Intrinsic hemolysis | Intravascular site

Answer 42

PNH

Question 43

Extrinsic hemolysis | Intravascular site

Answer 43

Autoimmune HA Microangiopathic HA Macroangiopathic HA

Question 44

Anemias of diminished erythropoiesis

Answer 44

``` Megaloblastic Pernicious IDA Chronic disease Aplastic Pure red cell aplasia ```

Question 45

Macroovalocytes Hyper segmented neutrophils Giant metamyelocytes

Answer 45

Megaloblastic anemia

Question 46

Autoimmune gastritis resulting to failure of intrinsic factor production

Answer 46

Pernicious anemia

Question 47

Atrophy of fundic glands: chief and parietal Gastric mucosa replaced by goblet cells Beefy tongue Demyelination of dorsal and lateral tracts of spinal cord

Answer 47

Intestinalization Atrophic glossitis Pernicious anemia

Question 48

Schilling test

Answer 48

Pernicious anemia

Question 49

Schilling test | Stage 1 normal

Answer 49

B12 deficiency

Question 50

Schilling test Stage 1 low Stage 2 normal

Answer 50

Pernicious anemia

Question 51

Schilling test | Both stages are low

Answer 51

Malabsorption

Question 52

Iron absorbed primarily in the

Answer 52

Proximal duodenum

Question 53

Koilonychia spoon nails Pica Plummer Vinson syndrome

Answer 53

IDA

Question 54

Esophageal webs Microcytic hypochromic anemia Atrophic glossitis

Answer 54

Plummer Vinson syndrome

Question 55

IL6 stimulates inc in _ causing reduced iron transfer from storage pool to BM

Answer 55

Hepcidin

Question 56

Inc serum iron Low TIBC Inc ferritin Inc transferrin sat

Answer 56

Hemochromatosis | Thalassemia

Question 57

Low serum iron Low TIBC Inc ferritin

Answer 57

Chronic Disease

Question 58

Low serum iron Inc TIBC Low ferritin Low transferrin salt

Answer 58

IDA

Question 59

Idiosyncratic effect of this drug is aplastic anemia

Answer 59

Chloramphenicol

Question 60

Occupational chemical exposure causes aplastic anemia

Answer 60

Benzene

Question 61

Hypocellular BM with fat cells | Hypercellular BM with fat cells

Answer 61

Aplastic anemia | Polycythemia vera

Question 62

Anemia Thrombocytopenia Neutropenia Without splenomegaly

Answer 62

Aplastic anemia

Question 63

Non thrombocytopenic purpura due to increased fragility of cells

Answer 63

T

Question 64

PC<100,000

Answer 64

Thrombocytopenia

Question 65

Thrombocytopenia

Answer 65

Immune thrombocytopenic purpura | Thrombotic microangiopthies

Question 66

Most feared complication of immune thrombocytopenic purpura

Answer 66

Intracranial bleeding

Question 67

Thrombotic microangiopathies

Answer 67

Thrombotic thrombocytopenic purpura | HUS

Question 68

``` Renal failure Anemia Thrombocytopenia Fever Neurologic deficit ```

Answer 68

Thrombotic thrombocytopenic purpura

Question 69

Renal failure Anemia Thrombocytopenia

Answer 69

HUS

Question 70

Platelet dysfunction

Answer 70

Bernard Soulier | Glanzmann's thrombasthenia

Question 71

Inc bleeding time | Dec PC

Answer 71

Bernard Soulier

Question 72

Inc bleeding time | Normal PC

Answer 72

Glanzmann's thrombasthenia

Question 73

Coagulation disorders

Answer 73

Von Willebrand Hemophilia DIC

Question 74

Most common inherited bleeding disorder | Treatment

Answer 74

Von Willebrand | Desmopressin

Question 75

Most common hereditary disease with life threatening bleeding

Answer 75

Hemophilia A | Factor VIII

Question 76

Christmas disease

Answer 76

Hemophilia B | Factor IX deficiency

Question 77

Most specific test for DIC

Answer 77

D dimer

Question 78

Associated with obstetrics and trauma

Answer 78

Acute DIC

Question 79

Occurs in cancer patients | N PC and clotting factors

Answer 79

Chronic DIC