Flashcards in Regal- Anti-inflammatory and Immunosuppressive Learning Exercises Deck (29)
What are the symptoms associated with hives?
Wheal and flare
Swelling (edema- increased vascular permeability)
What inflammatory mediators are associated w/ Redness?
Histamine (mast cells/basophils)
Which inflammatory mediators are associated with swelling?
Which inflammatory mediators are associated w/ pain?
What mediator is associated with the intrinsic pathway and what does it do?
FActor XII--> XIIa
Histamine stimulates what receptor?
R on smooth muscle cells/basophils/mast cells
H1, H1--are primary targets
What receptors do PGE and PGI stimulate?
What receptors do kinins stimulate?
B1 and B2
A 24 year old woman comes to your office w/ hives covering her arms and legs.
What hypersensitivity mechanism could explain her symptoms?
Allergy-type I hypesensitivity
Describe the pathological process of type I hypersensitivity?
Pollen crosslinks IgE>
Why might an anti-histamine be ineffective in treating her symptoms?
Anti-histamine will only effect histamine and not the other mediators/production of hives.
If a pt has already tried taking anti-histamines to treat hives, what would you prescribe next and why?
Diphenhydramine- only effects histamine
Steroids- broad anti-inflammatory effects
What is amalizumab?
Anti-IgE Ab--> has a broader effect than most drugs without compromising ability to combat infection
What drugs affect ACh?
What inflammatory mediators can cause bronchoconstriction?
How do increasing amts of Ach effect bronchoconstriction (dose response curve)?
As ACh increases, bronchoconstriction increases than plateaus
What is atropine?
What does atropine do the the DRC?
shifts curve right
What are the adverse effects of atropine?
What receptor do antihistamines effect?
What are the two older antihistamines and what do they do?
Shift curve right but less than atropine
What are the adverse effects of older antihistamines?
What distinguishes new antihistamines from old?
Anti-cholineric effects--> won't dry secretions
Don't get into CNS because they're pumped out by p-glycoprotein--> less sedation
What are the four examples of non-sedating anti-histamines?
What does fexonfenadine do to the DRC?
What drugs effect histamine?
What does atropine do to the DRC?
What is diphenhydramine?
competitive antagonist of H1 receptor