Diebel- Immunology Review Flashcards Preview

IHO Week 6 > Diebel- Immunology Review > Flashcards

Flashcards in Diebel- Immunology Review Deck (20)
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1

What are the primary lymphoid organs?

BM
Thymus

2

What happens in the primary lymphoid organs?

HSC differentiate into:

Lymphoid precursors>
DCs
B cell progenitors
Thymus> T cell precursors> CDR4 and CD8

Myeloid precursors>
granulocyte/monocyte pre
eosinophil pre
basophil pre
megakaryocyte pre
erythrocyte pre

3

What are secondary lymphoid organs?

spleen
LN
malt

4

What cells do you find in secondary lymphoid organs?

Mature B2 B cells

Th0--> Th1, Th2, Th17, T reg

CD8

5

What do you find in the periphery?

DC
NK
Monocytes
Neutrophils
Eosinophils
Basophils
Platelets
RBCs

6

What is the percentages of cells in the granulocyte series?

Monocytes 1-6%
Neutrophils 50-70 %
Eosinophils 1-3%
Basophils <1%

7

CD2 marker
(LFA-3 R)

Adhesion molecule that facilitates co-stimulation (synapse w/ T cell and APC)

Th
Tc
NK

8

CD3

TCR signaling

Th
Tc

9

CD4

Binds to MHC II

Th

10

CD5

?

B1-B cells
Th
Tc
NK

11

CD8

MCH I

Tc

12

CD16 is also known as.....

FcyRIII--causes Ab dependent cell mediated cytotoxicity (ITAM)

NK

13

CD19

Signal transduction, often works w/ CD21
B cells

14

CD21

(CR2)

Receptor for complement--binds CD3 fragment

Bcells

15

CD28

Binds B7 during activation (can't bind--> angergy)

Th
Tc

16

CD32

FcyRII

B cells


17

What are the two types of CD32 and what do they do?

a- phagocytoisis--> MCHII--> T cell help--> class switch recombination

b- blocks phagocytosis--> stimulation to become memory cells

18

CD35

Receptor for complement, C3b fragments (CR1 receptor)

B cells

19

CD40

Stim by CD4 T cells

B cells

20

CD40L

Th
Tc