Flashcards in Reproductive Embryology Deck (32):
Which ridge of the intermediate mesoderm makes the genital system?
Gonadal or genital ridge
When is phenotypic sex made manifest?
Seventh week of development
What gene is important for male phenotype? What does it produce?
SRY (sex determining region of Y)
What is the most common abnormality of sexual differentiation?
What is the genotype of klinefelter syndrome?
Are people affected by Klinefelter male or female?
Male, with femininization
What are the symptoms of turner syndrome?
High arched palate
Cardiac and renal anomalies
What is the genotype of Turner syndrome?
What genotype do true hermaphrodites have?
Where do gametes come from in development?
Umbilical vesicle (yolk sac)
Where to gametes migrate to in development?
When does gamete migration happen? (what week)
What do developing gonads consist of?
Primordial germ cells
What serve as the precursors to the Sertoli cells?
What do the cortical cords form?
What do the mesonephric ductules become?
Efferent ductules, then distal epididymis
What forms the interstitial cells of Leydig?
_______ induces Sertoli cells to produce ________, which suppresses development of the ___________ ducts.
Anti-mullerian hormone (Mullerian inhibitor substance)
Paramesonephric (mullerian ducts)
What does the indifferent sexual duct system consist of?
Mesonephric ducts (Wolffian)
Paramesonephric ducts (Mullerian)
Where do the caudal ends of the paramesonephric ducts fuse?
What is the remnant of the paramesonephric duct called in males?
What stimulates the mesonephric duct to mature? What does it turn into?
Testosterone from interstitial cells
Epididymis, ductus deferens, ejaculatory duct
What stimulates the development of the seminal vesicles? Where does it bud out from?
What forms the prostate gland?
Epithelial outgrowth of pelvic urogenital sinus
What forms the bulbourethral gland?
Epithelial outgrowth of spongy urethra (UG sinus)
The absence of this allows paramesonephric duct development?
When the two paramesonephric ducts fuse, what forms?
What forms the upper one-third of the vagina?
What forms the lower two-thirds of the vagina?
What are the female homologues of the bulbourethral glands?
Greater vestibular glands
What causes mesonephric ducts to regress?
Lack of testosterone