Respiration Flashcards

(46 cards)

1
Q

Name some of the functions of the respiratory system

A

gas exchange, regulates: blood pH, angiotensin, vocalisation, Olfaction, blood pressure,

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2
Q

What are the upper and lower parts of the respiratory system

A

upper - nose to pharynx (shared with food)

Lower - larynx to lungs (air only)

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3
Q

Name the conducting zones of the respiratory system

A

nose, pharynx, larynx, trachea, bronchi, bronchioles, terminal bronchioles

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4
Q

Name the respiratory zones of the system

A

respiratory bronchioles, alveolar ducts, alveolar sacks, alveoli

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5
Q

Describe the structure and function of the respiratory epithelium

A

epithelial cells are pseudostratified ciliated coumner and have goblet cells, lines the wall of conducting zone

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6
Q

In the respiratory zone how does the epilthelium change

A

it becomes squamous (thinner) to allow better gas exchange

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7
Q

What is the function of the nasal conchae & meatus

A

Conchae - turbulate air, remove particles, increase time for contact with mucosa & olfactory receptors & heat air
Meatus - Increase surface area for contact with mucosa & heat air

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8
Q

What are the three anatomical regions of the pharynx

A

Nasopharynx
Oropharynx -
Laryngopharynx

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9
Q

what is the name of the cartilage which prevents food going down the throat, what seals of the nasal cavity from the nasopharynx

A

epiglottis, soft pallet

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10
Q

What is the function of Larynx

A

connects pharynx to trachea. Contains cartilage, thyroid cartilage (adams apple)

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11
Q

Describe the structure of the trachea

A

12cm long 2.5cm wide. Anterior to oesophagus. c-shaped cartilage hold it open. splits at the carina (contains lots of mechanoreceptors which trigger a powerful cough reflex

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12
Q

Describe the bronchial tree and which ones are help open with cartilage

A

Primary, Secondary, tertiary (last ones help open with cartilage), bronchioles, terminal bronchioles, respiratory bronchioles - alveoli

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13
Q

What are the two types of epithelial cells involved in gas exchange

A

All simple squamus epithelium,
type 1 - involved in gas exchange
type 2 - secrete surfactant - which helps to keep alveoli from collapsing, so reduces the surface tension on the walls of the alveoli

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14
Q

Describe the lungs and the membrane which surrounds it

A

take up most of the thoracic cavity surrounded by pleural membrane with both parietal and visceral layers. Pleural fluid prevents friction& causes layers to adhere to one another - surface tension

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15
Q

Describe the structures of the left and right lungs

A

Right- horizontal fissure
left fissure
everything enters and leaves through the hilum

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16
Q

what is the name of the nerve which supplies the diaphragm

A

Phrenic Nerve C 3,4,5

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17
Q

Why does ventilation increase during exercise

A

to maintain blood gas homeostasis

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18
Q

What is partial pressure

A

The sum of partial pressure of gas must add up to the total pressure. Partial pressure of a gas = Fraction of gas in gas * barometric pressure

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19
Q

What are the partial pressures of oxygen and CO2 in the alveolar and deoxygenated blood before gas exchange

A

Alveoli - PO2 = 102, PCO2 = 40 mmHg

capillary - PO2 = 40, PCO2 = 46 mmHg

20
Q

Name the muscles used for forced exhilation

A

internal intercostal muscles, external oblique, internal oblique, rectus abdominus (abdominal muscles)

21
Q

Describe the difference during active breathing

A

inhalation: greater contraction of the diaphragm, Inspiratory accessory muscles active
Expiration: Abdominal muscles, internal intercostal muscles

22
Q

Name the 5 pressures in the lungs

A
barometric pressure, elastic recoil pressure, 
Pleural pressure (interpleural cavity (between visearal & parietal pleura) always negative & stops the lungs from collapsing), alveolar pressure, transpulmonary pressure (pressure across lung) alveolar - pleural
23
Q

How i air filtered

A

airways are lined with psuedo-stratified, ciliated, columnar epithelium

24
Q

What is the volume of the alveolar capillary network at rest and during exercise & what is the distance between the alveoli and red blood cell

A

75 mls - rest
150 - 200 mls - during exercise
1 - 2 um

25
what 4 anatomical and physiological properties do the respiratory and circulatory systems have which facilitate gas diffusion
Large surface area large partiel pressure gradients gases with advantageous diffusion properties Specialised mechanisms for transporting O2 & CO2 between lungs & tissues
26
What are the two forms that oxygen is carried in the blood in
Dissolved | Haemoglobin (Hb)
27
What 3 forms is CO2 carried in the blood
7% dissolved 23% bound to haemoglobin 70% converted to bicarbonate
28
What are the 4 main aspects required to have control over breathing
Establish automatic rhythm (subconscious) Respond to metabolic demands respond to mechanical changes (posture) Range of episodic non ventilatory behaviours (speaking, sniffing, eating)
29
What is the bodies response to low PO2 (Hypoxia)
there is little effect until PO2 < 60mmHg Chemoreceptors in the carotid detect the change and increase ventilation
30
What is the respiration response to increased PCO2 (hypercapnia)
Small changes of PCO2 have large affects on Ventilation (unlike PO2). Response starts from the central chemoreceptors in the brainstem, ventilation increases until normal PCO2 is restored
31
What do the Mechanoreceptors detect changes in
pressure, movement & touch
32
Through which nerve are signals from sensors in the lung sent
Vagus nerve
33
What is the dorsal respiratory group responsible for regulating
located in the (NTS) receives sensory information
34
What is the Ventral respiratory group responsible for
Both inspiratory & expiratory neurons, | Contains motor neurons & rhythm generating neurons
35
What is the Pontine respiratory group responsible for
Modulates respiratory output
36
The brainstem neurons produce rhythmic output & send them to the spinal chord. Through which nerve is the signal sent from the muscle & at what point from the spinal chord
Phrenic nerve exits the spinal chord at level 3-5 & innervates the diaphragm. Nerves which innervate the intercostal muscles exit the thoracic spinal chord
37
What is the treatment for an anaphylactic reaction
Adrenaline
38
What are the three efferent (too the lungs) pathways of respiration responses to conditions
Parasympathetic - Bronchoconstriction & mucus secretion Sympathetic - releases adrenaline which dilates the airways Inhibitory non-noradrenergic non-cholinergic (NANC) - nerves relax the smooth muscle in the airways
39
What is Asthma & what is it typically treated with
reversible obstructive lung disease, chronic inflammatory condition with acute exacerbations treated with inhaled steroids
40
What is Asthma
smooth muscle hypertrophy & contraction, Oedema (rise of capillary pressure & fluid transfer into the tissue), Mucus hyper-secretion, Epithelial damage, Infiltration of inflammatory cells, Bronchial hyper reactivity
41
What are the two phases of asthma reaction
Early phase - Bronchospasm (received from inhaled steroid) | Late Phase - inflammation (inhaled bronchodilator)
42
What do B2 agonists do?
Activates the B2 receptor, relaxing the bronchioles e.g. Salbutamol & terbutaline. Drugs with longer chains e.g. salmeterol will last longer
43
What does a Muscarinic antagonist do?
Reduces mucus secretion ipratropium, can be put in a nebuliser (for extreme asthma)
44
What do Methylxanthines
Inhibits PDE increases airway diameter
45
How to glucocorticoids work?
Inhibit prostanoids, leukotrienes & cytokines, e.g. reduce the generation of pro-inflammatory mediators by preventing the production of Phospholipase A2 at the nucleus
46
Why should asthma patients not take ibuprofen
Prevents the production of cycloxyginase which pushes the pathway to produce leukotrienes