Thyroid Gland Histology Flashcards Preview

HRM - Anatomy/Embryology/Histology > Thyroid Gland Histology > Flashcards

Flashcards in Thyroid Gland Histology Deck (15):
1

What is the embryological origin of the thyroid gland?

Endoderm downgrowth between pouches I and II

2

What are C-cells from?

Neural crest cells

3

What do C cells make?

Calcitonin

4

What do follicular cells synthesize?

Thyroid hormones

5

What activates follicular cells?

TSH

6

What do inactive follicular cells look like?

cuboidal/squamous
Few mitochondria, small golgi, some RER

7

What do activated follicular cells look like?

Columnar
Many mitochondria, enlarged golgi
Increased RER
Colloid absorbed
Apical lysosomes

8

C cells are also known as...

Parafollicular cells

9

What does calcitonin do?

LOWERS calcium in blood by inhibiting bone resorption
Decreases osteoclasts
Promoting clacium and phosphate excretion

10

What protein makes up colloid in the thyroid gland?

Thyroglobulin

11

What oxidizes iodide in the colloid?

Thyroid peroxidase

12

What gets iodinated in colloid?

Tyrosyl residues

13

What protein on the colloid surface transports iodide? Blood surface?

Colloid: Pendrin
Blood: Na/I symporter

14

How is thyroglobulin taken up?

Pinocytosis

15

Where is thyroglobulin proteolyzed?

In lysosomes