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Flashcards in Red Blood Cells And Bleeding Disorders Deck (80):
0

Average volume of a red cell expressed in femtoliters

Mean Cell Volume

1

Average content (mass) of hemoglobin per red cell expressed in picograms

Mean Cell Hemoglobin

2

Average concentration of hemoglobin in a given volume of packed red cells expressed in grams per deciliter

Mean Cell Hemoglobin Concentration

3

Coefficient of variation of red cell volume

Red Cell Distribution Width

4

Inc RDW
Dec RDW

Iron deficiency
Thalassemia

5

Hemolytic Anemias

Hereditary spherocytosis
G6PD deficiency
Sickle cell anemia
Thalassemia
Autoimmune HA
Microangiopathic HA
Macroangiopathic HA

6

Mutations of ankyrin, spectrin, band 3 and band 4.2

Hereditary spherocytosis

7

Hemolytic anemia
Aplastic crisis
Hemolytic crisis

Parvovirus B19
EBV mononucleosis

8

Small dark nuclear remnants present in RBCs of asplenic patients

Howell Jolly bodies
Hereditary spherocytosis

9

Symptoms of extravascular hemolysis

Anemia
Splenomegaly
Jaundice

10

Symptoms of intravascular hemolysis

Anemia
Hemoglobinemia
Hemoglobinuria
Hemosiderinuria
Jaundice

11

Episodic hemolysis

G6PD deficiency

12

Triggers of G6PD deficiency

INFECTIONS
Drugs antimalarials sulfonamides
Fava beans

13

Membrane bound precipitates on denatured globin chains

Heinz bodies
G6PD def

14

RBCs with damaged membranes removed by splenic macrophages

Bite cells

15

Recovery phase of G6PD deficiency heralded by

Reticulocytosis

16

6th codon of B globin: glu to val

Sickle cell anemia

17

RBCs shaped like curved blades

Sickled cells
Sickle cell anemia

Reticulocytosis
Howell Jolly bodies

18

Trapping of sickled red s leading to splenic infarction

Autosplenectomy
Sickle cell anemia

19

Types of crisis in Sickle cell anemia

Vasoocclusive
Sequestration
Aplastic

20

Chronic tissue hypoxia
Hyposthenuria - cannot concentrate urine
Infections
Prominent cheekbones
Crewcut skull appearace
Chronic hyperbilirubinemia

Sickle Cell Anemia

21

Sickle cell anemia
Initial dx test

Periph blood smear

22

Sickle cell anemia
Gold std

Hb electrophoresis

23

Sickle cell anemia
DOC

Hydroxyurea

24

Alpha thalassemia
1
2
3
4

Silent carrier state
A thalassemia trait
Hemoglobin H disease
Hydrops fetalis

25

Beta thalassemias
Transfusion dependence. HbF
Severe but no transfusion
Asx

Major cooley's anemia
Intermedia
Minor

26

Dehydrated RBCs with bull's eye appearance

Target cells or codocytes
Thalassemia

27

Basophilic stippling
Anisocytosis
Poikilocytosis
Microcytic hypochromic anemia

Thalassemia

28

Crew cut skull appearance
Chipmunk facies
Hemosiderosis
Hemochromatosis

Thalassemia

29

Treatment for hemochromatosis

Phlebotomy

30

DOC for hemochromatosis

Deferoxamine chelation

31

Leading cause of death in PNH

Thrombocytosis

32

Warm agglutinin
Cold agglutinin

IgG
IgM

33

Autoimmune HA seen in SLE, CLL or methyldopa

Warm agglutinin

34

Autoimmune HA seen in Mycoplasma and mononucleosis

Cold agglutinin

35

Anti Ig antibody added to patient's RBCs agglutinate if RBCs are coated with Ig

Direct Coombs' Test

36

Normal RBCs added to serum agglutinate if serum has Ig

Indirect Coombs' Test

37

Damaged RBCs upon passing through obstructed or narrowed vessel lumina
Cardiac valve prosthesis

Microangiopathic HA

38

RBCs with spikes

Burr cells or echinocytes
Microangiopathic HA

39

Fragmented RBCs
Halved RBCs

Schistocytes
Helmet cells
Microangiopathic HA

40

Intrinsic hemolysis
Extravascular site

Hereditary spherocytosis
Sickle cell anemia
Thalassemia

41

Intrinsic hemolysis
Both intra and extravascular

G6PD deficiency

42

Intrinsic hemolysis
Intravascular site

PNH

43

Extrinsic hemolysis
Intravascular site

Autoimmune HA
Microangiopathic HA
Macroangiopathic HA

44

Anemias of diminished erythropoiesis

Megaloblastic
Pernicious
IDA
Chronic disease
Aplastic
Pure red cell aplasia

45

Macroovalocytes
Hyper segmented neutrophils
Giant metamyelocytes

Megaloblastic anemia

46

Autoimmune gastritis resulting to failure of intrinsic factor production

Pernicious anemia

47

Atrophy of fundic glands: chief and parietal
Gastric mucosa replaced by goblet cells
Beefy tongue
Demyelination of dorsal and lateral tracts of spinal cord

Intestinalization
Atrophic glossitis

Pernicious anemia

48

Schilling test

Pernicious anemia

49

Schilling test
Stage 1 normal

B12 deficiency

50

Schilling test
Stage 1 low
Stage 2 normal

Pernicious anemia

51

Schilling test
Both stages are low

Malabsorption

52

Iron absorbed primarily in the

Proximal duodenum

53

Koilonychia spoon nails
Pica
Plummer Vinson syndrome

IDA

54

Esophageal webs
Microcytic hypochromic anemia
Atrophic glossitis

Plummer Vinson syndrome

55

IL6 stimulates inc in _ causing reduced iron transfer from storage pool to BM

Hepcidin

56

Inc serum iron
Low TIBC
Inc ferritin
Inc transferrin sat

Hemochromatosis
Thalassemia

57

Low serum iron
Low TIBC
Inc ferritin

Chronic Disease

58

Low serum iron
Inc TIBC
Low ferritin
Low transferrin salt

IDA

59

Idiosyncratic effect of this drug is aplastic anemia

Chloramphenicol

60

Occupational chemical exposure causes aplastic anemia

Benzene

61

Hypocellular BM with fat cells
Hypercellular BM with fat cells

Aplastic anemia
Polycythemia vera

62

Anemia
Thrombocytopenia
Neutropenia
Without splenomegaly

Aplastic anemia

63

Non thrombocytopenic purpura due to increased fragility of cells

T

64

PC<100,000

Thrombocytopenia

65

Thrombocytopenia

Immune thrombocytopenic purpura
Thrombotic microangiopthies

66

Most feared complication of immune thrombocytopenic purpura

Intracranial bleeding

67

Thrombotic microangiopathies

Thrombotic thrombocytopenic purpura
HUS

68

Renal failure
Anemia
Thrombocytopenia
Fever
Neurologic deficit

Thrombotic thrombocytopenic purpura

69

Renal failure
Anemia
Thrombocytopenia

HUS

70

Platelet dysfunction

Bernard Soulier
Glanzmann's thrombasthenia

71

Inc bleeding time
Dec PC

Bernard Soulier

72

Inc bleeding time
Normal PC

Glanzmann's thrombasthenia

73

Coagulation disorders

Von Willebrand
Hemophilia
DIC

74

Most common inherited bleeding disorder
Treatment

Von Willebrand
Desmopressin

75

Most common hereditary disease with life threatening bleeding

Hemophilia A
Factor VIII

76

Christmas disease

Hemophilia B
Factor IX deficiency

77

Most specific test for DIC

D dimer

78

Associated with obstetrics and trauma

Acute DIC

79

Occurs in cancer patients
N PC and clotting factors

Chronic DIC