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Research/tests Flashcards

(5 cards)

1
Q

In a paired t-test, what p value shows a statistically significant difference between the samples?

A

p < 0.05 (5%)

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2
Q

In a paired t-test what does the p value represent?

A

The probability that the difference seen between the 2 groups has occurred by chance

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3
Q

Sensitivity vs specificity

A

Sensitivity - how well a test identifies those with the disease (true positive)

Specificity - how well a test identities those without the disease (true negative)

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4
Q

How to calculate sensitivity

How to calculate specificity

A

Sensitivity = true positive / (true positive + false negative)

Specificity = true negative / (true negative + false positive)

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5
Q

Whole genome seq vs karyotype vs FISH vs DNA methylation tests

A

WGS:
comprehensive, base-pair level analysis, especially undiagnosed rare diseases

Karyotyping:
suspected gross abnormality e.g. whole-chromosome/large structural such as trisomy/translocation

FISH:
targeting specific known genetic abnormality, more rapid

DNA methylation:
Prader-Willi/Angelman syndrome - abnormal methylation plays key role

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