Renal Transplantation Flashcards
(42 cards)
where is a kidney transplanted to
the iliac fossa
what blood vessels are the kidney typically anastomosed onto
iliac vessels
two reasons why you might remove the native kidneys
polycystic kidneys or infection
vascular complications of transplant surgery
bleeding from anastomotic sites
arterial or venous thrombosis
lymphocele (collection of lymphatic fluid where it shouldn’t be)
2 non-vascular complications of kidney transplant
urine leak and infections
first line of immunesuppression
basiliximab
is the kidney put in or out of the peritoneum
outside
long term maintenance immunesuppression
tacrolimus, mycophenolate and steroids
what drug type does mycophenolate belong to (azathioprine is also one)
anti-proliferative immunosuppressants
ciclosporin and tacrolimus are two examples of what kind of drug
immunosuppressants
4 major side effects of the immunosuppressants used
hyperglycaemia, AKI, hypertension, hirtuitism
what does ESRD stand for
end-stage renal disease
patients with what condition should all be considered for transplant
end-stage renal disease
proportion of donors that are dead
85-90%
what immune cells are induction immunesuppressants aimed at
T cells
two types of deceased donors
donation after brain death/cardiac death
3 types of living unrelated donors
spousal, altruistic and paired/pooled
principal of paired donation
two pairs where the donor matches the recipient of the other pair and vice versa
principal of pooled donation
living donors who don’t match their intended recipient but match another
long term, which has better survival rate, transplant or dialysis
transplant
two types of acute rejection
T cell mediated and acute antibody mediated
what is hyperacute rejection
rejection occuring within minutes of transplant, not so common
how does T cell mediated rejection present
fever, swollen kidney, rapidly increasing creatinine
histological signs of TCMR
lymphocytic infiltrate
