Respiratory Drugs Flashcards
what causes bronchoconstriction in asthma?
histamine
prostaglandins
leukotrienes
what is the most common cause of all allergies that lead to an asthma exacerbation?
house dust mites
which receptor should be worked with to promote bronchodilation?
beta 2
what does stimulation of beta 2 receptors cause?
increased cAMP
inhibits smooth muscle contraction
why should beta blockers be avoided in patients with asthma and COPD?
cause bronchoconstriction
asthma is caused by what type of agent?
sensitizing
COPD is caused by what type of agent?
noxious
what is preferred over sq epinephrine for continuous nebulizing therapy for status asthmaticus (asthma exacerbation)?
low-dose B2 agonist
how does tolerance occur in LABAs?
down-regulation of B2 receptors
what 2 medications exacerbate bronchospasms?
NSAIDs
Aspirin
what occurs to the body when corticosteroids are stopped cold turkey?
body goes into adrenal crisis
what effect do long-term corticosteroids have on adrenal function?
suppress adrenal function since we are receiving exogenously
which corticosteroid is the slow acting one?
hydrocortisone
what medication can be used to activate ICS in the lungs, rather than the mouth, to avoid thrush?
ciclesonide
why are ICS good for children?
high first pass effect = does not suppress growth
(we lose a lot of it in the other systems)
